Case Report | Published:

Benefit of aggressive multimodality therapy with autologous stem cell support for intra-abdominal desmoplastic small round cell tumor

Bone Marrow Transplantation volume 21, pages 961963 (1998) | Download Citation

Subjects

Abstract

A case is described of a 19-year-old man with poor prognosis intra-abdominal desmoplastic small round cell tumor, who achieved a durable complete remission after aggressive multimodality treatment. He was diagnosed with a large peri-rectal mass and bulky metastases to the peritoneum, omentum and liver. He achieved a partial response to six courses of chemotherapy with VAC (vincristine, adriamycin, actinomycin, cyclophos- phamide) and VIP (VP-16, ifosfamide, cisplatin). This was followed by resection of the omentum and cryotherapy to six of the liver lesions. He then achieved a complete response following high-dose busulfan 16 mg/kg and melphalan 140 mg/m2 with autologous stem cell support. Finally, pelvic radiotherapy was given to consolidate the remission. Twenty-six months following his diagnosis, and 19 months after the transplant, he remains well with no clinical or radiologic evidence of recurrent disease. This case report suggests a role for autologous stem cell transplantation as part of multimodality therapy for this unusual and aggressive malignancy.

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Affiliations

  1. Medical Oncology, Tom Baker Cancer Centre and University of Calgary, Calgary, Alberta, Canada

    • M Mazuryk
    •  & DA Stewart
  2. Surgical Oncology, Tom Baker Cancer Centre and University of Calgary, Calgary, Alberta, Canada

    • AHG Paterson
    •  & W Temple
  3. Radiation Oncology, Tom Baker Cancer Centre and University of Calgary, Calgary, Alberta, Canada

    • K Arthur
  4. Pathology, Tom Baker Cancer Centre and University of Calgary, Calgary, Alberta, Canada

    • T Crabtree

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DOI

https://doi.org/10.1038/sj.bmt.1701220

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