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PRDM5 is silenced in human cancers and has growth suppressive activities

Oncogene volume 23, pages 4903–4910 (2004)Cite this article

Abstract

Several genes that contain the PR (PRDI-BF1 and RIZ) domain have been linked with human cancers. We describe here a new PR-domain-containing gene designated as PRDM5 (PFM2). A PRDM5 cDNA was isolated based on its homology to the PR domain of RIZ1 (PRDM2). The gene encodes an open reading frame of 630 amino acids and contains a PR domain in the NH-terminal region followed by 16 zinc finger motifs. Radiation hybrid analysis mapped PRDM5 to human chromosome 4q26, a region thought to harbor tumor suppressor genes for breast, ovarian, liver, lung, colon, and other cancers. The gene has a CpG island promoter and is silenced in human breast, ovarian, and liver cancers. A recombinant adenovirus expressing PRDM5 caused G2/M arrest and apoptosis upon infection of tumor cells. These results suggest that inactivation of PRDM5 may play a role in carcinogenesis.

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Acknowledgements

We thank Liqing Geng for technical assistance. This work was supported by grants from the NIH (RO1 CA76146) and the Cancer Research Program and the Breast Cancer Research Program of the University of California.

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  1. The Burnham Institute, 10901 N. Torrey Pines Road, La Jolla, 92037, CA, USA

    Qingdong Deng & Shi Huang

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  1. Qingdong Deng
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  2. Shi Huang
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Correspondence to Shi Huang.

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Deng, Q., Huang, S. PRDM5 is silenced in human cancers and has growth suppressive activities. Oncogene 23, 4903–4910 (2004). https://doi.org/10.1038/sj.onc.1207615

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