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Rb family proteins as modulators of gene expression and new aspects regarding the interaction with chromatin remodeling enzymes

Oncogene volume 25, pages 5263–5267 (2006)Cite this article

Abstract

The pRb family proteins (pRb1/105, p107, pRb2/p130), collectively referred to as pocket proteins, are believed to function primarily as regulators of the mammalian cell cycle progression, and suppressors of cellular growth and proliferation. In addition, different studies suggest that these pocket proteins are also involved in development and differentiation of various tissues. Several lines of evidence indicate that generally pRb-family proteins function through their effect on the transcription of E2F-regulated genes. In fact, each of Rb family proteins binds to distinct members of the E2F transcription factors, which regulate the expression of genes whose protein products are necessary for cell proliferation and to drive cell-cycle progression. Nevertheless, pocket proteins can affect the G1/S transition through E2F-independent mechanisms. More recently, a broad range of evidences indicate that pRb-family proteins associate with a wide variety of transcription factors and chromatin remodeling enzymes forming transcriptional repressor complexes that control gene expression. This review focuses on the complex regulatory mechanisms by which pRb-family proteins tell genes when to switch on and off.

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Acknowledgements

This study was supported in part by NIH grants, Sbarro Health Research Organization (WWW.SHRO.ORG) to Antonio Giordano. Marcella Macaluso is supported by a FIRC (Fondazione Italiana per la Ricerca sul Cancro) fellowship.

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Authors and Affiliations

  1. Sbarro Institute for Cancer Research and Molecular Medicine, Center of Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA, USA

    M Macaluso, M Montanari & A Giordano

  2. Department of Human Pathology and Oncology, University of Siena, Siena, Italy

    M Macaluso, M Montanari & A Giordano

  3. Department of Oncology, Section of Oncology,

    M Macaluso

  4. University of Palermo, Palermo, Italy

    M Macaluso

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  1. M Macaluso
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Correspondence to A Giordano.

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Macaluso, M., Montanari, M. & Giordano, A. Rb family proteins as modulators of gene expression and new aspects regarding the interaction with chromatin remodeling enzymes. Oncogene 25, 5263–5267 (2006). https://doi.org/10.1038/sj.onc.1209680

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