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MicroRNAs and chromosomal abnormalities in cancer cells

Oncogene volume 25, pages 6202–6210 (2006)Cite this article

Abstract

Over the past five decades, a plethora of nonrandom chromosomal abnormalities have been consistently reported in malignant cells facilitating the identification of cancer-associated protein coding oncogenes and tumor suppressors. The genetic dissection of hot spots for chromosomal abnormalities in the age of the sequenced human genome resulted in the discovery that microRNA (miRNA) genes, encoding for a class of small noncoding RNAs, frequently resides in such genomic regions. The combination of nonrandom chromosomal abnormalities and other types of genetic alterations or epigenetic events contribute to downregulation or overexpression of miRNAs. The consequent abnormal expression of miRNAs affect cell cycle, survival and differentiation programs and selective targeting of these noncoding genes could provide novel therapeutic options for killing the malignant cells.

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Abbreviations

Bcl-2:

B-cell leukemia/lymphoma 2 gene

CAGR:

cancer-associated genomic regions

CLL:

B-cell chronic lymphocitic leukemia

c-Myc:

v-myc myelocytomatosis viral oncogene homolog (avian) gene

HD:

homozygous deletion

FRA:

fragile sites

LOH:

loss of heterozygosity

miRNAs:

microRNAs

ncRNAs:

noncoding RNAs

OG(s):

oncogene(s)

TSG(s):

tumor-suppressor gene(s)

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Acknowledgements

We thank Terry Hyslop (Thomas Jefferson University, Philadelphia) for the statistical analyses presented here. Dr Croce is supported by Program Project Grants from the National Cancer Institute and Dr Calin by a Kimmel Foundation Scholar award and by the CLL Global Research Foundation. We apologize to many colleagues whose work was not cited due to space limitations.

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  1. Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, Ohio State University, Columbus, OH, USA

    G A Calin & C M Croce

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Correspondence to C M Croce.

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Calin, G., Croce, C. MicroRNAs and chromosomal abnormalities in cancer cells. Oncogene 25, 6202–6210 (2006). https://doi.org/10.1038/sj.onc.1209910

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