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Core-binding factors in hematopoiesis and immune function

Oncogene volume 23, pages 4238–4248 (2004)Cite this article

Abstract

Core binding factors are heterodimeric transcription factors containing a DNA binding Runx1, Runx2, or Runx3 subunit, along with a non DNA binding CBFβ subunit. All four subunits are required at one or more stages of hematopoiesis. This review describes the role of Runx1 and CBFβ in the initiation of hematopoiesis in the embryo, and in the emergence of hematopoietic stem cells. We also discuss the later stages of hematopoiesis for which members of the core binding factor family are required, as well as the recently described roles for these proteins in autoimmunity.

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References

  • Agata Y, Kawasaki A, Nishimura H, Ishida Y, Tsubata T, Yagita H and Honjo T . (1996). Int. Immunol., 8, 765–772.

  • Amann JM, Nip J, Strom DK, Lutterbach B, Harada H, Lenny N, Downing JR, Meyers S and Hiebert SW . (2001). Mol. Cell. Biol., 21, 6470–6483.

  • Bae SC, Yamaguchi-Iwai Y, Ogawa E, Maruyama M, Inuzuka M, Kagoshima H, Shigesada K, Satake M and Ito Y . (1993). Oncogene, 8, 809–814.

  • Basecke J, Feuring-Buske M, Brittinger G, Schaefer UW, Hiddeman W and Griesinger F . (2002). Ann. Hematol., 81, 254–257.

  • Berger R, Bernheim A, Daniel MT, Valensi F, Sigaux F and Flandrin G . (1982). Blood, 59, 171–178.

  • Bjerregaard MD, Jurlander J, Klausen P, Borregaard N and Cowland JB . (2003). Blood, 101, 4322–4332.

  • Boral AL, Okenquist SA and Lenz J . (1989). J. Virol., 63, 76–84.

  • Burel SA, Harakawa N, Zhou L, Pabst T, Tenen DG and Zhang DE . (2001). Mol. Cell. Biol., 22, 144–146.

  • Burns CE, DeBlasio T, Zhou Y, Zhang J, Zon L and Nimer SD . (2002). Exp. Hematol., 30, 1381–1389.

  • Cai Z, de Bruijn MFTR, Ma X, Dortland B, Luteijn T, Downing JR and Dzierzak E . (2000). Immunity, 13, 423–431.

  • Castilla LH, Garrett L, Adya N, Orlic D, Dutra A, Anderson S, Owens J, Eckhaus M, Bodine D and Liu PP . (1999). Nat. Genet., 23, 144–146.

  • Castilla LH, Wijmenga C, Wang Q, Stacy T, Speck NA, Eckhaus M, Marín-Padilla M, Collins FS, Wynshaw-Boris A and Liu PP . (1996). Cell, 87, 687–696.

  • Chimienti G, Alaibac M, Marzullo F, Carbone A and Pepe G . (2000). Blood Cells Mol. Dis., 26, 186–192.

  • Choi K, Kennedy M, Kazarov A, Papadimitriou JC and Keller G . (1998). Development, 125, 725–732.

  • Chung YS, Zhang WJ, Arentson E, Kingsley PD, Palis J and Choi K . (2002). Development, 129, 5511–5520.

  • Ciau-Uitz A, Walmsley M and Patient R . (2000). Cell, 102, 787–796.

  • Curtis DJ, Hall MA, Van Stekelenburg LJ, Robb L, Jane SM and Begley CG . (2004). Blood, January 15 [Epub ahead of print].

  • de Bruijn MFTR, Speck NA, Peeters MCE and Dzierzak E . (2000). EMBO J., 19, 2465–2474.

  • de Guzman CG, Warren AJ, Zhang Z, Gartland L, Erickson P, Drabkin H, Hiebert SW and Klug CA . (2002). Mol. Cell. Biol., 2002, 5506–5517.

  • Dowton SB, Beardsley D, Jamison D, Blattner S and Li FP . (1985). Blood, 65, 557–563.

  • Dzierzak E, Medvinsky A and de Bruijn M . (1998). Immunol. Today, 19, 228–236.

  • Ehlers M, Laule-Kilian K, Petter M, Aldrian CJ, Grueter B, Wurch A, Yoshida N, Watanabe T, Satake M and Steimle V . (2003). J. Immunol., 171, 3594–3604.

