Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Review
  • Published:

Retinoblastoma family genes

Oncogene volume 25, pages 5190–5200 (2006)Cite this article

Abstract

The retinoblastoma gene Rb was the first tumor suppressor gene cloned, and it is well known as a negative regulator of the cell cycle through its ability to bind the transcription factor E2F and repress transcription of genes required for S phase. Although over 100 other proteins have been reported to interact with Rb, in most cases these interactions are much less well characterized. Therefore, this review will primarily focus on Rb and E2F interactions. In addition to cell cycle regulation, studies of Rb and E2F proteins in animal models have revealed important roles for these proteins in apoptosis and differentiation. Recent screens of Rb/E2F target genes have identified new targets in all these areas. In addition, the mechanisms determining how different subsets of target genes are regulated under different conditions have only begun to be addressed and offer exciting possibilities for future research.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1
Figure 2
Figure 3
Figure 4

Similar content being viewed by others

References

  • Apostolova MD, Ivanova IA, Dagnino C, D’Souza SJ, Dagnino L . (2002). J Biol Chem 277: 34471–34479.

  • Asano M, Nevins JR, Wharton RP . (1996). Genes Dev 10: 1422–1432.

  • Attwooll C, Denchi EL, Helin K . (2004a). EMBO J 23: 4709–4716.

  • Attwooll C, Oddi S, Cartwright P, Prosperini E, Agger K, Steensgaard P et al. (2004b). J Biol Chem 280: 1199–1208.

  • Bosco G, Du W, Orr-Weaver TL . (2001). Nat Cell Biol 3: 289–295.

  • Bracken AP, Ciro M, Cocito A, Helin K . (2004). Trends Biochem Sci 29: 409–417.

  • Brehm A, Miska EA, McCance DJ, Reid JL, Bannister AJ, Kouzarides T . (1998). Nature 391: 597–601.

  • Brugarolas J, Bronson RT, Jacks T . (1998). J Cell Biol 141: 503–514.

  • Caretti G, Salsi V, Vecchi C, Imbriano C, Mantovani R . (2003). J Biol Chem 278: 30435–30440.

  • Cayirlioglu P, Bonnette PC, Dickson MR, Duronio RJ . (2001). Development 128: 5085–5098.

  • Chau BN, Borges HL, Chen TT, Masselli A, Hunton IC, Wang JY . (2002). Nat Cell Biol 4: 757–765.

  • Chau BN, Wang JY . (2003). Nat Rev Cancer 3: 130–138.

  • Chellappan SP, Hiebert S, Mudryj M, Horowitz JM, Nevins JR . (1991). Cell 65: 1053–1061.

  • Chen CR, Kang Y, Siegel PM, Massague J . (2002). Cell 110: 19–32.

  • Classon M, Harlow E . (2002). Nat Rev Cancer 2: 910–917.

  • Cloud JE, Rogers C, Reza TL, Ziebold U, Stone JR, Picard MH et al. (2002). Mol Cell Biol 22: 2663–2672.

  • Cobrinik D, Lee MH, Hannon G, Mulligan G, Bronson RT, Dyson N et al. (1996). Genes Dev 10: 1633–1644.

  • Dannenberg JH, Schuijff L, Dekker M, van der Valk M, te Riele H . (2004). Genes Dev 18: 2952–2962.

  • Dannenberg JH, van Rossum A, Schuijff L, te Riele H . (2000). Genes Dev 14: 3051–3064.

  • de Bruin A, Maiti B, Jakoi L, Timmers C, Buerki R, Leone G . (2003a). J Biol Chem 278: 42041–42049.

  • de Bruin A, Wu L, Saavedra HI, Wilson P, Yang Y, Rosol TJ et al. (2003b). Proc Natl Acad Sci USA 100: 6546–6551.

  • de Nooij JC, Letendre MA, Hariharan IK . (1996). Cell 87: 1237–1247.

  • Di Stefano L, Jensen MR, Helin K . (2003). EMBO J 22: 6289–6298.

  • Dimova DK, Stevaux O, Frolov MV, Dyson NJ . (2003). Genes Dev 17: 2308–2320.

  • Du W . (2000). Development 127: 367–379.

  • Du W, Dyson N . (1999). EMBO J 18: 916–925.

  • Du W, Vidal M, Xie JE, Dyson N . (1996a). Genes Dev 10: 1206–1218.

  • Du W, Xie JE, Dyson N . (1996b). EMBO J 15: 3684–3692.

