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Genetic alterations of the KLF6 gene in gastric cancer

Oncogene volume 24, pages 4588–4590 (2005)Cite this article

Abstract

The KLF6 is a zinc-finger tumor suppressor that is frequently mutated in several human cancers and broadly involved in differentiation and development, growth-related signal transduction, cell proliferation, apoptosis, and angiogenesis. To determine whether genetic alterations of KLF6 gene are involved in the development and/or progression of gastric cancer, we have screened a set of 80 sporadic gastric cancers for mutations and allele loss of the KLF6 gene. Four missense mutations, S155R, P172 T, S180L, and R198 K, were detected in transactivation domain of the KLF6 gene and one of them had biallelic mutations with somatic mutation of one allele and loss of the remaining allele. All of the cases with mutation were of advanced intestinal-type gastric cancer with lymph node metastasis. In addition, 16 (43.2%) of 37 informative cases showed allelic loss at KLF6 locus. Interestingly, allelic loss was also frequent in intestinal-type gastric cancer. Therefore, our data suggest that genetic alterations of KLF6 gene might play an important role in the development or progression of sporadic gastric cancers.

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Acknowledgements

This work was supported by the Korea Science & Engineering Foundation (KOSEF) through the Cell Death Disease Research Center at The Catholic University of Korea.

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Authors and Affiliations

  1. Department of Pathology, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Seocho-gu, Seoul, 137-701, Korea

    Yong Gu Cho, Chang Jae Kim, Su Young Kim, Suk Woo Nam, Sug Hyung Lee, Nam Jin Yoo, Jung Young Lee & Won Sang Park

  2. Department of Pathology Surgery, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Seocho-gu, Seoul, 137-701, Korea

    Cho Hyun Park

  3. Genetic Laboratory of Premedical Course, Kon-Kuk University College of Medicine, Chungju, 380-701, Korea

    Young Mok Yang

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  1. Yong Gu Cho
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Correspondence to Won Sang Park.

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Cho, Y., Kim, C., Park, C. et al. Genetic alterations of the KLF6 gene in gastric cancer. Oncogene 24, 4588–4590 (2005). https://doi.org/10.1038/sj.onc.1208670

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