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Blood bank leukocyte infusions as remission induction therapy in a case of acute lymphoblastic leukemia

Bone Marrow Transplantation volume 20, pages 707–708 (1997)Cite this article

Abstract

A 15-year-old female with pre-pre B ALL in third relapse was treated with administration of eight blood bank leukocyte concentrates per day for 5 days. The total number of mononuclear cells per kilogram of weight was 4.89 × 108. On the fifth day of infusions the patient was in complete remission (CR), asymptomatic and with a normal CBC. No secondary effects were found. The patient remained in CR without treatment for 10 weeks before relapsing again. The possibility of reaching a short-lived, clinically relevant response, using blood bank leukocyte infusions, is a promising new approach for the treatment of leukemia.

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Authors and Affiliations

  1. Hematology Department, Centro Médico Nacional ‘20 de Noviembre’, ISSSTE, Mexico City, Mexico

    JR Borbolla, MA López, M Alvarado, L Guzman, J DeDiego, E Trueba, M González & I Anaya

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  1. JR Borbolla
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  2. MA López
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  3. M Alvarado
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  4. L Guzman
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  5. J DeDiego
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  6. E Trueba
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  7. M González
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  8. I Anaya
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Borbolla, J., López, M., Alvarado, M. et al. Blood bank leukocyte infusions as remission induction therapy in a case of acute lymphoblastic leukemia. Bone Marrow Transplant 20, 707–708 (1997). https://doi.org/10.1038/sj.bmt.1700953

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  • DOI: https://doi.org/10.1038/sj.bmt.1700953

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