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Rapid reversal of nephrotic syndrome due to primary systemic AL amyloidosis after VAD and subsequent high-dose chemotherapy with autologous stem cell support

Bone Marrow Transplantation volume 23, pages 967–969 (1999)Cite this article

Abstract

In a patient with nephrotic syndrome, renal biopsy revealed AL amyloid deposits. Monoclonal λ light chains were identified in serum and urine. A low percentage of monoclonal plasma cells was detected in the bone marrow. The patient received four cycles of VAD and subsequent high-dose chemotherapy (HDCT) with melphalan (200 mg/m2) followed by autologous peripheral blood stem cell transplantation. Proteinuria rapidly diminished during chemotherapy. Three months after HDCT, the patient has no edema, and no signs of plasma cell dyscrasia are currently detectable. Using VAD before starting HDCT may improve the condition of patients with amyloidosis and reduce transplantation-related morbidity and mortality.

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Authors and Affiliations

  1. Department of Internal Medicine, Universitätsklinikum Charité, Haematology/Oncology, Berlin, Germany

    O Sezer, P Schmid, M Schweigert, U Heider, J Eucker, H Harder & K Possinger

  2. Universitätsklinikum Charité, Institute of Clinical Chemistry and Biochemistry, Berlin, Germany

    P Sinha

  3. Universitätsklinikum Charité, Institute of Transfusion Medicine, Humboldt University, Berlin, Germany

    H Radtke

Authors
  1. O Sezer
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  2. P Schmid
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  3. M Schweigert
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  4. U Heider
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  5. J Eucker
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  6. H Harder
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  7. P Sinha
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  8. H Radtke
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  9. K Possinger
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Sezer, O., Schmid, P., Schweigert, M. et al. Rapid reversal of nephrotic syndrome due to primary systemic AL amyloidosis after VAD and subsequent high-dose chemotherapy with autologous stem cell support. Bone Marrow Transplant 23, 967–969 (1999). https://doi.org/10.1038/sj.bmt.1701765

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  • DOI: https://doi.org/10.1038/sj.bmt.1701765

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