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  • Original Paper
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Selectively frequent expression of CXCR5 enhances resistance to apoptosis in CD8+CD34+ T cells from patients with T-cell-lineage acute lymphocytic leukemia

Oncogene volume 24, pages 573–584 (2005)Cite this article

A Retraction to this article was published on 16 June 2011

Abstract

We investigated CD4+CD34+, CD8+CD34+, CD4+CD34−, and CD8+CD34− T cells from cord blood and from typical patients with T-cell-lineage acute lymphocytic leukemia and T-cell-lineage chronic lymphocytic leukemia in terms of expression and functions of CXCR5/CXCL13. We found that CXCR5 was selectively frequently expressed on T-cell-lineage acute (chronic) lymphocytic leukemia (T-ALL) CD8+CD34+ T cells, but not on T-ALL CD4+CD34+, CD4+CD34−, and CD8+CD34− T cells. CXCR5 was rarely expressed on all types of CD34+ and CD34− CB or T-CLL T cells. CXCL13/B cells attracting chemokine 1 induced significant resistance to TNF-α-mediated apoptosis in T-ALL CD8+CD34+ T cells, instead of induction of chemotactic and adhesive responsiveness. A proliferation-inducing ligand expression in T-ALL CD8+CD34+ T cells was upregulated by CXCL13/BCA-1 (B-cell attracting chemokine 1). The CXCR5/CXCL13 pair by means of activation of APRIL (A proliferation-inducing ligand) induced resistance to apoptosis in T-ALL CD8+CD34+ T cells in livin-dependent manner. In this process, cell–cell contact in culture was necessary. Based on our findings, we suggested that there were differential functions of CXCR5/CXCL13 in distinct types of cells. Normal lymphocytes, especially naïve B and T cells, utilized CXCR5/CXCL13 for migration, homing, maturation, and cell homeostasis, as well as secondary lymphoid tissue organogenesis. Meanwhile, certain malignant cells took advantages of CXCR5/CXCL13 for infiltration, resistance to apoptosis, and inappropriate proliferation.

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Abbreviations

APRIL:

A proliferation-inducing ligand

BCA-1:

B-cell attracting chemokine 1

BCMA:

B-cell maturation antigen

C.I.:

chemotactic index

CXCL (CC):

CXC (CC) chemokine ligand

CXCR (CC):

CXC (CC) chemokine receptor

T-ALL (T-CLL):

T-cell-lineage acute (chronic) lymphocytic leukemia

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Acknowledgements

This work was supported by the National Science Foundation of China (no. 39870674), Science Foundation of Anhui Province, China (no. 98436630), and Education and Research Foundation of Anhui Province, China (no. 98JL063), and Research Foundation from Health Department of Hubei Provincial Gvernment, China (no. 301140344).

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Author notes

  1. Zhang Qiuping and Xiong Jie: These authors contributed equally to this work

Authors and Affiliations

  1. Laboratory of Allergy and Clinical Immunology, Department of Immunology, Institute of Allergy and Immune-related Diseases, Centre for Medical Research, Wuhan University School of Medicine, Wuhan University, Dong Hu Road 115, Wuchang, Wuhan, 430071, China

    Zhang Qiuping, Xiong Jie, Wu Qun, Ju Wei, Liu Chun, Wang Jin, Liu Yan, Liu Junyan & Tan Jinquan

  2. The State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Science, Shanghai, China

    Xiong Jie & Jin Youxin

  3. Department of Immunology, College of Basic Medical Sciences, Anhui Medical University, Hefei, 230032, China

    Hu Chunsong, Li Qun & Tan Jinquan

  4. Department of Hematology, The Affiliated University Hospital, Anhui Medical University, Hefei, 230031, China

    Yang Mingzhen

  5. Department of Hematology, The First and Second Affiliated University Hospital, Wuhan University, Wuhan, 430071, China

    Gao Qingping & Zhang Kejian

  6. Department of Hematology, The Provincial Hospital of Anhui, Hefei, 230020, China

    Sun Zhimin

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Correspondence to Tan Jinquan.

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Qiuping, Z., Jie, X., Youxin, J. et al. Selectively frequent expression of CXCR5 enhances resistance to apoptosis in CD8+CD34+ T cells from patients with T-cell-lineage acute lymphocytic leukemia. Oncogene 24, 573–584 (2005). https://doi.org/10.1038/sj.onc.1208184

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