Abstract
The effects of sleeping pills are usually evaluated by interpretation of sleep polysograms but this takes much effort and time. We continuously took electroencephalograms of normal volunteers and aged patients with sleep and cerebrovascular disorders during sleep. After high-speed Fourier transformation, we divided the recordings at all electrodes into six bands, and prepared topography maps from the equivalent potential of each band. We examined if we could evaluate the effects of sleeping pills using topography maps at each stage of sleep. The equivalent potential height of each band during sleep was measured and displayed on a color scale at the same time as spectra for all six electrodes on the topography map. Changes in sleep with passage of time as shown by the trend graph drawn by CSA for the four electrodes (C3, C4, 01, and 02) were observed. As a result, the sleep-inducing effects of Zopiclone in normal volunteers and aged patients with cerebrovascular disorders could be evaluated using topography maps at each stage of sleep using maps made by color scale displays of equivalent potential in each band and spectra of the six electrodes as well as by polosography. Changes in sleep with passage of time could be observed on the trend graph. Normal volunteers given Zopiclone showed that equivalent potentials of δ and Ω bands were higher at ST3 and ST4. Aged patients with cerebrovascular disorders showed that equivalent potentials tended to be low.
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Katsunuma, H., Matsuda, H., Maehata, Y. et al. Study on Sleep Evaluation by Topography Mapping in Normal Volunteers and Aged Patients with Sleep and Cerebrovascular Disorders Following Administration of Zopiclone. Neuropsychopharmacol 11, 274 (1994). https://doi.org/10.1038/sj.npp.1380168
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DOI: https://doi.org/10.1038/sj.npp.1380168