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Transfer of autoimmune thyroiditis and resolution of palmoplantar pustular psoriasis following allogeneic bone marrow transplantation

Bone Marrow Transplantation volume 19, pages 1041–1043 (1997)Cite this article

Abstract

We report an unusual case of a patient who was cured of one autoimmune disease (palmoplantar pustular psoriasis (PPP)) but developed another autoimmune disease (autoimmune thyroiditis) after allogeneic BMT. A 40-year-old man suffering from AML with PPP underwent allogeneic BMT from his HLA-identical sister for the treatment of AML. The patient experienced complete clearance of the cutaneous PPP despite the cessation of immunosuppressive therapy for over 2 years. However, he developed hyperthyroidism with anti-thyroglobulin antibodies 5 months after BMT, although he had showed normal thyroid functions without anti-thyroglobulin antibodies before BMT. The donor had no history of thyroid diseases and showed normal thyroid functions but was positive for anti-thyroglobulin antibodies. Thus, even when the donor is in a subclinical state, autoimmune thyroiditis may be transferred from donors to recipients by BMT.

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Authors and Affiliations

  1. First Department of Internal Medicine, Kansai Medical University, Moriguchi, Osaka, Japan

    Y Kishimoto, Y Yamamoto, T Ito, N Matsumoto, H Ichiyoshi, T Katsurada, M Date, S Ohga, H Kitajima & S Fukuhara

  2. First Department of Pathology, Kansai Medical University, Moriguchi, Osaka, Japan

    S Ikehara

Authors
  1. Y Kishimoto
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  2. Y Yamamoto
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  3. T Ito
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  4. N Matsumoto
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  5. H Ichiyoshi
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  6. T Katsurada
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  7. M Date
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  8. S Ohga
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  9. H Kitajima
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  10. S Ikehara
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  11. S Fukuhara
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Kishimoto, Y., Yamamoto, Y., Ito, T. et al. Transfer of autoimmune thyroiditis and resolution of palmoplantar pustular psoriasis following allogeneic bone marrow transplantation. Bone Marrow Transplant 19, 1041–1043 (1997). https://doi.org/10.1038/sj.bmt.1700789

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  • DOI: https://doi.org/10.1038/sj.bmt.1700789

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