  • Elagib KE, Racke FK, Mogass M, Khetawat R, Delehanty LL and Goldfarb AN . (2003). Blood, 101, 4333–4341.

  • Elefanty AG, Begley CG, Hartley L, Papaevangeliou B and Robb L . (1999). Blood, 94, 3754–3763.

  • Fainaru O, Woolf E, Lotem J, Yarmus M, Brenner O, Goldenberg D, Negreanu V, Bernstein Y, Levanon D, Jung S and Groner Y . (2004). EMBO J., 23, 969–979.

  • Fraser ST, Ogawa M, Yokomizo T, Ito Y and Nishikawa S . (2003). Dev. Growth Differ., 45, 63–75.

  • Fujimoto T, Ogawa M, Minegishi N, Yoshida H, Yokomizo T, Yamamoto M and Nishikawa S . (2001). Genes Cells, 6, 1113–1127.

  • Gerrard JM, Israels ED, Bishop AJ, Schroeder ML, Beattie LL, McNicol A, Israels SJ, Walz D, Greenberg AH and Ray M et al. (1991). Br. J. Haematol., 79, 246–255.

  • Giese K, Kingsley C, Kirshner JR and Grosschedl R . (1995). Genes. Dev., 9, 995–1008.

  • Gill J, Malin M, Sutherland J, Gray D, Hollander G and Boyd R . (2003). Immunol. Rev., 195, 28–50.

  • Godin I and Cumano A . (2002). Nat. Rev. Immunol., 2, 593–604.

  • Gottgens B, Broccardo C, Sanchez MJ, Deveaux S, Murphy G, Gothert JR, Kotsopoulou E, Kinston S, Delaney L, Piltz S, Barton LM, Knezevic K, Erber WN, Begley CG, Frampton J and Green AR . (2004). Mol. Cell. Biol., 24, 1870–1883.

  • Hall MA, Curtis DJ, Metcalf D, Elefanty AG, Sourris K, Robb L, Gothert JR, Jane SM and Begley CG . (2003). Proc. Natl. Acad. Sci. USA, 100, 992–997.

  • Hallberg B, Thornell A, Holm M and Grundstrom T . (1992). Nucleic Acids Res., 20, 6495–6499.

  • Hayashi K, Abe N, Watanabe T, Obinata M, Ito M, Sato T, Habu S and Satake M . (2001). J. Immunol., 167, 4957–4965.

  • Hayashi K, Natsume W, Watanabe T, Abe N, Iwai M, Okada H, Ito Y, Asano M, Iwakura Y, Habu S, Takahama Y and Satake M . (2000). J. Immunol., 165, 6816–6824.

  • Helms C, Cao L, Krueger JG, Wijsman EM, Chamian F, Gordon D, Heffernan M, Daw JA, Robarge J, Ott J, Kwok PY, Menter A and Bowcock AM . (2003). Nat. Genet., 35, 349–356.

  • Hiebert SW, Sun W, Davis N, Golub T, Shurtleff S, Buijs A, Downing JR, Grosveld G, Roussel MF, Gilliland DG, Lenny N and Meyers S . (1996). Mol. Cell. Biol., 16, 1349–1355.

  • Higuchi M, O’Brien D, Kumaravelu P, Lenny N, Yeoh EH and Downing JR . (2002). Cancer Cell, 1, 63–74.

  • Hsiang YH, Spencer D, Wang S, Speck NA and Raulet DH . (1993). J. Immunol., 150, 3905–3916.

  • Huang G, Shigesada K, Ito K, Wee HJ, Yokomizo T and Ito Y . (2001). EMBO J., 15, 723–733.

  • Hug BA, Lee SY, Kinsler EL, Zhang J and Lazar MA . (2002). Cancer Res., 62, 2906–2912.

  • Ichikawa M, Asai T, Saito T, Yamamoto G, Seo S, Yamazaki I, Yamagata T, Mitani K, Chiba S, Hirai H, Ogawa S and Kurokawa M . (2004). Nat. Med., 10, 299–304.