  • Dunaief JL, Strober BE, Guha S, Khavari PA, Alin K, Luban J et al. (1994). Cell 79: 119–130.

  • Duronio RJ, Bonnette PC, O’Farrell PH . (1998). Mol Cell Biol 18: 141–151.

  • Duronio RJ, O’Farrell PH, Xie JE, Brook A, Dyson N . (1995). Genes Dev 9: 1445–1455.

  • Dynlacht BD, Brook A, Dembski M, Yenush L, Dyson N . (1994a). Proc Natl Acad Sci USA 91: 6359–6363.

  • Dynlacht BD, Flores O, Lees JA, Harlow E . (1994b). Genes Dev 8: 1772–1786.

  • Dyson N . (1998). Genes Dev 12: 2245–2262.

  • Ewen ME, Sluss HK, Sherr CJ, Matsushime H, Kato J, Livingston DM . (1993). Cell 73: 487–497.

  • Ferreira R, Naguibneva I, Mathieu M, Ait-Si-Ali S, Robin P, Pritchard LL et al. (2001). EMBO Rep 2: 794–799.

  • Field SJ, Tsai FY, Kuo F, Zubiaga AM, Kaelin Jr WG, Livingston DM et al. (1996). Cell 85: 549–561.

  • Firth LC, Baker NE . (2005). Dev Cell 8: 541–551.

  • Follette PJ, Duronio RJ, O’Farrell PH . (1998). Curr Biol 8: 235–238.

  • Frolov MV, Dyson NJ . (2004). J Cell Sci 117: 2173–2181.

  • Frolov MV, Huen DS, Stevaux O, Dimova D, Balczarek-Strang K, Elsdon M et al. (2001). Genes Dev 15: 2146–2160.

  • Frolov MV, Stevaux O, Moon NS, Dimova D, Kwon EJ, Morris EJ et al. (2003). Genes Dev 17: 723–728.

  • Gaubatz S, Lees JA, Lindeman GJ, Livingston DM . (2001). Mol Cell Biol 21: 1384–1392.

  • Giangrande PH, Hallstrom TC, Tunyaplin C, Calame K, Nevins JR . (2003). Mol Cell Biol 23: 3707–3720.

  • Giangrande PH, Zhu W, Rempel RE, Laakso N, Nevins JR . (2004). EMBO J 23: 1336–1347.

  • Gu W, Schneider JW, Condorelli G, Kaushal S, Mahdavi V, Nadal-Ginard B . (1993). Cell 72: 309–324.

  • Hallstrom TC, Nevins JR . (2003). Proc Natl Acad Sci USA 100: 10848–10853.

  • Hernando E, Nahle Z, Juan G, Diaz-Rodriguez E, Alaminos M, Hemann M et al. (2004). Nature 430: 797–802.

  • Hinds PW, Mittnacht S, Dulic V, Arnold A, Reed SI, Weinberg RA . (1992). Cell 70: 993–1006.

  • Iavarone A, King ER, Dai XM, Leone G, Stanley ER, Lasorella A . (2004). Nature 432: 1040–1045.

  • Jacks T, Fazeli A, Schmitt EM, Bronson RT, Goodell MA, Weinberg RA . (1992). Nature 359: 295–300.

  • Jost CA, Ginsberg D, Kaelin Jr WG . (1996). Virology 220: 78–90.

  • Kang H, Cui K, Zhao K . (2004). Mol Cell Biol 24: 1188–1199.

  • Kato J, Matsushime H, Hiebert SW, Ewen ME, Sherr CJ . (1993). Genes Dev 7: 331–342.

  • Knoblich JA, Sauer K, Jones L, Richardson H, Saint R, Lehner CF . (1994). Cell 77: 107–120.

  • Korenjak M, Taylor-Harding B, Binne UK, Satterlee JS, Stevaux O, Aasland R et al. (2004). Cell 119: 181–193.

  • Landsberg RL, Sero JE, Danielian PS, Yuan TL, Lee EY, Lees JA . (2003). Proc Natl Acad Sci USA 100: 2456–2461.

  • Lane ME, Sauer K, Wallace K, Jan YN, Lehner CF, Vaessin H . (1996). Cell 87: 1225–1235.

  • Lasorella A, Noseda M, Beyna M, Yokota Y, Iavarone A . (2000). Nature 407: 592–598.

  • Lasorella A, Rothschild G, Yokota Y, Russell RG, Iavarone A . (2005). Mol Cell Biol 25: 3563–3574.

