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Combination of Nitrogen-15-labelled Nitrogen Mustard with Proteins

Nature volume 168, pages 251–252 (1951)Cite this article

Abstract

THE nitrogen mustards readily inactivate certain enzymes1 and they also react with many other proteins2, including the components of hæmolytic complement3. Although it has been established by various investigators that the amino, sulphydryl, sulphide, carboxyl and pyridine groups of proteins are affected by the action of the nitrogen mustards4, there appears to be no precise quantitative information about the combination of the mustard with proteins.

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References

  1. Thompson, R. H. S., J. Physiol., 105, 370 (1946–47). Dixon, M., and Needham, D. M., Nature, 158, 432 (1946). Barron, E. S. G., Bartlett, G. R., and Miller, Z. B., J. Exp. Med., 87, 489 (1948). Cf. also reviews in ref. 2.

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  2. For the references see the reviews by Philips, F. S., Pharmacol. Rev., 2, 281 (1950). Karnofsky, D. A., “Nitrogen Mustards in the Treatment of Neoplastic Disease”, a chapter in “Advances in Internal Medicine” (The Year Book Publishers, Chicago, 4, 1950).

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  3. Watkins, W. M., and Wormall, A., Nature, 162, 535 (1948).

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  4. Cf., for example, Fruton, J. S., Stein, W. H., and Bergmann, M., J. Org. Chem., 11, 559 (1946). Fruton, J. S., Stein, W. H., Stahmann, M. A., and Golumbic, C., J. Org. Chem., 11, 571 (1946). Reviews in ref. 2.

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  5. Watkins, W. M., and Wormall, A. (in the press).

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Authors and Affiliations

  1. Department of Biochemistry, Medical College of St. Bartholomew's Hospital, London, E.C.1

    V. C. E. BURNOP, D. E. RICHARDS, W. M. WATKINS & A. WORMALL

Authors
  1. V. C. E. BURNOP
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  2. D. E. RICHARDS
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  3. W. M. WATKINS
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  4. A. WORMALL
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BURNOP, V., RICHARDS, D., WATKINS, W. et al. Combination of Nitrogen-15-labelled Nitrogen Mustard with Proteins. Nature 168, 251–252 (1951). https://doi.org/10.1038/168251b0

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  • DOI: https://doi.org/10.1038/168251b0

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