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Oncogenes in melanoma

Oncogene volume 22, pages 3087–3091 (2003)Cite this article

Abstract

Transformation of normal melanocytes into melanoma cells is accomplished by the activation of growth stimulatory pathways, typically leading to cellular proliferation, and the inactivation of apoptotic and tumor suppressor pathways. Small molecule inhibitors of proteins in the growth stimulatory pathways are under active investigation, and their application to melanoma patients would represent a new treatement strategy to inhibit cell proliferation or induce cell death. We provide a general overview of the mechanisms of oncogene activation and the functions of oncogenes. Lastly, we review oncogenic events in melanoma.

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Authors and Affiliations

  1. Department of Dermatology, Oncology Section of the Skin and Cancer Unit, New York University Medical Center, 550 First Avenue, New York, 10016, NY, USA

    David Polsky

  2. Division of Molecular Pathology, Department of Pathology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, 10021, NY, USA

    Carlos Cordon-Cardo

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  1. David Polsky
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  2. Carlos Cordon-Cardo
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Correspondence to David Polsky.

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Polsky, D., Cordon-Cardo, C. Oncogenes in melanoma. Oncogene 22, 3087–3091 (2003). https://doi.org/10.1038/sj.onc.1206449

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