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The Plk3-Cdc25 circuit

Abstract

Polo-like kinases (Plks) are key regulators of the cell cycle, especially in the G2 phase and mitosis. They are incorporated into signaling networks that regulate many aspects of the cell cycle, including but not limited to centrosome maturation and separation, mitotic entry, chromosome segregation, mitotic exit, and cytokinesis. The Plks have well conserved 30-amino-acid elements, designated polo boxes (PBs), located in their carboxyl-termini, which with their flanking regions constitute a functional Polo-box domain (PBD). Members of the Plk family exist in a variety of organisms including Polo in Drosophila melanogaster; Cdc5 in Saccharomyces cerevisiae; Plo1 in Schizosaccharomyces pombe; Plx1 in Xenopus laevis; and Plk1, Snk/Plk2, Fnk/Prk/Plk3, and Sak in mammals. Polo, Cdc5, and Plo1 are essential for viability. The Plks can be separated into two groups according to their functions. The first group (Polo, Cdc5, plo1, Plx1, and Plk1) primarily performs mitotic functions, whereas the second group (Plk2 and Plk3) appears to have additional functions during the G1, S, and G2 phases of the cell cycle. Several contributions to this issue will discuss different aspects of Plk involvement in cell-cycle regulation. This review, therefore, will focus on the role of Plk3 in regulating Cdc25 phosphatase function and its effect on the cell cycle.

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References

  • Abrieu A, Brassac T, Galas S, Fisher D, Labbe JC and Doree M . (1998). J. Cell Sci., 111, 1751–1757.

  • Alexandru G, Uhlmann F, Mechtler K, Poupart MA and Nasmyth K . (2001). Cell, 105, 459–472.

  • Altschul SF, Gish W, Miller W, Myers EW and Lipman DJ . (1990). J. Mol. Biol., 215, 403–410.

  • Atherton-Fessler S, Parker LL, Geahlen RL and Piwnica-Worms H . (1993). Mol. Cell. Biol., 13, 1675–1685.

  • Bahassi El M, Conn CW, Myer DL, Hennigan RF, McGowan CH, Sanchez Y and Stambrook PJ . (2002). Oncogene, 21, 6633–6640.

  • Bahassi El M, Hennigan RF, Myer DL and Stambrook PJ . (2004). Oncogene, 23, 2658–2663.

  • Bartholomew CR, Woo SH, Chung YS, Jones C and Hardy CF . (2001). Mol. Cell. Biol., 21, 4949–4959.

  • Bernardi R, Liebermann DA and Hoffman B . (2000). Oncogene, 19, 2447–2454.

  • Blomberg I and Hoffmann I . (1999). Mol. Cell. Biol., 19, 6183–6194.

  • Booher RN, Holman PS and Fattaey A . (1997). J. Biol. Chem., 272, 22300–22306.

  • Brassac T, Castro A, Lorca T, Le Peuch C, Doree M, Labbe JC and Galas S . (2000). Oncogene, 19, 3782–3790.

  • Busino L, Donzelli M, Chiesa M, Guardavaccaro D, Ganoth D, Dorrello NV, Hershko A, Pagano M and Draetta GF . (2003). Nature, 426, 87–91.

  • Charles J, Jaspersen S, Tinker-Kulberg R, Hwang L, Szidon A and Morgan D . (1998). Curr. Biol., 8, 497–507.

  • Chase D, Feng Y, Hanshew B, Winkles JA, Longo DL and Ferris DK . (1998). Biochem. J., 333, 655–660.

  • Chen MS, Hurov J, White LS, Woodford-Thomas T and Piwnica-Worms H . (2001). Mol. Cell. Biol., 21, 3853–3861.

  • Chen MS, Ryan CE and Piwnica-Worms H . (2003). Mol. Cell. Biol., 23, 7488–7497.

  • Cheng KY, Lowe ED, Sinclair J, Nigg EA and Johnson LN . (2003). EMBO J., 22, 5757–5768.

  • Cogswell JP, Brown CE, Bisi JE and Neill SD . (2000). Cell Growth Differ., 11, 615–623.

  • Conn CW, Hennigan RF, Dai W, Sanchez Y and Stambrook PJ . (2000). Cancer Res., 60, 6826–6831.

  • Dai W, Li Y, Ouyang B, Pan H, Reissmann P, Li J, Wiest J, Stambrook P, Gluckman JL, Noffsinger A and Bejarano P . (2000). Genes Chromosomes Cancer, 27, 332–336.

  • Dalal SN, Schweitzer CM, Gan J and DeCaprio JA . (1999). Mol. Cell. Biol., 19, 4465–4479.

  • Donohue PJ, Alberts GF, Guo Y and Winkles JA . (1995). J. Biol. Chem., 270, 10351–10357.

  • Donzelli M, Squatrito M, Ganoth D, Hershko A, Pagano M and Draetta GF . (2002). EMBO J., 21, 4875–4884.

  • Draetta G and Eckstein J . (1997). Biochim. Biophys. Acta, 1332, M53–M56.

