Case Report | Published:

Acute disseminated encephalomyelitis (ADEM) after autologous peripheral blood stem cell transplant for non-Hodgkin’s lymphoma

Bone Marrow Transplantation volume 24, pages 13511354 (1999) | Download Citation

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Abstract

Acute disseminated encephalomyelitis (ADEM) is a demyelinating disorder of the central nervous system with an acute clinical onset and a wide variability in severity and outcome. It usually follows a viral infection or an immunization and is thought to be immuno- mediated. We report a case of ADEM with a dramatic clinical onset in an autologous peripheral blood stem cell transplant (PBSCT) recipient for non-Hodgkin’s lymphoma who developed the neurologic syndrome 12 days after PBSC reinfusion. This is the first report of ADEM in the setting of autologous PBSCT, a therapeutic procedure performed with increasing frequency in a wide variety of hematologic and solid malignancies.

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Affiliations

  1. Department of Hematology, University of Parma, Italy

    • A Re
    •  & R Giachetti

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Correspondence to R Giachetti.

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DOI

https://doi.org/10.1038/sj.bmt.1702047