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Neuropeptide Y polymorphism significantly magnifies diabetes and cardiovascular disease risk in obesity: the Hoorn Study

European Journal of Clinical Nutrition volume 63, pages 150–152 (2009)Cite this article

Abstract

The leucine7 to proline7 (Leu7Pro) polymorphism in preproneuropeptide Y (preproNPY) has been associated with accelerated atherosclerosis and type II diabetes, both of which are obesity-related diseases. The current study evaluated the impact of obesity on the disease risk linked to the Leu7Pro polymorphism of preproNPY in 393 elderly subjects. In 6 years follow-up, the polymorphism alone did not change the risk for abnormal glucose regulation, while obesity was associated with a significant 3-fold risk (odds ratio (OR) 2.95; 95% confidence interval (CI) 1.81–4.81, P<0.001) and the Leu7Pro polymorphism–obesity interaction, with a remarkable 12-fold risk (OR 12.33; 95% CI 1.18–128.35, P<0.05). The Leu7Pro polymorphism modified significantly the 10-year incidence of cardiovascular events, causing a 7.6-fold increase in the hazard ratio (HR 7.58; 95% CI 2.87–20.03, P<0.001) in the obese but not in the nonobese subjects. The results indicate that obesity may be a pivotal factor in multiplying the disease risk associated with the Leu7Pro polymorphism in preproNPY.

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Acknowledgements

This study was financially supported by the Academy of Finland, EVO grants of Turku City Hospital and Turku University Hospital, the Finnish Diabetes Research Society, the Finnish Medical Society Duodecim, the Finnish Cultural Foundation and the Turku Graduate School of Clinical Sciences.

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Authors and Affiliations

  1. EMGO Institute, VU University Medical Center, Amsterdam, The Netherlands

    U Jaakkola, R J Heine, G Nijpels, L M Bouter & J M Dekker

  2. Centre for Biotechnology, University of Turku, Turku, Finland

    U Jaakkola & J Kallio

  3. Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands

    L M t' Hart & J A Maassen

  4. Department of Internal Medicine, Academic Hospital Maastricht, Maastricht, The Netherlands

    C D A Stehouwer

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  1. U Jaakkola
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  2. J Kallio
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  3. R J Heine
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  4. G Nijpels
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  5. L M t' Hart
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  6. J A Maassen
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  7. L M Bouter
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  8. C D A Stehouwer
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  9. J M Dekker
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Correspondence to U Jaakkola.

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Jaakkola, U., Kallio, J., Heine, R. et al. Neuropeptide Y polymorphism significantly magnifies diabetes and cardiovascular disease risk in obesity: the Hoorn Study. Eur J Clin Nutr 63, 150–152 (2009). https://doi.org/10.1038/sj.ejcn.1602964

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