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  • Oncogenomics
  • Published:

Differential gene expression in distinct virologic types of hepatocellular carcinoma: association with liver cirrhosis

Abstract

Using oligonucleotide microarray data of 45 hepatocellular carcinoma (HCC) samples, we evaluated gene expression in hepatitis B virus-positive and hepatitis C virus-positive HCCs (HBV- and HCV-HCCs) for an association with liver cirrhosis (LC). In all, 89 genes were expressed differentially between HBV-HCCs associated with LC and those not associated with LC. Among them, tumors from LC patients showed significantly lower expression levels of 72 genes and significantly higher levels of 17 genes than the levels found in tumors from non-LC patients. The former included genes responsible for signal transduction, transcription, metabolism, and cell growth. The latter included a tumor suppressor gene and a cell-growth-related gene. Only eight genes were expressed differentially between HCV-HCCs associated with and without LC. Our findings provide as a framework for clarifying the role of LC in HBV- and HCV-related hepatocarcinogenesis.

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Abbreviations

HCC:

hepatocellular carcinoma

HBV:

hepatitis B virus

HCV:

hepatitis C virus

LC:

liver cirrhosis

HBX protein:

hepatitis B X protein

Gene abbreviations are used from Locus Link:

(http://www.ncbi.nlm.nih.gov/LocusLink/)

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Acknowledgements

This work was supported in part by a Grant-in-Aid from the Ministry of Education, Science, Sports and Culture of Japan (No. 12671230).

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Correspondence to Masaaki Oka.

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Iizuka, N., Oka, M., Yamada-Okabe, H. et al. Differential gene expression in distinct virologic types of hepatocellular carcinoma: association with liver cirrhosis. Oncogene 22, 3007–3014 (2003). https://doi.org/10.1038/sj.onc.1206401

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