Abstract
Aim: The purpose of this report is to survey the factors contributing to variation in lipoprotein(a) (Lp(a)) in a population-based sample of Anglo-Celtic Melburnians.
Results: The plasma Lp(a) levels were highly skewed towards low levels in this population, with a median of 156 mg/l and a mean of 262 mg/l. Approximately 33% had plasma Lp(a) above the threshold value of 300 mg/l, while 35% had Lp(a) levels below 100 mg/l. The most commonly occurring phenotype was apo(a) S3. In this phenotype, Lp(a) concentrations ranged from 10 to 596 mg/l. Lp(a) was consistently associated with diastolic blood pressure, systolic blood pressure, total protein, albumin and nitrogen excretion in the 40–60 y age group. Multiple stepwise regression analyses, in non-dietary factors, were used to explain about 13% of the variance in Lp(a) (19% in men and 23% in women). Remarkably, in the <40 y age group, non-dietary factors may account for 86% of the variance in Lp(a) and dietary factors, analysed separately, 46%. Thus, although Lp(a) is mainly genetically determined, there are clearly other factors which contribute to variations in Lp(a) concentrations.
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References
Albers, JJ, Wahl, P & Hazzard, WR (1974). Quantitative genetic studies of the human plasma Lp(a) lipoprotein. Biochem. Genet., 11, 475–486.
Albers, JJ, Cabana, VG, Warnick, GR & Hazzard, WR (1975). Lp(a) lipoproteins: relationship to sinking pre-B lipoprotein, hyperlipoproteinemia and apolipoprotein B. Metabolism, 24, 1047–1054.
Anderson, AJ, Sobocinski, KA, Freedman, DS, Barboriak, JJ, Rimm, AA & Gruchow, HW (1988). Body fat distribution, plasma lipids, and lipoproteins. Arteriosclerosis, 8, 88–94.
Anthony, MS, Clarkson, TB & Hughes, CL (1994). Plant mammalian estrogen on plasma lipids of female monkeys. Circulation, 90, (part 2)I-235
Cobbaert, C & Kesteloot, H (1992). Serum lipoprotein(a) levels in racially different populations. Am. J. Epidemiol., 136, 441–449.
Dahlen, GH, Guyton, JR, Attar, M, Farmer, JA, Kautz, JA, Gotto, AM & Phil, D (1986). Association of levels of lipoprotein Lp(a), plasma lipids, and other lipoproteins with coronary artery disease documented by angiography. Circulation, 74, 758–765.
Eldridge, AC (1982). Determination of isoflavones in soybean fours, protein concentrates and isolates. J. Agricult. Fd. Chem., 30, 353–355.
Eldridge, AC & Kwolek, WFJ (1983). Soya-bean isoflavones: effect of environment and variety on composition. J. Agricult. Fd. Chem., 31, 394–396.
Farmer, JA, Ballantyne, CM, Frazier, OH, Radovancevic, B, Payton-Ross, C, Patsch, W, Morrisett, JD, Gotto, AM Jr & Young, JB (1991). Lipoprotein(a) and apolipoprotein(a) changes after cardiac transplantation. J. Am. College Cardiol., 18, 926–930.
Guyton, JR, Dahlen, GH, Patsch, W, Kautz, JA & Gotto, AM (1985). Relationship of plasma lipoprotein Lp(a) levels to race and to apolipoprotein B. Arteriosclerosis, 5, 265–272.
Hajjar, KA, Gavish, D, Breslow, JL & Nachman, RL (1989). Lipoproteine(a) modulation of endothelial cell surface firbinolysis and its potential role in atherosclerosis. Nature, 339, 303–305.
Hearn, JA, DeMaio, SJ, Rouben, GS, Hammarstrom, M & Sgoutas, D (1990). Predictive value of lipoprotein(a) and other serum lipoproteins in the angiographic diagnosis of coronary artery disease. Am. J. Cardiol., 66, 1176–1180.
Heinrich, J, Sandkamp, M, Kokott, R, Schulte, H & Assmann, G (1991). Relationship of lipoprotein(a) to variables of coagulation and fibrinolysis in a healthy population. Clin. Chem., 37, 1950–1954.
Hoogeveen, RC, Gambhir, JK, Gambhir, DS, Kimball, KT, Ghazzaly, K, Gaubatz, JW, Vaduganathan, M, Rao, RS, Koschinaky, M & Morrisett, JD (2001). Evaluation of Lp(a) and other independent risk factors for CHD in Asian Indians and their USA counterparts. J. Lipid Res., 42, (4)631–638.
Huang, CM, Kraft, HG & Gregg, RE (1991). Modified immuno-blotting technique for phenotyping Lp(a). Clin. Chem., 37, 576–578.
Kervinen, K, Savolainen, MJ & Kesaniemi, YA (1991). A rapid increase in lipoprotein(a) levels after ethanol withdrawal in alcoholic men. Life Sci., 48, 2183–2188.
Kostner, GM (1993). Interaction of Lp(a) and of apo(a) with liver cells. Arterioscler. Thromb. Vasc. Biol., 13, 1101–1109.
Kostner, GM, Avogaro, P, Cazzolato, G, Marth, E, Bittolo-Bonn, G & Qunici, GB (1981). Lipoprotein Lp(a) and the risk for myocardial infarction. Atherosclerosis, 38, 51–61.
Kraft, HT, Menzel, H, Hoppichler, F, Vogel, W & Utermann, G (1989). Changes of genetic apolipoprotein phenotypes caused by liver transplantation: Implications for apolipoprotein synthesis. J. Clin. Invest., 83, 137–142.