  • Imai Y, Kurokawa M, Tanaka K, Friedman AD, Ogawa S, Mitani K, Yazaki Y and Hirai H . (1998). Biochem. Biophys. Res. Commun., 252, 582–589.

  • Itoh K, Sakakibara M, Yamasaki S, Takeuchi A, Arase H, Miyazaki M, Nakajima N, Okada M and Saito T . (2002). J. Immunol., 168, 541–544.

  • Jaffredo T, Gautier R, Brajeul V and Dieterlen-Lièvre F . (2000). Dev. Biol., 224, 204–214.

  • Jaffredo T, Gautier R, Eichmann A and Dieterlen-Lièvre F . (1998). Development, 125, 4575–4583.

  • Kalev-Zhylinska M, Horsfield JA, Flores MVC, Postlethwait JH, Vitas MR, Baas AM, Crosier PS and Crosier KE . (2002). Development, 129, 2015–2030.

  • Kataoka H, Ochi M, Enomoto K and Yamuguchi A . (2000). Mech. Dev., 98, 139–143.

  • Kohzaki H, Ito K, Huang G, Wee HJ, Murakami Y and Ito Y . (1999). Oncogene, 18, 4055–4062.

  • Komine O, Hayashi K, Natsume W, Watanabe T, Seki Y, Seki N, Yagi R, Sukzuki W, Tamauchi H, Hozumi K, Habu S, Kubo M and Satake M . (2003). J. Exp. Med., 198, 51–61.

  • Komori T, Yagi H, Nomura S, Yamaguchi A, Sasaki K, Deguchi K, Shimizu Y, Bronson RT, Gao Y-H, Inada M, Sato M, Okamoto R, Kitamura Y, Yoshiki S and Kishimoto T . (1997). Cell, 89, 755–764.

  • Kundu M, Chen A, Anderson S, Kirby M, Xu L, Castilla L, Bodine DM and Lui PP . (2002). Blood, 100, 2449–2456.

  • Lacaud G, Gore L, Kennedy M, Kouskoff V, Kingsley P, Hogan C, Carlsson L, Speck N, Palis J and Keller G . (2002). Blood, 100, 458–466.

  • Lauzurica P, Zhong X-P, Krangel MS and Roberts JL . (1997). J. Exp. Med., 185, 1193–1201.

  • Le XF, Groner Y, Kornblau SM, Gu Y, Hittelman WN, Levanon D, Mehta K, Arlinghaus RB and Chang KS . (1999). J. Biol. Chem., 274, 21651–21658.

  • Levanon D, Bernstein Y, Negreanu V, Ghozi MC, Bar-Am I, Aloya R, Goldenberg D, Lotem J and Groner Y . (1996). DNA Cell Biol., 15, 175–185.

  • Levanon D, Bettoun D, Harris-Cerruti C, Woolf E, Negreanu V, Eilam R, Bernstein Y, Goldenberg D, Xiao C, Fliegauf M, Kremer E, Otto F, Brenner O, Lev-Tov A and Groner Y . (2002). EMBO J., 21, 3454–3456.

  • Levanon D, Brenner O, Negreanu V, Bettoun D, Woolf E, Eilam R, Lotem J, Gat U, Speck N and Groner Y . (2001a). Mech. Dev., 109, 413–417.

  • Levanon D, Glusman G, Bangsow T, Ben-Asher E, Male DA, Avidan N, Bangsow C, Hattori M, Taylor TD, Taudien S, Blechschmidt K, Shimizu N, Rosenthal A, Sakaki Y, Lancet D and Groner Y . (2001b). Gene, 262, 23–33.

  • Levanon D, Goldstein RE, Bernstein Y, Tang H, Goldenberg D, Stifani S, Paroush Z and Groner Y . (1998). Proc. Natl. Acad. Sci. USA, 95, 11590–11595.

  • Lewis AF, Stacy T, Green W, Taddesse-Heath L, Hartley JW and Speck NA . (1999). J. Virol., 73, 5535–5547.

  • Li Q-L, Ito K, Sakakura C, Fukamachi H, Inoue K, Chi X-Z, Lee K-Y, Nomura S, Lee C-W, Han S-B, Kim H-M, Kim W-J, Yamamoto H, Yamashita N, Yano T, Ikeda T, Itohara S, Inazawa J, Abe T, Hagiwara A, Yamagishi H, Ooe A, Kaneda A, Sugimura T, Ushijima T, Bae S-C and Ito Y . (2002). Cell, 109, 113–124.

