Abstract
Stereotactic anterior capsulotomy in five patients with intractable obsessive compulsive disorder (OCD) resulted in progressive clinical improvement which correlated with serial magnetic resonance imaging evidence of progressive local and distant alterations in brain structures. Volumetric changes were noted in the caudate, mamillary body, thalamus, hippocampal formation, and the lesion site in the anterior limb of the internal capsule. These changes support the hypothesis of a neuroanatomic substrate for OCD.
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Taren, J., Curtis, G. & Gebarski, S. Structural Changes After Anterior Capsulotomy for Obsessive Compulsive Disorder. Neuropsychopharmacol 11, 287 (1994). https://doi.org/10.1038/sj.npp.1380220
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DOI: https://doi.org/10.1038/sj.npp.1380220