Abstract
IT is generally believed that aldehyde mutase (the enzyme which catalyses the dismutation of aldehydes in accordance with reaction (1)) is identical with aldehyde oxidase, which oxidizes aldehydes in accordance with reaction (2): where A may be O2, methylene blue or some other hydrogen acceptor. Wieland1 suggests that the oxidase normally uses a hydrogen acceptor to produce an oxidation of the aldehyde, but when no other acceptor is present it uses a second molecule of aldehyde as acceptor, reducing it to alcohol and so producing a dismutation of aldehyde (reaction 1).
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References
Wieland, H., Ber. deutsch. chem. Ges., 47, 2085 (1914).
Dixon, M., and Thurlow, S., Biochem. J., 18, 971 (1924).
Dixon, M., and Kodama, K., Biochem. J., 20, 1104 (1926).
Reichel, L., and Köhle, H., Z. physiol. Chem., 236, 145 (1935).
Euler, H. v., and Brunius, E., Z. physiol. Chem., 175, 52 (1928).
Lohmann, K., Biochem. Z., 254, 332 (1932).
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DIXON, M., LUTWAK-MANN, C. Aldehyde Mutase. Nature 139, 548–549 (1937). https://doi.org/10.1038/139548b0
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DOI: https://doi.org/10.1038/139548b0
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