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Molecular viral oncology of hepatocellular carcinoma

Oncogene volume 22, pages 5093–5107 (2003)Cite this article

Abstract

Hepatocellular carcinoma (HCC) is the fifth most common cancer, but the third leading cause of cancer death, in the world, with more than 500 000 fatalities annually. The major etiology of HCC/liver cancer in people is hepatitis B virus (HBV), followed by hepatitis C virus infection (HCV), although nonviral causes also play a role in a minority of cases. Recent molecular studies confirm what was suspected: that HCC tissue from different individuals have many phenotypic differences. However, there are clearly features that unify HCC occurring in a background of viral hepatitis B and C. HCC due to HBV and HCV may be an indirect result of enhanced hepatocyte turnover that occurs in an effort to replace infected cells that have been immunologically attacked. Viral functions may also play a more direct role in mediating oncogenesis. This review considers the molecular and cellular mechanisms involved in primary hepatocellular carcinoma, using a viral perspective.

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Acknowledgements

Preparation of this manuscript, and some of the work described herein, was supported by The Hepatitis B Foundation of America, The Early Detection Research Network of The National Cancer Institute (USA), and an appropriation from The Commonwealth of Pennsylvania.

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Authors and Affiliations

  1. Department of Molecular Pharmacology and Biochemistry, Jefferson Center for Biomedical Research of Thomas Jefferson University, 700 East Butler Ave., Doylestown, 18901, PA, USA

    Timothy M Block, Anand S Mehta, Claus J Fimmel & Robert Jordan

  2. Department of Internal Medicine, Division of Gastroenterology and Hepatology, St Louis University School of Medicine, St Louis, 63106, MO, USA

    Claus J Fimmel

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  1. Timothy M Block
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Correspondence to Timothy M Block.

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Block, T., Mehta, A., Fimmel, C. et al. Molecular viral oncology of hepatocellular carcinoma. Oncogene 22, 5093–5107 (2003). https://doi.org/10.1038/sj.onc.1206557

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