  • Lee EY, Cam H, Ziebold U, Rayman JB, Lees JA, Dynlacht BD . (2002). Cancer Cell 2: 463–472.

  • Liu DX, Nath N, Chellappan SP, Greene LA . (2005). Genes Dev 19: 719–732.

  • MacLellan WR, Xiao G, Abdellatif M, Schneider MD . (2000). Mol Cell Biol 20: 8903–8915.

  • Maiti B, Li J, de Bruin A, Gordon F, Timmers C, Opavsky R et al. (2005). J Biol Chem 280: 18211–18220.

  • Masselli A, Wang JY . (2006). Oncogene 25: 1290–1298.

  • Miyake S, Sellers WR, Safran M, Li X, Zhao W, Grossman SR et al. (2000). Mol Cell Biol 20: 8889–8902.

  • Moon NS, Frolov MV, Kwon EJ, Di Stefano L, Dimova DK, Morris EJ et al. (2005). Dev Cell 9: 463–475.

  • Morris EJ, Dyson NJ . (2001). Adv Cancer Res 82: 1–54.

  • Muller H, Bracken AP, Vernell R, Moroni MC, Christians F, Grassilli E et al. (2001). Genes Dev 15: 267–285.

  • Muller H, Moroni MC, Vigo E, Petersen BO, Bartek J, Helin K . (1997). Mol Cell Biol 17: 5508–5520.

  • Mundle SD, Saberwal G . (2003). FASEB J 17: 569–574.

  • Narita M, Nunez S, Heard E, Lin AW, Hearn SA, Spector DL et al. (2003). Cell 113: 703–716.

  • Neufeld TP, de la Cruz AF, Johnston LA, Edgar BA . (1998). Cell 93: 1183–1193.

  • Nguyen DX, Baglia LA, Huang SM, Baker CM, McCance DJ . (2004). EMBO J 23: 1609–1618.

  • Nguyen DX, McCance DJ . (2005). J Cell Biochem 94: 870–879.

  • Nielsen SJ, Schneider R, Bauer UM, Bannister AJ, Morrison A, O’Carroll D et al. (2001). Nature 412: 561–565.

  • Ohtani K, Nevins JR . (1994). Mol Cell Biol 14: 1603–1612.

  • Park MS, Rosai J, Nguyen HT, Capodieci P, Cordon-Cardo C, Koff A . (1999). Proc Natl Acad Sci USA 96: 6382–6387.

  • Pediconi N, Ianari A, Costanzo A, Belloni L, Gallo R, Cimino L et al. (2003). Nat Cell Biol 5: 552–558.

  • Polager S, Kalma Y, Berkovich E, Ginsberg D . (2002). Oncogene 21: 437–446.

  • Rayman JB, Takahashi Y, Indjeian VB, Dannenberg JH, Catchpole S, Watson RJ et al. (2002). Genes Dev 16: 933–947.

  • Ren B, Cam H, Takahashi Y, Volkert T, Terragni J, Young RA et al. (2002). Genes Dev 16: 245–256.

  • Resnitzky D, Hengst L, Reed SI . (1995). Mol Cell Biol 15: 4347–4352.

  • Robanus-Maandag E, Dekker M, van der Valk M, Carrozza ML, Jeanny JC, Dannenberg JH et al. (1998). Genes Dev 12: 1599–1609.

  • Robertson KD, Ait-Si-Ali S, Yokochi T, Wade PA, Jones PL, Wolffe AP . (2000). Nat Genet 25: 338–342.

  • Royzman I, Austin RJ, Bosco G, Bell SP, Orr-Weaver TL . (1999). Genes Dev 13: 827–840.

  • Royzman I, Whittaker AJ, Orr-Weaver TL . (1997). Genes Dev 11: 1999–2011.

  • Ruiz S, Santos M, Segrelles C, Leis H, Jorcano JL, Berns A et al. (2004). Development 131: 2737–2748.

  • Saavedra HI, Wu L, de Bruin A, Timmers C, Rosol TJ, Weinstein M et al. (2002). Cell Growth Differ 13: 215–225.

  • Sage C, Huang M, Karimi K, Gutierrez G, Vollrath MA, Zhang DS et al. (2005). Science 307: 1114–1118.

  • Sage J, Miller AL, Perez-Mancera PA, Wysocki JM, Jacks T . (2003). Nature 424: 223–228.

