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Involvement of TNF-alpha secreting macrophages in lethal forms of human graft-versus-host disease

Bone Marrow Transplantation volume 20, pages 511–515 (1997)Cite this article

Abstract

We report three patients with lethal forms of acute GVHD in whom all biopsy specimens showed a striking preponderance of macrophages in the inflammatory infiltrate with production of TNF-alpha. The role of the macrophage/TNF-alpha axis in human acute GVHD is examined and the existence of primary macrophagic forms of GVHD is discussed.

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Authors and Affiliations

  1. Unité Régionale de Greffe de Moelle Osseuse, Service des Maladies du Sang, CHRU Lille, France

    T Facon, JP Jouet, MP Noel-Walter & F Bauters

  2. Service d’Anatomie Pathologique C, Hôpital Calmette, CHRU, Lille, France

    F Bloget & A Janin

Authors
  1. T Facon
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  2. JP Jouet
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  3. MP Noel-Walter
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  4. F Bloget
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  5. F Bauters
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  6. A Janin
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Facon, T., Jouet, J., Noel-Walter, M. et al. Involvement of TNF-alpha secreting macrophages in lethal forms of human graft-versus-host disease. Bone Marrow Transplant 20, 511–515 (1997). https://doi.org/10.1038/sj.bmt.1700912

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  • DOI: https://doi.org/10.1038/sj.bmt.1700912

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