Abstract
The hepatitis C virus (HCV) infection has, in general, been considered not to affect liver function severely during the course of bone marrow transplantation (BMT) except for late hepatitis which coincided with a decrease in immunosuppressive therapy. We examined serial sera of two patients with positive HCV antibody who underwent allogeneic BMT and found that while the dose of cyclosporin A tapered off, the serum concentration of HCV core protein increased before the occurrence of hepatitis. This suggests that viral reactivation and growth might be one of the important mechanisms of hepatitis after BMT in patients with positive HCV antibody.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Author information
Authors and Affiliations
Consortia
Rights and permissions
About this article
Cite this article
Akiyama, H., Yoshinaga, H., Tanaka, T. et al. Effects of cyclosporin A on hepatitis C virus infection in bone marrow transplant patients. Bone Marrow Transplant 20, 993–995 (1997). https://doi.org/10.1038/sj.bmt.1700996
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/sj.bmt.1700996
Keywords
This article is cited by
-
Reactivation of hepatitis B virus and hepatitis C virus in patients with cancer
Nature Reviews Clinical Oncology (2012)
-
HCV cache: the list
Science-Business eXchange (2010)
-
Anforderungen an die Hygiene bei der medizinischen Versorgung von immunsupprimierten Patienten
Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz (2010)
-
Hepatitis C virus in long-term bone marrow transplant survivors
Bone Marrow Transplantation (2004)
-
Hepatitis C in the setting of kidney, heart, lung, and bone marrow transplants
Current Hepatitis Reports (2003)