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Human T-cell leukemia/lymphoma virus type 1 nonstructural genes and their functions

Oncogene volume 24, pages 6026–6034 (2005)Cite this article

Abstract

The human T-cell leukemia/lymphoma virus (HTLV) genome, in addition to the structural Gag and Env proteins and retroviral enzymes, carries a region at its 3′ end originally designated pX. To date, we know that this region encodes two essential transcriptional and post-transcriptional positive regulators of viral expression, the Tax and Rex proteins, respectively (reviewed elsewhere in this issue). Here, we will review current knowledge of the functions of three additional proteins encoded in the pX region, p12I, p13II, and p30II.

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Acknowledgements

We thank DM D'Agostino and MD Lairmore for discussions and sharing unpublished data, and Steven J Snodgrass for editorial assistance. V Ciminale's research was supported by grants from the National Institutes of Health-Fogarty International Center, the Ministero dell'Istruzione, dell'Università e della Ricerca, the Associazione and Fondazione Italiana per la Ricerca sul Cancro, and the Istituto Superiore di Sanità AIDS Program.

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Authors and Affiliations

  1. Department of Microbiology, University of Kansas Medical Center, Molecular Genetics, and Immunology, 3025 Wahl Hall West, 3901 Rainbow Boulevard, Kansas City, 66160-7420, KS, USA

    Christophe Nicot

  2. Department of Biological Sciences, Southern Methodist University, Laboratory of Molecular Virology, 334-DLS, 6501 Airline Drive, Dallas, 75275-0376, TX, USA

    Robert L Harrod

  3. Department of Oncology & Surgical Sciences, University of Padova, Oncology Section, Padova, 35128, Via Gattamelata, 64, Italy

    Vincenzo Ciminale

  4. National Cancer Institute, Animal Models & Retroviral Vaccines Section, 41/D804, Bethesda, 20892-5065, MD, USA

    Genoveffa Franchini

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  1. Christophe Nicot
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  4. Genoveffa Franchini
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Correspondence to Genoveffa Franchini.

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Nicot, C., Harrod, R., Ciminale, V. et al. Human T-cell leukemia/lymphoma virus type 1 nonstructural genes and their functions. Oncogene 24, 6026–6034 (2005). https://doi.org/10.1038/sj.onc.1208977

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