Abstract
MANY substances have been found to have anti-thyroid activity in the vertebrate body, some of them natural constituents of the body. But it has never been clear to what extent these substances exert their antithyroid properties in normal life. In this letter we report some results which have led us to the conclusion that the basal metabolic rate is normally controlled in the rat not by the concentration of the thyroid secretion in the internal medium alone but by interaction between this secretion and an anti-thyroid substance which we have identified as paraxanthine (1:7-dimethylxanthine). The results also give some indication of the nature of this interaction.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Carter, G. S., Brit. J. Exp. Biol., 10, 256 (1933).
Berichte, 39, 423 (1906).
Berichte, 31, 2622 (1898).
Z. Physiol. Chem., 24, 376 (1898).
J. Physiol., 66, 299 (1928).
J. Physiol., 68, 383 (1930).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
CARTER, G., MANN, F., HARLEY-MASON, J. et al. Paraxanthine as a Natural Antithyroid Substance. Nature 151, 728–730 (1943). https://doi.org/10.1038/151728c0
Issue Date:
DOI: https://doi.org/10.1038/151728c0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
