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Successful bone marrow transplantation from an HLA-identical unrelated donor in a patient with hemophagocytic lymphohistiocytosis

Bone Marrow Transplantation volume 19, pages 183–185 (1997)Cite this article

Abstract

We report a 3-year-old girl with hemophagocytic lymphohistiocytosis (HLH) who received BMT from an HLA-identical unrelated donor when the disease was active. She had entered remission in response to chemotherapy consisting of etoposide and methylprednisolone. After a relapse, her disease became refractory to chemotherapy, and splenectomy was performed with marginal improvement. She underwent BMT from an HLA-identical unrelated donor, conditioned with CY, TBI and anti-thymocyte globulin (ATG). She has been in complete remission for 18 months since the BMT. This result suggests that BMT from an HLA-identical unrelated donor should be considered for HLH even if the disease is active.

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Authors and Affiliations

  1. Department of Pediatrics, Kyoto University, Kyoto, Japan

    S Adachi, M Kubota, Y Akiyama, T Kato & K Furusho

  2. Department of Pediatrics, Maizuru Municipal Hospital, Maizuru, Japan

    T Kitoh

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  1. S Adachi
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  2. M Kubota
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  3. Y Akiyama
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  4. T Kato
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  5. T Kitoh
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  6. K Furusho
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Adachi, S., Kubota, M., Akiyama, Y. et al. Successful bone marrow transplantation from an HLA-identical unrelated donor in a patient with hemophagocytic lymphohistiocytosis. Bone Marrow Transplant 19, 183–185 (1997). https://doi.org/10.1038/sj.bmt.1700622

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  • DOI: https://doi.org/10.1038/sj.bmt.1700622

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