Abstract
THE lability of penicillin is such as to preclude most of the ordinary chemical manipulations. Attempts by us to purify the material by the procedure of E. P. Abraham and E. Chain1 had little success, perhaps for reasons which appear below. After a lengthy search, we have developed a new chromatographic technique involving a chemical reaction which for the first time provides a rapid means of concentrating penicillin to a high degree with the minimum risk of chemical change.
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References
Brit J. Exp. Path., 23, 103 (1942).
Florey et al., Lancet, 241, 177 (1941).
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CATCH, J., COOK, A. & HETXBRON, I. Purification and Chemistry of Penicillin. Nature 150, 633–634 (1942). https://doi.org/10.1038/150633b0
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DOI: https://doi.org/10.1038/150633b0
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