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Function and regulation of melanoma–stromal fibroblast interactions: when seeds meet soil

Oncogene volume 22, pages 3162–3171 (2003)Cite this article

Abstract

Melanoma development and progression not only involve genetic and epigenetic changes that take place within the melanocytic cells, but also involve processes that are determined collectively by contextual factors including intercellular adhesions and communications. In this review, we focus on melanoma–stromal fibroblast crosstalk by direct cell–cell contact and by growth factors/cytokines/chemokines interacting with their respective receptors. The interactions between melanoma cells and stromal fibroblasts create a context that promotes tumor growth, migration/invasion, and angiogenesis. An understanding of this process and developing new experimental and screening models are of great importance for the development of effective therapeutical strategies to treat melanoma.

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Acknowledgements

We thank all members of Herlyn lab for technical and intellectual support. We also thank Dr Dirk Ruiter for conceptual stimulation. We apologize to those whose seminal work is not directly cited owing, space constraints. This work was supported by National Institutes of Health Grants CA-25874, CA-76674, CA-47159, CA-80999, and CA-10815.

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  1. Kapaettu Satyamoorthy

    Present address: Center for Molecular and Cellular Biology, MAHE, Manipal, India

  2. Friedegund Meier

    Present address: Department of Dermatology, University of Tuebingen, Tuebingen, Germany

  3. Carola Berking

    Present address: Department of Dermatology, Ludwig-Maximilians-University Munich, Munich, Germany

Authors and Affiliations

  1. The Wistar Institute, 3601 Spruce Street, Philadelphia, 19104, PA, USA

    Gang Li, Kapaettu Satyamoorthy, Friedegund Meier, Carola Berking, Thomas Bogenrieder & Meenhard Herlyn

  2. Program of Cell and Molecular Biology, Biomedical Graduate Studies, University of Pennsylvania School of Medicine, Philadelphia, 19104, PA, USA

    Gang Li

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Li, G., Satyamoorthy, K., Meier, F. et al. Function and regulation of melanoma–stromal fibroblast interactions: when seeds meet soil. Oncogene 22, 3162–3171 (2003). https://doi.org/10.1038/sj.onc.1206455

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