  • Elia AE, Cantley LC and Yaffe MB . (2003). Science, 299, 1190–1191.

  • Falck J, Mailand N, Syljuasen RG, Bartek J and Lukas J . (2001). Nature, 410, 842–847.

  • Fauman EB, Cogswell JP, Lovejoy B, Rocque WJ, Holmes W, Montana VG, Piwnica-Worms H, Rink MJ and Saper MA . (1998). Cell, 93, 617–625.

  • Galaktionov K and Beach D . (1991). Cell, 67, 1181–1194.

  • Galaktionov K, Chen X and Beach D . (1996). Nature, 382, 511–517.

  • Gautier J and Maller JL . (1991). EMBO J., 10, 177–182.

  • Giles N, Forrest A and Gabrielli B . (2003). J. Biol. Chem., 278, 28580–28587.

  • Golan A, Yudkovsky Y and Hershko A . (2002). J. Biol. Chem., 277, 15552–15557.

  • Gould KL, Moreno S, Tonks NK and Nurse P . (1990). Science, 250, 1573–1576.

  • Graves PR, Lovly CM, Uy GL and Piwnica-Worms H . (2001). Oncogene, 20, 1839–1851.

  • Graves PR, Yu L, Schwarz JK, Gales J, Sausville EA, O'Connor PM and Piwnica-Worms H . (2000). J. Biol. Chem., 275, 5600–5605.

  • Hartwell LH, Culotti J, Pringle JR and Reid BJ . (1974). Science, 183, 46–51.

  • Hartwell LH and Weinert TA . (1989). Science, 246, 629–634.

  • Hoffmann I, Clarke PR, Marcote MJ, Karsenti E and Draetta G . (1993). EMBO J., 12, 53–63.

  • Hoffmann I, Draetta G and Karsenti E . (1994). EMBO J., 13, 4302–4310.

  • Holtrich U, Wolf G, Yuan J, Bereiter-Hahn J, Karn T, Weiler M, Kauselmann G, Rehli M, Andreesen R, Kaufmann M, Kuhl D and Strebhardt K . (2000). Oncogene, 19, 4832–4839.

  • Honda R, Ohba Y, Nagata A, Okayama H and Yasuda H . (1993). FEBS Lett., 318, 331–334.

  • Hudson JW, Kozarova A, Cheung P, Macmillan JC, Swallow CJ, Cross JC and Dennis JW . (2001). Curr. Biol., 11, 441–446.

  • Izumi T and Maller JL . (1995). Mol. Cell. Biol., 6, 215–226.

  • Izumi T, Walker DH and Maller JL . (1992). Mol. Cell. Biol., 3, 927–939.

  • Jaspersen SL, Charles JF, Tinker-Kulberg RL and Morgan DO . (1998). Mol. Cell. Biol., 9, 2803–2817.

  • Karaiskou A, Lepretre AC, Pahlavan G, Du Pasquier D, Ozon R and Jessus C . (2004). Development, 131, 1543–1552.

  • Kauselmann G, Weiler M, Wulff P, Jessberger S, Konietzko U, Scafidi J, Staubli U, Bereiter-Hahn J, Strebhardt K and Kuhl D . (1999). EMBO J., 18, 5528–5539.

  • Keyse SM and Ginsburg M . (1993). Trends Biochem. Sci., 18, 377–378.

  • Kotani S, Tugendreich S, Fujii M, Jorgensen PM and Watanabe N . (1998). Mol. Cell, 1, 371–380.

  • Kumagai A and Dunphy WG . (1992). Cell, 70, 139–151.

  • Kumagai A and Dunphy WG . (1996). Science, 273, 1377–1380.

  • Lammer C, Wagerer S, Saffrich R, Mertens D, Ansorge W and Hoffmann I . (1998). J. Cell Sci., 111, 2445–2453.

  • Lane HA and Nigg EA . (1996). J. Cell Biol., 135, 1701–1713.

  • Leung GC, Hudson JW, Kozarova A, Davidson A, Dennis JW and Sicheri F . (2002). Nat. Struct. Biol., 9, 719–724.

  • Li B, Ouyang B, Pan H, Reissmann PT, Slamon DJ, Arceci R, Lu L and Dai W . (1996). J. Biol. Chem., 271, 19402–19408.

  • Liu F, Stanton JJ, Wu Z and Piwnica-Worms H . (1997). Mol. Cell. Biol., 17, 571–583.

  • Llamazares S, Moreira A, Tavares A, Girdham C, Spruce BA, Gonzalez C, Karess RE, Glover DM and Sunkel CE . (1991). Genes Dev., 5, 2153–2165.

  • Losada A, Hirano M and Hirano T . (2002). Genes Dev., 16, 3004–3016.

  • Ma S, Liu M-Y, Yuan Y-LO and Erikson RL . (2003). Mol. Cancer Res., 1, 376–384.

  • Mailand N, Falck J, Lukas C, Syljuasen RG, Welcker M, Bartek J and Lukas J . (2000). Science, 288, 1425–1429.

  • Mailand N, Podtelejnikov AV, Groth A, Mann M, Bartek J and Lukas J . (2002). EMBO J., 21, 5911–5920.

