Abstract
One of the possible drawbacks to autologous stem cell transplantation in breast cancer (BC) patients is the potential for tumor contamination in the transplanted product. We present a patient with advanced disease who received high-dose chemotherapy (HDC) and PBPC support as consolidation therapy after achieving complete remission with standard-dose first-line treatment, and suffered recurrence of the disease 6 months after transplantation. Retrospective analysis revealed the presence of contaminating cells in the leukapheretic product, and clinical evidence suggested a role for these cells in the tumor relapse.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Pedrazzoli, P., Battaglia, M., Prada, G. et al. Role of tumor cells contaminating the graft in breast cancer recurrence after high-dose chemotherapy. Bone Marrow Transplant 20, 167–169 (1997). https://doi.org/10.1038/sj.bmt.1700854
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/sj.bmt.1700854
Keywords
This article is cited by
-
Detection of breast cancer cell contamination in leukapheresis product by real-time quantitative polymerase chain reaction
Bone Marrow Transplantation (2001)
