Abstract
HEIDELBERGER and his colleagues1 have made extensive quantitative studies of serological reactions using micro-methods for the determination of total nitrogen in specific precipitates, supplemented by the determination of the amount of dye present when dye-azoproteins were used as antigens. Other investigators have used antigens containing iodine2, copper3 and iron4 to enable the amount of antigen to be determined in precipitates obtained from a wide range of mixtures of antigen and antibody.
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References
Heidelberger, M., Bact. Rev., 3, 49 (1939). Heidelberger, M., “Immuno-chemistry”. Chapter 29 in “Currents in Biochemical Research” (Interscience Pub., Inc., 1946). Kabat, E. A., and Mayer, M. M., “Experimental Immunochemistry” (C. C. Thomas, 1948).
Wu, H., Sah, P. P. T., and Li, C. P., Proc. Soc. Exp. Biol., N.Y., 28, 737 (1929); cf. also the use of antigens containing both iodine and arsenic (Haurowitz, F., and Schwerin, P., J. Immunol., 47, 111 (1943)).
Hooker, S. B., and Boyd, W. C., J. Immunol., 30, 33 (1936).
Wu, H., Cheng, L. H., and Li, C. P., Proc. Soc. Exp. Biol., N.Y., 25, 853 (1929).
Boursnell, J. C., Dewey, H. M., Francis, G. E., and Wormall, A., Nature, 160, 339 (1947).
Francis, G. E., and Wormall, A., Biochem. J., 42, 469 (1948).
Banks, T. E., Boursnell, J. C., Dewey, H. M., Francis, G. E., Tupper, R., and Wormall, A., Biochem. J., 43, 518 (1948).
Landsteiner, K., “The Specificity of Serological Reactions” (Harvard Univ. Press; revised edit., 1945).
Boyd, W. C., “Fundamentals of Immunology” (Interscience Pub. Inc.; 2nd edit., 1947).
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BANKS, T., FRANCIS, G., MULLIGAN, W. et al. The Precipitin Reaction and Antibody Valence Studied with the Aid of Radioactive Isotopes. Nature 165, 111–112 (1950). https://doi.org/10.1038/165111b0
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DOI: https://doi.org/10.1038/165111b0
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