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Oral glutamine in paediatric oncology patients: a dose finding study

European Journal of Clinical Nutrition volume 57, pages 31–36 (2003)Cite this article

Abstract

Objective: The purpose of this study was to determine the most appropriate dose of oral glutamine to use in a further clinical study in paediatric oncology patients.

Design: This was a phase I, pharmokinetic study.

Setting: The study was carried out at The Yorkshire Regional Centre for Paediatric Oncology and Haematology, St James's University Hospital, Leeds, UK.

Subjects: Thirteen patients undergoing treatment for paediatric malignancy participated in this study. All 13 completed the study.

Interventions: The most appropriate dose was determined by patient acceptability and by plasma glutamine and ammonia levels measured at timed intervals after ingestion of a single glutamine dose.

Results: Doses of 0.35, 0.5 and 0.65 g/kg were well tolerated with no untoward plasma glutamine and ammonia levels. One patient was recruited to a higher dose of 0.75 g/kg, but the plasma glutamine and ammonia levels peaked at 2601 and 155 µmol/l, respectively. The ammonia level was greater than the acceptable upper limit. It was difficult to disperse the glutamine adequately at this dose, resulting in the suspension being found to be unpalatable and therefore no further patients were recruited at this dose.

Conclusion: It was concluded that 0.65 g/kg is a safe dose of glutamine to use in a clinical study in paediatric oncology patients.

Sponsorship: Scientific Hospital Supplies UK Ltd provided the L-glutamine and financial help for the biochemical analysis.

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Acknowledgements

We are grateful to SHS International for providing the L-glutamine and financial help for the biochemical analysis.

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Author notes

  1. E Ward and S Picton: Guarantor: S Picton and E Ward.

  2. E Ward, S Picton, U Reid, D Thomas, C Gardener, M Smith, M Henderson, V Holden and V Allgar: Contributors: EW initiated this study. The study design was developed in discussions involving the first 10 investigators. EW, UR, DT, CG and MS conducted the study. Data analysis was done by VA. All investigators were involved in discussions on data interpretation. The paper was written by EW and SP with contribution from MH.

Authors and Affiliations

  1. Yorkshire Regional Centre for Paediatric Oncology and Haematology, Leeds, UK

    S Picton, U Reid, D Thomas, C Gardener, S Kinsey & I Lewis

  2. Dietetic Department, St James's University Hospital, Leeds, UK

    E Ward

  3. Chemical Pathology Department, St James's University Hospital, Leeds, UK

    M Smith & M Henderson

  4. Pharmacy Department, St James's University Hospital, Leeds, UK

    V Holden

  5. Research and Development Department, St James's University Hospital, Leeds, UK

    V Allgar

Authors
  1. E Ward
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  2. S Picton
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  7. M Henderson
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  8. V Holden
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  9. S Kinsey
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  10. I Lewis
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  11. V Allgar
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Correspondence to E Ward.

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Ward, E., Picton, S., Reid, U. et al. Oral glutamine in paediatric oncology patients: a dose finding study. Eur J Clin Nutr 57, 31–36 (2003). https://doi.org/10.1038/sj.ejcn.1601517

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  • DOI: https://doi.org/10.1038/sj.ejcn.1601517

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