Abstract
Predictors of tardive dyskinesia were determined utilizing data on 70 patients who have been followed longitudinally in an ongoing prospective study of first episode schizophrenics at Hillside Hospital. TD development was predicted by poorer level of remission from first psychotic episode, longer duration of psychotic symptoms prior to study entry, poorer levels of early adolescent social adjustment, frontal horn enlargement and global impairment on neuropsychological testing. Neuroleptic dose was a trend level predictor of TD development. When level of remission and dose as a time dependent covariate were entered simultaneously, level of remission remained a significant predictor of time to TD (risk ratio =7.34, 95%CI=1.75, 30.87, χ2=7.40, df=1, p=.007) while the effects of dose were eliminated (risk ratio per 2 fluphenazine units = 1.02,95% CI = 0.95, 1.09, χ2 =0.29, df=1, p=.59). Our findings suggest that TD development is primarily a consequence of disease related vulnerability which is manifest with drug exposure, rather than a consequence of increased drug exposure.
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Chakos, M., Alvir, J., Bilder, R. et al. Predictors of Tardive Dyskinesia in First Episode Schizophrenia. Neuropsychopharmacol 11, 267 (1994). https://doi.org/10.1038/sj.npp.1380141
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DOI: https://doi.org/10.1038/sj.npp.1380141