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Total body irradiation and cyclophosphamide is a conditioning regimen for unrelated bone marrow transplantation in a patient with chronic myelogenous leukemia and renal failure on hemodialysis

Bone Marrow Transplantation volume 22, pages 591–593 (1998)Cite this article

Abstract

Five years after the diagnosis of Ph chromosome-positive chronic myeloid leukemia (CML) a 31-year-old patient developed malignant nephrosclerosis with renal failure. He then underwent an allogeneic unrelated BMT in first chronic phase CML. The preparative regimen consisted of fractionated total body irradiation (TBI) and cyclophosphamide (CY). We studied the pharmacokinetics of cyclophosphamide on hemodialysis and compared clinical parameters including time to engraftment and toxicity with parameters of a patient with normal renal function who also received an unrelated marrow as treatment for CML in first chronic phase. Our results suggest that TBI/CY is a suitable conditioning regimen for allogeneic transplantation in patients with hematological malignancy and renal failure on hemodialysis.

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Authors and Affiliations

  1. Department of Hematology/Oncology and Bone Marrow Transplantation, Idar-Oberstein, Germany

    ME Bischoff, W Blau, N Basara & AA Fauser

  2. Division of Hematology/Oncology, Department of Internal Medicine, University of Lübeck, Germany

    T Wagner

  3. Department of Radiology, Hospital Idar-Oberstein, School of Medicine of the University of Mainz, Germany

    W Wagenmann

  4. Department of Internal Medicine, Hospital Idar-Oberstein, School of Medicine of the University of Mainz, Germany

    O Dörner

Authors
  1. ME Bischoff
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  2. W Blau
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  3. T Wagner
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  4. W Wagenmann
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  5. O Dörner
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  6. N Basara
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  7. AA Fauser
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Bischoff, M., Blau, W., Wagner, T. et al. Total body irradiation and cyclophosphamide is a conditioning regimen for unrelated bone marrow transplantation in a patient with chronic myelogenous leukemia and renal failure on hemodialysis. Bone Marrow Transplant 22, 591–593 (1998). https://doi.org/10.1038/sj.bmt.1701380

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  • DOI: https://doi.org/10.1038/sj.bmt.1701380

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