  • Lind EF, Prockop SE, Porritt HE and Petrie HT . (2001). J. Exp. Med., 194, 127–134.

  • Liu P, Tarle SA, Hajra A, Claxton DF, Marlton P, Freedman M, Siciliano MJ and Collins FS . (1993). Science, 261, 1041–1044.

  • Lorsbach RB, Moore J, Ang SO, Sun W, Lenny N and Downing JR . (2004). Blood, 103, 2522–2529.

  • Luddy RE, Champion LA and Schwartz AD . (1978). Cancer, 41, 1959–1963.

  • Medvinsky AL, Gan OI, Semenova ML and Samoylina NL . (1996). Blood, 87, 557–566.

  • Meyers S, Lenny N and Hiebert SW . (1995). Mol. Cell. Biol., 15, 1974–1982.

  • Meyers S, Lenny N, Sun W and Hiebert SW . (1996). Oncogene, 13, 303–312.

  • Mikkola HK, Klintman J, Yang H, Hock H, Schlaeger TM, Fujiwara Y and Orkin SH . (2003). Nature, 421, 547–551.

  • Miller J, Horner A, Stacy T, Lowrey C, Lian JB, Stein G, Nuckolls GH and Speck NA . (2002). Nat. Genet., 32, 645–649.

  • Miyoshi H, Ohira M, Shimizu K, Mitani K, Hirai H, Imai T, Yokoyama K, Soeda E and Ohki M . (1995). Nucleic Acids Res., 23, 2762–2769.

  • Miyoshi H, Shimizu K, Kozu T, Maseki N, Kaneko Y and Ohki M . (1991). Proc. Natl. Acad. Sci. USA, 88, 10431–10434.

  • Mombaerts P, Iacomini J, Johnson RS, Herrup K, Tonegawa S and Papaioannou VE . (1992). Cell, 68, 869–877.

  • Mukouyama Y, Chiba N, Hara T, Okada H, Ito Y, Kanamuru R, Miyajima A, Satake M and Watanabe T . (2000). Dev. Biol., 220, 27–36.

  • Niki M, Okada H, Takano H, Kuno J, Tani K, Hibino H, Asano S, Ito Y, Satake M and Noda T . (1997). Proc. Natl. Acad. Sci. USA, 94, 5697–5702.

  • Nishikawa S-I, Nishikawa S, Hirashima M, Matsuyoshi N and Kodama H . (1998a). Development, 125, 1747–1757.

  • Nishikawa S-I, Nishikawa S, Kawamoto H, Yoshida H, Kizumoto M, Kataoka H and Katsura Y . (1998b). Immunity, 8, 761–769.

  • Nishimura H, Nose M, Hiai H, Minato N and Honjo T . (1999). Immunity, 11, 141–151.

  • Nishimura M, Fukushima-Nakase Y, Fujita Y, Nakao M, Toda S, Kitamura N, Abe T and Okuda T . (2004). Blood, 103, 562–570.

  • North TE, de Bruijn MFTR, Stacy TS, Talebian L, Lind E, Robin C, Binder M, Dzierzak E and Speck NA . (2002). Immunity, 16, 661–672.

  • North TE, Gu T-L, Stacy T, Wang Q, Howard L, Binder M, Marín-Padilla M and Speck NA . (1999). Development, 126, 2563–2575.

  • North TE, Stacy T, Matheny CJ, Speck NA and De Bruijn MF . (2004). Stem Cells, 22, 158–168.

  • Oberlin E, Tavian M, Blazsek I and Peault B . (2002). Development, 129, 4147–4157.

  • Okazaki T, Maeda A, Nishimura H, Kurosaki T and Honjo T . (2001). Proc. Natl. Acad. Sci. USA, 98, 13866–13871.

  • Okuda T, Cai Z, Yang S, Lenny N, Lyu C, van Deursen JMA, Harada H and Downing JR . (1998). Blood, 91, 3134–3143.

  • Okuda T, van Deursen J, Hiebert SW, Grosveld G and Downing JR . (1996). Cell, 84, 321–330.

