Abstract
IT seems to be generally accepted that, in addition to its antidiuretic effect, posterior pituitary extract has a chloruretic action. All workers appear to have found an increase of chloride concentration in the urine; but there is by no means unanimity whether the actual amounts excreted are increased, results varying with the species and experimental conditions (see, for example, Shannon1 and O'Connor2). Furthermore, it is not clear which of the posterior pituitary fractions is mainly responsible for the chloruretic effect, and whichions are excreted with the chloride.
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References
Shannon, J. A., J. Exp. Med., 76, 371 (1942).
O'Connor, W. J., Proc. Physiol. Soc., July 1–2 (1949).
Schaumann, O., and Schmidt, L., Arch. Exp. Path. u. Pharmakol., 205, 367 (1948).
Schaumann, O., Experientia (in the press).
Dicker, S. E., and Heller, H., J. Physiol., 104, 353 (1946).
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HELLER, H., STEPHENSON, R. Effect of Posterior Pituitary Extract and its Fractions on Renal Electrolyte Excretion. Nature 165, 189 (1950). https://doi.org/10.1038/165189a0
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DOI: https://doi.org/10.1038/165189a0
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