  • Sage J, Mulligan GJ, Attardi LD, Miller A, Chen S, Williams B et al. (2000). Genes Dev 14: 3037–3050.

  • Sawado T, Yamaguchi M, Nishimoto Y, Ohno K, Sakaguchi K, Matsukage A . (1998). Biochem Biophys Res Commun 251: 409–415.

  • Shirodkar S, Ewen M, DeCaprio JA, Morgan J, Livingston DM, Chittenden T . (1992). Cell 68: 157–166.

  • Spike BT, Dirlam A, Dibling BC, Marvin J, Williams BO, Jacks T et al. (2004). EMBO J 23: 4319–4329.

  • Stevaux O, Dimova D, Frolov MV, Taylor-Harding B, Morris E, Dyson N . (2002). EMBO J 21: 4927–4937.

  • Stevaux O, Dimova DK, Ji JY, Moon NS, Frolov MV, Dyson NJ . (2005). Cell Cycle 4: 1272–1280.

  • Takahashi Y, Rayman JB, Dynlacht BD . (2000). Genes Dev 14: 804–816.

  • Taubert S, Gorrini C, Frank SR, Parisi T, Fuchs M, Chan HM et al. (2004). Mol Cell Biol 24: 4546–4556.

  • Trimarchi JM, Fairchild B, Verona R, Moberg K, Andon N, Lees JA . (1998). Proc Natl Acad Sci USA 95: 2850–2855.

  • Trimarchi JM, Fairchild B, Wen J, Lees JA . (2001). Proc Natl Acad Sci USA 98: 1519–1524.

  • Tsai KY, Hu Y, Macleod KF, Crowley D, Yamasaki L, Jacks T . (1998). Mol Cell 2: 293–304.

  • Verona R, Moberg K, Estes S, Starz M, Vernon JP, Lees JA . (1997). Mol Cell Biol 17: 7268–7282.

  • Wells J, Yan PS, Cechvala M, Huang T, Farnham PJ . (2003). Oncogene 22: 1445–1460.

  • Weng L, Zhu C, Xu J, Du W . (2003). EMBO J 22: 3865–3875.

  • Wikenheiser-Brokamp KA . (2004). Development 131: 4299–4310.

  • Wu L, de Bruin A, Saavedra HI, Starovic M, Trimboli A, Yang Y et al. (2003). Nature 421: 942–947.

  • Wu L, Timmers C, Maiti B, Saavedra HI, Sang L, Chong GT et al. (2001). Nature 414: 457–462.

  • Yamasaki L, Bronson R, Williams BO, Dyson NJ, Harlow E, Jacks T . (1998). Nat Genet 18: 360–364.

  • Yamasaki L, Jacks T, Bronson R, Goillot E, Harlow E, Dyson NJ . (1996). Cell 85: 537–548.

  • Young AP, Longmore GD . (2004). Oncogene 23: 814–823.

  • Zhang HS, Gavin M, Dahiya A, Postigo AA, Ma D, Luo RX et al. (2000). Cell 101: 79–89.

  • Zheng N, Fraenkel E, Pabo CO, Pavletich NP . (1999). Genes Dev 13: 666–674.

  • Zhou L, Steller H . (2003). Dev Cell 4: 599–605.

  • Zhu JW, Field SJ, Gore L, Thompson M, Yang H, Fujiwara Y et al. (2001). Mol Cell Biol 21: 8547–8564.

  • Zhu L, Harlow E, Dynlacht BD . (1995). Genes Dev 9: 1740–1752.

  • Ziebold U, Lee EY, Bronson RT, Lees JA . (2003). Mol Cell Biol 23: 6542–6552.

  • Ziebold U, Reza T, Caron A, Lees JA . (2001). Genes Dev 15: 386–391.

Download references

Acknowledgements

We thank Dr Kay Macleod for reading of this paper. This work is supported by grants from NIH and ACS to WD. WD is a Scholar of the Leukemia and Lymphoma Society.

Author information

Authors and Affiliations

  1. Ben May Institute for Cancer Research and Center for Molecular Oncology, University of Chicago, Chicago, IL, USA

    W Du & J Pogoriler

Authors
  1. W Du
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J Pogoriler
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to W Du.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Du, W., Pogoriler, J. Retinoblastoma family genes. Oncogene 25, 5190–5200 (2006). https://doi.org/10.1038/sj.onc.1209651

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.onc.1209651

Keywords

This article is cited by

Search

Advanced search

Quick links