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Bcl-2 mediates induction of neural differentiation

Oncogene volume 22, pages 5515–5518 (2003)Cite this article

Abstract

Bcl-2 is an antiapoptotic protein expressed in a wide variety of cell types. We have found that overexpression of bcl-2 in PC12 neural crest tumor cells leads to increased expression of neural differentiation-associated genes and decreased expression of proliferation-related genes. Culture growth rate decreases as well. Overexpression of bcl-2 also leads to increased expression of TrkA and increased phosphorylation of signal transductants in, albeit not specific for, the TrkA–MEK–ERK pathway. Blocking of NGF-mediated signaling through TrkA prevents Bcl-2-associated expression changes in differentiation-associated genes, raising the possibility that Bcl-2 mediates induction of neural differentiation through TrkA/NGF signaling.

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Authors and Affiliations

  1. Pediatric Center for Neuroscience and Division of Child Neurology, University and Children's Hospital of Pittsburgh, Pittsburgh, PA, USA

    Ye Liang, Zeljka Korade Mirnics, Chaohua Yan, Karen D Nylander & Nina Felice Schor

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  1. Ye Liang
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  2. Zeljka Korade Mirnics
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  3. Chaohua Yan
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  4. Karen D Nylander
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  5. Nina Felice Schor
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Correspondence to Nina Felice Schor.

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Liang, Y., Mirnics, Z., Yan, C. et al. Bcl-2 mediates induction of neural differentiation. Oncogene 22, 5515–5518 (2003). https://doi.org/10.1038/sj.onc.1206844

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