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  • Oncogenomics
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Expression profiling reveals a distinct transcription signature in follicular thyroid carcinomas with a PAX8-PPARγ fusion oncogene

Oncogene volume 24, pages 1467–1476 (2005)Cite this article

Abstract

The demonstration of the PAX8-PPARγ fusion oncogene in a subset of follicular thyroid tumors provides a new and promising starting point to dissect the molecular genetic events involved in the development of this tumor form. In the present study, we compared the gene expression profiles of follicular thyroid carcinomas (FTCs) bearing a PAX8-PPARγ fusion against FTCs that lack this fusion. Using unsupervised clustering and multidimensional scaling analyses, we show that FTCs possessing a PAX8-PPARγ fusion have a highly uniform and distinct gene expression signature that clearly distinguishes them from FTCs without the fusion. The PAX8-PPARγ(+) FTCs grouped in a defined cluster, where highly ranked genes were mostly associated with signal transduction, cell growth and translation control. Notably, a large number of ribosomal protein and translation-associated genes were concurrently underexpressed in the FTCs with the fusion. Taken together, our findings further support that follicular carcinomas with a PAX8-PPARγ rearrangement constitute a distinct biological entity. The current data represent one step to elucidate the molecular pathways in the development of FTCs with the specific PAX8-PPARγ fusion.

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Acknowledgements

This work was financially supported by the Swedish Cancer Society, the Vera and Emil Cornell Foundation, the Robert Lundberg Foundation, the Åke Wiberg Foundation, the Nilsson-Ehle Foundation, the Cancer Society in Stockholm and the Stockholm County Council. WOL is a recipient of a fellowship from the Swedish Society for Medical Research.

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Author notes

  1. Weng-Onn Lui

    Present address: Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Lane Building, L313, Stanford, CA, 94305-5324, USA

Authors and Affiliations

  1. Department of Molecular Medicine, Karolinska University Hospital, Solna, CMM L8:01, SE-171 76, Stockholm, Sweden

    Weng-Onn Lui, Theodoros Foukakis, Srinivasan R Thoppe, Trisha Dwight & Catharina Larsson

  2. Center for Surgical Sciences, Karolinska University Hospital, Huddinge, K54, SE-141 86, Huddinge, Sweden

    Theodoros Foukakis, Trisha Dwight & Jan Zedenius

  3. Department of Surgical Sciences, Karolinska University Hospital, Solna, P9:03, SE-171 76, Stockholm, Sweden

    Theodoros Foukakis & Göran Wallin

  4. Department of Biosciences, NOVUM, SE-141 57, Huddinge, Sweden

    Johan Lidén

  5. Department of Oncology-Pathology, Karolinska University Hospital, Solna, P1:02, SE-171 76, Stockholm, Sweden

    Anders Höög

  6. Laboratory of Molecular Pharmacology, National Cancer Institute, Bethesda, MD, 20892, USA

    Mark Reimers

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Correspondence to Weng-Onn Lui.

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Supplementary Information accompanies the paper on Oncogene website (http://www.nature.com/onc).

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Lui, WO., Foukakis, T., Lidén, J. et al. Expression profiling reveals a distinct transcription signature in follicular thyroid carcinomas with a PAX8-PPARγ fusion oncogene. Oncogene 24, 1467–1476 (2005). https://doi.org/10.1038/sj.onc.1208135

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