Abstract
Objectives:
To observe the effect of fish oil supplementation on arterial elasticity and blood pressure (BP) in overweight hypertensive patients.
Subjects and methods:
This was a double-blind, randomized and placebo-controlled clinical study, in which 52 overweight hypertensive patients from a community were selected and randomly allocated to two groups (26 in the fish oil group (3 g day−1, fish oil capsules) and 26 in the placebo group (only capsules). All the subjects were follow-up for 8 weeks. The arterial elasticity was determined by CVProfilor DO-2020 and expressed as elasticity indexes (C1-large artery and C2-small artery). During the follow-up, totally nine cases were dropped out (three cases from the fish oil group and six cases from the placebo group).
Results:
After 8 weeks follow-up, the large artery elasticity in the fish oil group, compared with its baseline, was significantly improved (C1: 15.5±1.5 vs 12.8±3.7 ml mm Hg−1 × 10), whereas no effects were found in the placebo group (C1: 13.0±3.4 vs 13.4±3.8 ml mm Hg−1 × 10), P=0.027, RM-ANOVA across the two groups. The small artery elasticity (C2), BP and pulse pressure were not found any changes, either in the fish oil group or in the placebo group. At same time, the serum soluble vascular cell adhesion molecule-1(sVCAM-1) and leptin levels, the lipid profile and insulin sensitivity index (ISI) as well, did not show significant differences between two groups.
Conclusions:
Fish oil supplementation certainly would improve large arterial elasticity but no effect on BP in overweight hypertensive patients. Further study is needed to confirm the benefits of fish oil supplementation on age-related increases in arterial stiffness.
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References
Boutouyrie P, Tropeano AI, Asmar R, Gautier I, Benetos A, Lacolley P et al. (2002). Aortic stiffness is an independently predictor of primary coronary events in hypertensive patients: a longitudinal study. Hypertension 39, 10–15.
Burr ML, Fehily AM, Gilbert JF, Rogers S, Holliday RM, Sweetnam PM et al. (1989). Effects of changes in fat, fish, and fibre intakes on death and myocardial reinfarction trial (DART). Lancet 2, 757–761.
Chin JP, Gust AP, Nestel PJ, Dart AM (1993). Marine oils dose-dependently inhibit vasoconstriction of forearm resistance vessels in humans. Hypertension 21, 22–28.
De Deckere EAM, Korver O, Verschuren PM, Katan MB (1998). Health aspects of n-3 polyunsaturated fatty acids from plant and marine origin. Eur J Clin Nutr 52, 749–753.
Duprez DA, De Buyzere ML, Rietzschel ER, Taes Y, Clement DL, Morgan D et al. (1998). Inverse relationship between aldosterone and large artery compliance in chronically treated heart failure patients. Eur Heart J 19, 1371–1376.
Engler MM, Engler MB, Pierson DM, Molteni LB, Molteni A (2003). Effects of docosahexaenoic acid on vascular pathology and reactivity in hypertension. Exp Biol Med (Maywood) 228, 299–307.
GISSI-Prevenzione Investigators (1999). Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione Trial. Lancet 354, 447–455.
Kanazawa M, Yoshiike N, Osaka T, Numba Y, Zimmet P, Inoue S (2002). Criteria and classification of obesity in Japan and Asia-Oceania. Asia Pac J Clin Nutr 11, S732–S737.
Laurent S (1995). Arterial wall hypertrophy and stiffness in essential hypertensive patients. Hypertension 26, 355–362.
Laurent S, Boutouyrie P, Asmar R, Gautier I, Laloux B, Guize L et al. (2001a). Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients. Hypertension 37, 1236–1241.
Laurent S, Boutouyrie P, Asmar R, Gautier I, Laloux B, Guize L (2001b). Aortic stiffness is an independently predictor of all-cause and cardiovascular mortality in hypertensive patients. Hypertension 37, 1236–1241.
Laurent S, Boutouyrie P, Lacolley P (2005). Structural and genetic bases of arterial stiffness. Hypertension 45, 1050–1055.
London GM, Marchais SJ, Guerin AP (2004). Arterial stiffness and function in end-stage renal disease. Adv Chronic Kidney Dis 11, 202–209.
