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ADAM12 is highly expressed in carcinoma-associated stroma and is required for mouse prostate tumor progression

Abstract

The interaction between stromal cells and tumor cells is emerging as a critical aspect of tumor progression. Yet there is a paucity of molecular markers for cells participating in such interactions, and only few genes are known to play a critical role in this process. Here, we describe the identification of ADAM12 (a disintegrin and metalloprotease 12) as a novel marker for a subpopulation of stromal cells that are adjacent to epithelial tumor cells in three mouse carcinoma models (models for prostate, breast and colon cancer). Moreover, we show that ADAM12 is essential for tumor development and progression in the W10 mouse model for prostate cancer. These results suggest that ADAM12 might be a useful marker for stromal cells in mouse tumors that are likely to participate in stromal/tumor cell crosstalk, and that ADAM12 is a potential target for design of drugs that prevent carcinoma growth.

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Acknowledgements

We thank Dr A Koff for W10 mice, Drs B Fingleton and L Matrisian for tumors from MMTV-PyMT and Apc/Min/+ mice, and Brian Hutchinson and Katia Bozhilova for excellent technical assistance. This investigation was conducted in a facility constructed with support from Research Facilities Improvement Program Grant Number C06-RR12538-01 from the National Center for Research Resources, National Institutes of Health. Financial Support was provided by the Koch and Pepsico Funds to CPB, HS and LP, and by NIH-GM64750 to CPB.

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Correspondence to C P Blobel.

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Peduto, L., Reuter, V., Sehara-Fujisawa, A. et al. ADAM12 is highly expressed in carcinoma-associated stroma and is required for mouse prostate tumor progression. Oncogene 25, 5462–5466 (2006). https://doi.org/10.1038/sj.onc.1209536

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