Abstract
Bone turnover markers and bone mineral density (BMD) were studied in 25 adult patients (14 females, 11 males) who had undergone allogeneic bone marrow transplantation (BMT). The interval from BMT to the first examination was at least 1 year (mean 3, range 1–10). Mean age of the patients at the time of first evaluation was 42 (range 19–54) years. Blood samples and urine collections for evaluation of biochemical factors reflecting skeletal turnover were performed together with the first BMD measurement. BMD was measured from the lumbar vertebrae (L2 to L4) with computed tomography and results were expressed as Z-scores. At the time of the first measurement five patients (20%) had Z-scores <−2.5 s.d. and 12 patients (48%) between −1 and −2.5 s.d. in 12 patients bmd assessments were repeated and it seemed that reduction in bmd had mostly occurred during and shortly after bmt and remained the same during follow-up. the cross-linked carboxyterminal telopeptide of type i collagen (ictp) correlated negatively with bmd (r = −0.45, P = 0.045) as did bone-specific alkaline phosphatase (BAP; r = −0.64, P = 0.002). No correlation between BMD and time interval from diagnosis to BMT, conditioning regimen, corticosteroid use or hospital stay during transplantation was found. In conclusion, bone disease is common after BMT. Our findings demonstrate an increased collagen and bone turnover and a high risk of osteoporosis. BMD measurements must be repeated regularly and collagen markers such as ICTP and BAP can be beneficial in estimating the activity of bone disease.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kauppila, M., Irjala, K., Koskinen, P. et al. Bone mineral density after allogeneic bone marrow transplantation. Bone Marrow Transplant 24, 885–889 (1999). https://doi.org/10.1038/sj.bmt.1701989
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.bmt.1701989
Keywords
This article is cited by
-
High prevalence of early-onset osteopenia/osteoporosis after allogeneic stem cell transplantation and improvement after bisphosphonate therapy
Bone Marrow Transplantation (2008)
-
Beneficial treatment with risedronate in long-term survivors after allogeneic stem cell transplantation for hematological malignancies
Osteoporosis International (2003)
-
Renal function following hematological stem cell transplantation in childhood
Pediatric Nephrology (2003)