Miwa H, Yamamoto M, Nishida T, Nunoi K, Kikuchi M (1987). High-performance liquid chromatography analysis of serum long-chain fatty acids by direct derivatization method. J Chromatogr 416, 237–245.
McVeigh GE, Brennan GM, Cohn JN, Finkelstein SM, Hayes RJ, Johnston GD (1994). Fish oil improves arterial compliance in non-insulin dependent diabetes mellitus. Arterioscler Thromb 14, 1425–1429.
Miyajima T, Tsujino T, Saito K, Yokoyama M (2001). Effects of eicosapentaenoic acid on blood pressure, cell membrane fatty acids, and intracellular sodium concentration in essential hypertension. Hypertens Res 24, 537–542.
Mahmud A, Feely J (2005). Arterial stiffness is related to systemic inflammation in essential hypertension. Hypertension 46, 1118–1122.
Najjar SS, Scuteri A, Lakatta EG (2005). Arterial aging: is it an immutable cardiovascular risk factor? Hypertension 46, 454–462.
Nestel PJ, Pomeroy SE, Sashara T, Yamashita T, Yu LL, Dart AM et al. (1997). Arterial compliance in obese subjects is improved with dietary plant n-3 fatty acid from flaxseed oil despite increased LDL oxidizability. Arterioscler Thromb Vasc Biol 17, 1163–1170.
Nestel P, Shige H, Pomeroy S, Cehun M, Abbey M, Raederstorff D (2002). The n-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid increase systemic arterial compliance in humans. Am J Clin Nutr 76, 326–330.
O'Keefe Jr JH, Abuissa H, Sastre A, Steinhaus DM, Harris WS (2006). Effects of omega-3 fatty acids on resting heart rate recovery after exercise, and rate variability in men with heald myocardial in farctions and depressed ejection fractions. Am J Cardiol 97, 1127–1130.
Prisco D, Paniccia R, Bandinelli B, Filippini M, Francalanci I, Giusti B et al. (1998). Effect of medium-term supplementation with a moderate dose of n-3 polyunsaturated fatty acids on blood pressure in mild hypertensive patients. Thromb Res 91, 105–112.
Russo C, Olivieri O, Girelli D, Azzini M, Stanzial AM, Guarini P et al. (1995). Omega-3 polyunsaturated fatty acid supplements and ambulatory blood pressure monitoring parameters in patients with mild essential hypertension. J. Hypertens 13, 1823–1826.
Singhal A, Farooqi IS, Cole TJ, O'Rahilly S, Fewtrell M, Kattenhorn M et al. (2002). Influence of leptin on arterial distensibility: a novel link between obesity and cardiovascular disease? Circulation 106, 1919–1924.
Tomio H, Masanori N, Takayuki F, Yukari M, Atsuo I, Yoshinori D et al. (2002). Low serum eicosapentaenoic acid to arachidonic acid ratio is associated with arterial stiffness and frailty in community-dwelling elderly. Circulation 106 (Suppl 19), II.731–II.732.
The Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (2003). The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (the JNC 7 Report). JAMA 289, 2560–2572.
Wilkinson IB, Franklin SS, Cockcroft JR (2004). Nitric oxide and the regulation of large artery stiffness: from physiology to pharmacology. Hypertension 44, 112–116.
Acknowledgements
This work was supported by the Doctoral Foundation of Xi'an Jiaotong University (DFXJTU2004-13). We thank Professor Zhiquan Liu for revising this paper.
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Contributors: SW contributed to the study design, completing trial, determining arterial elasticity and writing paper. A-QM contributed to the quality control and paper modifications. S-WS and Q-HQ contributed in subjects' selection. X-FZ contributed in determining serum free fatty acid composition. X-ZH contributed to quality control.
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Wang, S., Ma, AQ., Song, SW. et al. Fish oil supplementation improves large arterial elasticity in overweight hypertensive patients. Eur J Clin Nutr 62, 1426–1431 (2008). https://doi.org/10.1038/sj.ejcn.1602886
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DOI: https://doi.org/10.1038/sj.ejcn.1602886
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