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Nutrient intake in women with primary and secondary Sjögren's syndrome

European Journal of Clinical Nutrition volume 57, pages 328–334 (2003)Cite this article

Abstract

Objective: Recently, it has been proposed that dietary factors may contribute to the etiology and progression of Sjögren's syndrome, and that nutritional intervention may modify the severity of pathological abnormalities. The objective of this study was to determine whether the nutrient intake of women with primary (1°SS) or secondary (2°SS; ie with systemic lupus erythematosus (2°SS/SLE) or rheumatoid arthritis (2°SS/RA) Sjögren's syndrome is significantly different than that of age- and gender-matched controls.

Design: Women with Sjögren's syndrome were asked to complete the 97 General Purpose Semi-Quantitative Food Frequency Questionnaire, which consists of a list of 147 separate food items that represent the major sources of multiple nutrients. Nutritional data were evaluated in terms of absolute and energy-adjusted nutrient amounts and analyzed by ANOVA.

Results: Our results showed: (a) greater intake of energy, glutamate, carbohydrates, lactose, phosphorus, caffeine and unsupplemental thiamin and riboflavin in 1°SS, as well as supplemental calcium in 2°SS/SLE, compared with controls; (b) greater nutrient intake of energy, protein, glutamate, methionine, tryptophan, carbohydrates, lactose, supplemental calcium and phosphorus, sodium, caffeine and unsupplemental calcium, riboflavin and thiamin in 2°SS/RA, relative to 1°SS and/or 2°SS/SLE; (c) higher energy-adjusted values for supplemental calcium in 2°SS/SLE, and for vitamin A and supplemental iron and zinc in 2°SS/RA, compared with other groups; and (d) higher energy-adjusted intake of supplemental calcium, and a lower energy-adjusted intake of unsupplemental vitamin C, polyunsaturated fat, linoleic acid, omega-3 fatty acid, and specific other unsaturated fatty acids, in the Sjögren's syndrome group as a whole, relative to controls.

Conclusions: Our findings demonstrate that nutrient intake is altered in Sjögren's syndrome.

Sponsorship: This research was supported by a grant from Allergan Inc.

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Acknowledgements

The authors would like to thank Katherine Stack, Deborah Stutz, Laura Sampson, Lauren Wolfert, Benjamin D Sullivan and Dr Debra A. Schaumberg (Boston, MA, USA), and Dr Brenda Reis (Irvine, CA, USA), and the Sjogren's Syndrome Foundation (Jericho, NY, USA) for their assistance during these studies. This research was supported by a grant from Allergan, Inc.

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Author notes

  1. D A Sullivan: Guarantor: DA Sullivan.

  2. J M Cermak, A S Papas, R M Sullivan, M R Dana and D A Sullivan: Contributors: JMC coordinated the study and contributed to the study design, compilation of data, statistical analyses, interpretation of data and writing of the initial draft of the paper. ASP, RMS and MRD contributed to the recruitment of patients, conduct of the study, compilation of data or critical evaluation of the paper. DAS was responsible for the study, oversaw its conduct, performed the statistical analyses, interpreted the data and wrote the paper.

Authors and Affiliations

  1. Schepens Eye Research Institute, Boston, Massachusetts, USA

    J M Cermak, R M Sullivan, M R Dana & D A Sullivan

  2. Brigham and Women's Hospital, Boston, Massachusetts, USA

    J M Cermak & M R Dana

  3. Harvard Medical School, Boston, Massachusetts, USA

    J M Cermak, M R Dana & D A Sullivan

  4. Tufts University School of Dental Medicine, Boston, Massachusetts, USA

    A S Papas

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Correspondence to D A Sullivan.

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Cermak, J., Papas, A., Sullivan, R. et al. Nutrient intake in women with primary and secondary Sjögren's syndrome. Eur J Clin Nutr 57, 328–334 (2003). https://doi.org/10.1038/sj.ejcn.1601543

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