Nikotin, YP, Tikhonov, AV & Grigorieva, IN (2001). Plasma lipoprotein(a) levels and Apo(a) isoforms in native population of Chukotka with and without arterial hypertension. Int. J. Circumpolar Health, 60, (2)216–221.
Parra, HJ, Luyeye, I, Bouramoue, C, Demarquilly, C & Fruchart, JC (1987). Black-white differences in serum Lp(a) levels. Clin. Chim. Acta, 168, 27–31.
Paultre, HF, Philbin, EF, Reed, RG & Berglund, L (2000). High levels of Lp(a) with a small isoform are associated with coronary artery disease in African American and white men. Arterioscler. Thromb. Vasc. Biol., 20, (12)2619–2624.
Paultre, F, Tuck, CH, Boden-Albala, B, Kargman, DE, Todd, E, Jones, J, Paik, MC, Sacco, RL & Berglund, L (2002). Relation of Apo(a) size to carotid atherosclerosis in an elderly multiethnic population. Arterioscler. Thromb. Vasc. Biol., 22, (1)141–146.
Potter, SM (1995). Overview of proposed mechanisms for the hypocholesterolemic effect of soy. J. Nutri., 125, (Suppl) 606–611s.
Scanu, AM & Fless, GM (1990). Lipoprotein(a) heterogeneity and biological relevance. J. Clin. Invest., 85, 1709–1715.
Steinmetz, A, Kirklies, A, Schlosser, G, Cassel, W, Peter, JH, Ehlenz, K, Schafer, R, Wichert, Pv & Kaffarnik, M (1993). Lipoprotein(a), low-density, intermediate-density lipoprotein, and blood pressure in a young male population. Clin. Invest., 71, 145–149.
Sundell, IB, Nilsson, TK, Hallmans, G, Hellsten, G & Dahlen, GH (1989). Interrelationships between plasma levels of plasminogen activator inhibitor, tissue plasminogen activator, lipoprotein(a), and established cardiovascular risk factors in a North Swedish population. Atherosclerosis, 80, 9–16.
Utermann, G (1989). The mysteries of lipoprotein(a). Science, 246, 904–910.
Utermann, G, Menzel, HJ, Kraft, HG, Duba, HC, Kemmler, HG & Seitz, C (1987). Lp(a) glycoprotein phenotypes: Inheritance and relation to Lp(a) lipoprotein concentrations in plams. J. Clin. Invest., 80, 458–465.
Valimaki, M, Laitinen, K, Ylikahri, R, Ehnholm, M, Jauhiainen, M, Bard, JM, Fruchart, JC & Taskinen, MR (1991). The effect of moderate alcohol intake on serum apolipoprotein A-I-containing lipoproteins and lipoprotein(a). Metabolism, 40, 1168–1172.
Verdeal, K & Ryan, D (1979). Naturally-occurring estrogens in plant foodstuffs—a review. J. Food Prot., 42, 577–583.
Wang, XL, Wilcken, DEL & Dudman, NPB (1992). Early expression of the apolipoprotein(a) gene: Relationships between infants' and their parents' serum apolipoprotein(a) levels. Pediatrics, 89, 401–406.
Werba, JP, Safa, O, Gianfranceschi, G, Michelagnoli, S, Sirtori, CR & Franceschini, G (1993). Plasma triglycerides and lipoprotein(a): inverse relationship in a hyperlipidemic Italian population. Atherosclerosis, 101, 203–211.
Wilkund, O, Angelin, B, Olufson, SO, Erisson, M, Fager, G, Berglund, L & Bonders, G (1990). Apolipoprotein(a) and ischaemic heart disease in familial hypercholesterolaemia. Lancet, 335, 1360–1363.
Wright, BM & Dore, CF (1970). A random-zero sphymomanometer. Lancet, 1, 337–338.
Xiong, ZW, Biegler, B, Hsu-hage, BH-H, Balazs, NDH & Wahlqvist, ML (1995). Lipoprotein (a) concentrations and apolipoprotein (a) phenotypes in a Melbourne adult Indian population. Clin. Biochem. Rev., 16, 66
Xiong, ZW, Wahlqvist, ML, Biegler, B, Balazs, NDH, Buynder, PV & Wattanapenpaiboon, N (2000). Plasma Lp(a) concentratioins and Apo(a) phenotypes in an Aboriginal population from Western Australia. Asia Pacific J. Clin. Nutr., 3, 235–241.
Xiong, G, Xiong, DW & Lim, YL (2002). Factors contributing to variation in lipoprotein(a) in a Melbourne Chinese population. Nutr. Res., 22, 553–565.
Acknowledgements
This work was supported by the Victorian Health Promotion Foundation, Australia, the Department of Medicine, Monash University, Melbourne, Australia and the Department of Clinical Biochemistry, Monash Medical Centre, Melbourne, Australia. The authors wish to thank Gayle Savige, R Tudball, M Daskalakis, BH-H Hsu-Hage, W Lukito, BJG Strauss and W Yu for their cooperation during the study.
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Guarantors: ZW Xiong.
Contributors: ZWX, MLW, BMB and NDHB were principal investigators of the project and contributed to wrting the manuscript, NTW collected the clinical data. DWX and YLL analysed data, corrected the manuscript and reviewed the paper.
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Xiong, Z., Wahlqvist, M., Wattanapenpaiboon, N. et al. Factors contributing to variation in lipoprotein (a) in Melbourne Anglo-Celtic population. Eur J Clin Nutr 57, 447–454 (2003). https://doi.org/10.1038/sj.ejcn.1601562
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DOI: https://doi.org/10.1038/sj.ejcn.1601562
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