Abstract
Lupus anticoagulant antibodies have never been reported to disappear after either allogeneic or autologous bone marrow transplantation in humans. We report the first case of disappearance of lupus anticoagulant antibodies in a patient without systemic lupus erythematosus or clinical evidence of other autoimmune disorders, who received an allogeneic bone marrow transplant as treatment for chronic myeloid leukemia. Although marrow transplantation is not a recognized therapy for antiphospholipid syndrome, our observation should be considered another example of the capability of intensive chemo-radiotherapy followed by stem cell transplantation to ablate a pathologic marrow clone resulting in an autoimmune disorder and improve, or even cure, some severe autoimmune diseases.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Olalla, J., Ortín, M., Hermida, G. et al. Disappearance of lupus anticoagulant after allogeneic bone marrow transplantation. Bone Marrow Transplant 23, 83–85 (1999). https://doi.org/10.1038/sj.bmt.1701516
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.bmt.1701516
Keywords
This article is cited by
-
Successful treatment of a case of catastrophic antiphospholipid syndrome with autologous BMT: case report and review of literature
Bone Marrow Transplantation (2011)
-
Ovarian tissue cryopreservation: benefits and risks
Cell and Tissue Research (2005)
-
Autologous hematopoietic stem cell transplantation for refractory antiphospholipid syndrome causing myocardial necrosis
Bone Marrow Transplantation (2004)
-
Acute graft-versus-host disease (aGVHD) presenting with an acquired lupus anticoagulant
Bone Marrow Transplantation (2003)
-
Induction of tolerance in autoimmune diseases by hematopoietic stem cell transplantation: Getting closer to a cure?
International Journal of Hematology (2002)