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Effect of moderate changes in dietary fatty acid profile on postprandial lipaemia, haemostatic and related CVD risk factors in healthy men

European Journal of Clinical Nutrition volume 58, pages 819–827 (2004)Cite this article

Abstract

Objective: To investigate the effect of moderate changes in dietary fatty acid profile on postprandial risk factors for cardiovascular disease (CVD).

Design: Double-blind, randomised, crossover, intervention trial.

Setting: University of Auckland Human Nutrition Unit, New Zealand.

Subjects: A total of 18 lean healthy men.

Interventions: A dairy butter fat modified to reduce the saturated:unsaturated fatty acid ratio and a conventional high saturated butter fat were given on two separate occasions as a high-fat test meal (59±4 g fat; 71 en% fat) at breakfast. A fat exclusion lunch, dinner and snacks were also given. Blood samples were collected at 0 (baseline), 1, 3, 6, 10 and 24 h.

Results: Maximum peak in total triacylglycerol (TAG) occurred 3 h postprandially and was highest on modified treatment (diet, P<0.05) due predominantly to increased TAG within the chylomicron-rich fraction. Transient peaks in total-, LDL- and HDL-cholesterol occurred postprandially, but did not differ between dietary treatments (P>0.05). There were no differential effects of diet on postprandial free fatty acids, apo A, apo B, glucose, insulin, amylin or haemostatic clotting factors (P>0.05).

Conclusions: In a group of healthy young men, replacement of 16% of total saturated fatty acids by mono- and polyunsaturated fats within a dairy lipid did not induce postprandial changes in CVD risk that may be considered beneficial for health.

Sponsorship: Fonterra, Wellington; New Zealand.

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Acknowledgements

We thank Glyn Muir who ran the metabolic kitchen during this trial. We are also grateful to Jenneke van Drunen, Esther de Swart and Joanna Lawrence for their considerable assistance during studentships. Cynthia Tse provided laboratory and administrative support throughout. We also thank the subjects who participated in this trial.

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Authors and Affiliations

  1. Department of Medicine, University of Auckland, New Zealand

    S D Poppitt & G J S Cooper

  2. Human Nutrition & Metabolic Unit, University of Auckland, New Zealand

    S D Poppitt & G F Keogh

  3. School of Biological Sciences, University of Auckland, New Zealand

    G F Keogh, T B Mulvey, A Phillips & G J S Cooper

  4. Department of Statistics, University of Auckland, New Zealand

    B H McArdle

  5. Fonterra Research Centre, Palmerston North, New Zealand

    A K H MacGibbon

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  1. S D Poppitt
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  2. G F Keogh
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Poppitt, S., Keogh, G., Mulvey, T. et al. Effect of moderate changes in dietary fatty acid profile on postprandial lipaemia, haemostatic and related CVD risk factors in healthy men. Eur J Clin Nutr 58, 819–827 (2004). https://doi.org/10.1038/sj.ejcn.1601882

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