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Successful treatment of pure red cell aplasia after major ABO-incompatible T cell-depleted bone marrow transplantation with erythropoietin

Bone Marrow Transplantation volume 20, pages 1105–1107 (1997)Cite this article

Abstract

A 40-year-old woman with acute myeloid leukemia in first remission developed pure red cell aplasia after a T cell-depleted ABO-incompatible bone marrow transplant from her HLA-identical sister. She remained transfusion-dependent for 11 months despite conversion of the ABO blood group to donor type, and titers of anti-donor isohemagglutinin being undetectable. Treatment with erythropoietin resulted in rapid improvement of the anemia with no further need for transfusions up to 21 months post-transplant. This case suggests that erythropoietin may provide effective therapy for pure red cell aplasia after ABO-incompatible bone marrow transplantation without the additional risks of further immunosuppression.

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Authors and Affiliations

  1. Unitat d’Hematologia Clínica, Departament d’Hematologia, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain

    A Santamaría, A Sureda, R Martino, A Domingo-Albós, E Muñiz-Díaz & S Brunet

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  1. A Santamaría
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  2. A Sureda
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  3. R Martino
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  4. A Domingo-Albós
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  5. E Muñiz-Díaz
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  6. S Brunet
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Santamaría, A., Sureda, A., Martino, R. et al. Successful treatment of pure red cell aplasia after major ABO-incompatible T cell-depleted bone marrow transplantation with erythropoietin. Bone Marrow Transplant 20, 1105–1107 (1997). https://doi.org/10.1038/sj.bmt.1701012

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  • DOI: https://doi.org/10.1038/sj.bmt.1701012

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