  • Otto F, Thornell AP and Crompton T . (1997). Cell, 89, 765–772.

  • Pozner A, Goldenberg D, Negreanu V, Le SY, Elroy-Stein O, Levanon D and Groner Y . (2000). Mol. Cell. Biol., 20, 2297–2307.

  • Prokunina L, Castillejo-Lopez C, Oberg F, Gunnarsson I, Berg L, Magnusson V, Brookes AJ, Tentler D, Kristjansdottir H, Grondal G, Bolstad AI, Svenungsson E, Lundberg I, Sturfelt G, Jonssen A, Truedsson L, Lima G, Alcocer-Varela J, Jonsson R, Gyllensten UB, Harley JB, Alarcon-Segovia D, Steinsson K and Alarcon-Riquelme ME . (2002). Nat. Genet., 32, 666–669.

  • Prosser HM, Wotton D, Gegonne A, Ghysdael J, Wang S, Speck NA and Owen MJ . (1992). Proc. Natl. Acad. Sci. USA, 89, 9934–9938.

  • Puig-Kroger A, Sanchez-Elsner T, Ruiz N, Andreu EJ, Prosper F, Jensen UB, Gil J, Erickson P, Drabkin H, Groner Y and Corbi AL . (2003). Blood, 102, 3252–3261.

  • Reczek D, Berryman M and Bretscher A . (1997). J. Cell Biol., 139, 169–179.

  • Sanchez M, Gottgens B, Sinclair AM, Stanley M, Begley CG, Hunter S and Green AR . (1999). Development, 126, 3891–3904.

  • Sasaki K, Yagi H, Bronson RT, Tominaga K, Matsunashi T, Deguchi K, Tani Y, Kishimoto T and Komori T . (1996). Proc. Natl. Acad. Sci. USA, 93, 12359–12363.

  • Satake M, Nomura S, Yamaguchi-Iwai Y, Takahama Y, Hashimoto Y, Niki M, Yukihiko K and Ito Y . (1995). Mol. Cell. Biol., 15, 1662–1670.

  • Sato T, Ito R, Nunomura S, Ohno S, Hayashi K, Satake M and Habu S . (2003). Immunol. Lett., 89, 39–46.

  • Shi M-J and Stavnezer J . (1998). J. Immunol., 161, 6751–6760.

  • Shinkai Y, Rathbun G, Lam KP, Oltz EM, Stewart V, Mendelsohn M, Charron J, Datta M, Young F, Stall AM and Alt FW . (1992). Cell, 68, 855–867.

  • Silver L and Palis J . (1997). Blood, 89, 1154–1164.

  • Sinclair AM, Gottgens B, Barton LM, Stanley ML, Pardanaud L, Klaine M, Gering M, Bahn S, Sanchez M, Bench AJ, Fordham JL, Bockamp E and Green AR . (1999). Dev. Biol., 209, 128–142.

  • Song W-J, Sullivan MG, Legare RD, Hutchings S, Tan X, Kufrin D, Ratajczak J, Resende IC, Haworth C, Hock R, Loh M, Felix C, Roy D-C, Busque L, Kurnit D, Willman C, Gewirtz AM, Speck NA, Bushweller JH, Li FP, Gardiner K, Poncz M, Maris JM and Gilliland DG . (1999). Nat. Genet., 23, 166–175.

  • Speck NA and Baltimore D . (1987). Mol. Cell. Biol., 7, 1101–1110.

  • Speck NA, Renjifo B, Golemis E, Fredrickson TN, Hartley JW and Hopkins N . (1990). Genes Dev., 4, 233–242.

  • Starr TK, Jameson SC and Hogquist KA . (2003). Annu. Rev. Immunol., 21, 139–176.

  • Swirsky DM, Li YS, Matthews JG, Flemans RJ, Rees JK and Hayhoe FG . (1984). Br. J. Haematol., 56, 199–213.

  • Sykes DB and Kamps MP . (2001). Blood, 98, 2308–2318.

  • Tanaka T, Mitani K, Kurokawa M, Ogawa S, Tanaka K, Nishida J, Yazaki Y, Shibata Y and Hirai H . (1995). Mol. Cell. Biol., 15, 2383–2392.

