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Successful treatment of refractory acquired pure red cell aplasia (PRCA) by allogeneic bone marrow transplantation

Bone Marrow Transplantation volume 23, pages 1205–1207 (1999)Cite this article

Abstract

This case describes a 16-year-old woman treated successfully by a bone marrow transplant from her HLA-identical brother for refractory acquired pure red cell aplasia. Conditioning was as for severe aplastic anaemia with cyclophosphamide 4 × 50 mg/kg and antithymocyte globulin. Complete donor type engraftment at 3 months reversed to full autologous reconstitution at 2 years with normal haemopoiesis. The potential implications on pathogenesis of the disease as well as on treatment of autoimmune disorders by stem cell transplantation are discussed.

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Authors and Affiliations

  1. Division of Haematology, Department of Medicine, Kantonsspital, University of Basel, Switzerland

    BU Müller, JR Passweg & A Gratwohl

  2. Division of Haematology, Haematology Laboratory, Kantonsspital, University of Basel, Switzerland

    A Tichelli

  3. Division of Haematology, Department of Research, Kantonsspital, University of Basel, Switzerland

    C Nissen & A Wodnar-Filipowicz

Authors
  1. BU Müller
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  2. A Tichelli
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  3. JR Passweg
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  4. C Nissen
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  5. A Wodnar-Filipowicz
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  6. A Gratwohl
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Müller, B., Tichelli, A., Passweg, J. et al. Successful treatment of refractory acquired pure red cell aplasia (PRCA) by allogeneic bone marrow transplantation. Bone Marrow Transplant 23, 1205–1207 (1999). https://doi.org/10.1038/sj.bmt.1701785

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  • DOI: https://doi.org/10.1038/sj.bmt.1701785

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