  • Margolis SS, Walsh S, Weiser DC, Yoshida M, Shenolikar S and Kornbluth S . (2003). EMBO J., 22, 5734–5745.

  • McGowan CH and Russell P . (1993). EMBO J., 12, 75–85.

  • Morgan DO . (1995). Nature, 374, 131–134.

  • Mueller PR, Coleman TR, Kumagai A and Dunphy WG . (1995). Science, 270, 86–90.

  • Nigg EA . (1993). Curr. Opin. Cell Bio., 5, 187–193.

  • Nigg EA . (1995). Bioassays, 17, 471–481.

  • Nigg EA . (1998). Curr. Opin. Cell Biol., 10, 776–783.

  • Nurse P, Masui Y and Hartwell L . (1998). Nat. Med., 4, 1103–1106.

  • Nurse P . (1975). Nature, 256, 547–551.

  • Ohkura H, Hagan IM and Glover DM . (1995). Genes Dev., 9, 1059–1073.

  • Okano-Uchida T, Okumura E, Iwashita M, Yoshida H, Tachibana K and Kishimoto T . (2003). EMBO J., 22, 5633–5642.

  • Ouyang B, Li W, Pan H, Meadows J, Hoffmann I and Dai W . (1999). Oncogene, 18, 6029–6036.

  • Ouyang B, Pan H, Lu L, Li J, Stambrook P, Li B and Dai W . (1997). J. Biol. Chem., 272, 28646–28651.

  • Peng CY, Graves PR, Thoma RS, Wu Z, Shaw AS and Piwnica-Worms H . (1997). Science, 277, 1501–1505.

  • Poon RY, Yamashita K, Adamczewski JP, Hunt T and Shuttleworth J . (1993). EMBO J., 12, 3123–3132.

  • Qian YW, Erikson E, Li C and Maller JL . (1998). Mol. Cell. Biol., 18, 4262–4271.

  • Reynolds RA, Yem AW, Wolfe CL, Deibel Jr MR, Chidester CG and Watenpaugh KD . (1999). J. Mol. Biol., 293, 559–568.

  • Roshak AK, Capper EA, Imburgia C, Fornwald J, Scott G and Marshall LA . (2000). Cell Signal., 12, 405–411.

  • Ruan Q, Wang Q, Xie S, Fang Y, Darzynkiewicz Z, Guan K, Jhanwar-Uniyal M and Dai W . (2004). Exp. Cell Res., 294, 51–59.

  • Russell P and Nurse P . (1987). Cell, 49, 559–567.

  • Shirayama M, Zachariae W, Ciosk R and Nasmyth K . (1998). EMBO J., 17, 1336–1349.

  • Simmons DL, Neel BG, Stevens R, Evett G and Erikson RL . (1992). Mol. Cell. Biol., 12, 4164–4169.

  • Solomon MJ, Harper JW and Shuttleworth J . (1993). EMBO J., 12, 3133–3142.

  • Song S and Lee KS . (2001). J. Cell Biol., 152, 451–469.

  • Stukenberg PT and Kirschner MW . (2001). Mol. Cell., 7, 1071–1083.

  • Sutterlin C, Lin CY, Feng Y, Ferris DK, Erikson RL and Malhotra V . (2001). Proc. Natl. Acad. Sci. USA, 98, 9128–9132.

  • Toyoshima-Morimoto F, Taniguchi E and Nishida E . (2002). EMBO J., 3, 341–348.

  • Toyoshima-Morimoto F, Taniguchi E, Shinya N, Iwamatsu A and Nishida E . (2001). Nature, 410, 215–220.

  • Vigo E, Muller H, Prosperini E, Hateboer G, Cartwright P, Moroni MC and Helin K . (1999). Mol. Cell. Biol., 19, 6379–6395.

  • Wang Q, Xie S, Chen J, Fukasawa K, Naik U, Traganos F, Darzynkiewicz Z, Jhanwar-Uniyal M and Dai W . (2002). Mol. Cell. Biol., 22, 3450–3459.

  • Wilborn M, Free S, Ban A and Rudolph J . (2001). Biochemistry, 40, 14200–14206.

  • Xie S, Wang Q, Ruan Q, Liu T, Jhanwar-Uniyal M, Guan K and Dai W . (2004). Oncogene, 23, 3822–3829.

  • Zhou BB and Elledge SJ . (2000). Nature, 408, 433–439.

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Acknowledgements

We apologize to the many authors whose original work could not be cited owing to space limitations. We are grateful to the National Institutes of Health, NIH Grants, R01 CA90934, UO1 ES011038, and P30 ES05652 and The Center for Environmental Genetics at the University of Cincinnati (CEG Center Grant P30-ES06096) for research support. DM was a trainee on NIH training grant T32 ES07250.

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Correspondence to Peter J Stambrook.

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Myer, D., Bahassi, E. & Stambrook, P. The Plk3-Cdc25 circuit. Oncogene 24, 299–305 (2005). https://doi.org/10.1038/sj.onc.1208278

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