  • Taniuchi I, Osato M, Egawa T, Sunshine MJ, Bae S-C, Komori T, Ito Y and Littman DR . (2002). Cell, 111, 621–633.

  • Telfer JC, Hedblom EE, Anderson MK, Laurent MN and Rothenberg EV . (2004). J. Immunol., 172, 4359–4370.

  • Telfer JC and Rothenberg EV . (2001). Dev. Biol., 229, 363–382.

  • Thornell A, Hallberg B and Grundstrom T . (1988). Mol. Cell. Biol., 8, 1625–1637.

  • Tokuhiro S, Yamada R, Chang X, Suzuki A, Kochi Y, Sawada T, Suzuki M, Nagasaki M, Ohtsuki M, Ono M, Furukawa H, Nagashima M, Yoshino S, Mabuchi A, Sekine A, Saito S, Takahashi A, Tsunoda T, Nakamura Y and Yamamoto K . (2003). Nat. Genet., 35, 341–348.

  • Tracey WD, Pepling ME, Horb ME, Thomsen GH and Gergen JP . (1998). Development, 125, 1371–1380.

  • Vaillant F, Blyth K, Terry A, Bell M, Cameron ER, Neil J and Stewart M . (1999). Oncogene, 18, 7124–7134.

  • Wang Q, Stacy T, Binder M, Marín-Padilla M, Sharpe AH and Speck NA . (1996a). Proc. Natl. Acad. Sci. USA, 93, 3444–3449.

  • Wang Q, Stacy T, Miller JD, Lewis AF, Huang X, Bories J-C, Bushweller JH, Alt FW, Binder M, Marín-Padilla M, Sharpe A and Speck NA . (1996b). Cell, 87, 697–708.

  • Woolf E, Xiao C, Fainaru O, Lotem J, Rosen D, Negreanu V, Bernstein Y, Goldenberg D, Brenner O, Berke G, Levanon D and Groner Y . (2003). Proc. Natl. Acad. Sci. USA, 100, 7731–7736.

  • Yannoutsos N, Barreto V, Misulovin Z, Gazumyan A, Yu W, Rajewsky N, Peixoto BR, Eisenreich T and Nussenzweig MC . (2004). Nat. Immunol., 5, 443–450.

  • Yano M, Iwama A, Nishio H, Suda J, Takada G and Suda T . (1997). Blood, 89, 4317–4326.

  • Yokomizo T, Ogawa M, Osato M, Kanno T, Yoshida H, Fujimoto T, Fraser S, Nishikawa S, Okada H, Satake M, Noda T, Nishikawa SI and Ito Y . (2001). Genes Cells, 6, 13–23.

  • Yokomizo T, Osato M, Takahashi S, Kuroha T, Yamamoto M and Ito Y . (2000). Blood, 96, 283a.

  • Yuan Y, Zhou L, Miyamoto T, Iwasaki H, Harakawa N, Hetherington CJ, Burel SA, Lagasse E, Weissman IL, Akashi K and Zhang DE . (2001). Proc. Natl. Acad. Sci. USA, 98, 10398–10403.

  • Zent CS, Mathieu C, Claxton DF, Zhang DE, Tenen DG, Rowley JD and Nucifora G . (1996). Proc. Natl. Acad. Sci. USA, 93, 1044–1048.

  • Zhao FQ, Sheng ZM, Tsai MM, Hubbs AE, Wang R, O’Leary TJ, Izon DJ and Taubenberger JK . (2002). Int. Immunol., 14, 1383–1395.

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Acknowledgements

We thank Terryl Stacy for critically reading the manuscript, and Ellen Rothenberg and Rudi Hendriks for their helpful comments. We dedicate this article to the late Hisamaru Hirai, whose outstanding contribution to the study of Runx1 function in adult hematopoiesis both inspired and provided the focal point for this review.

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  1. MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, OX3 9DS, UK

    Marella FTR de Bruijn

  2. Department of Biochemistry, Dartmouth Medical School, Hanover, 03755, NH, USA

    Nancy A Speck

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de Bruijn, M., Speck, N. Core-binding factors in hematopoiesis and immune function. Oncogene 23, 4238–4248 (2004). https://doi.org/10.1038/sj.onc.1207763

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