Abstract
Ever since the discovery of Bcl-2 and the elucidation of its role in apoptosis, tremendous interest has arisen in prospects for triggering suicide of malignant cells by exploiting knowledge emerging from apoptosis research. In this review, we summarize information about the multiple genetic lesions which have been identified in apoptosis-regulatory genes of hematopoietic and lymphoid neoplasms. Emerging data about the structural and biochemical details of apoptosis proteins and their upstream regulators have reveal novel strategies for therapeutic intervention, some of which are under interrogation in clinical trials currently.
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References
Adams J, Palombella VJ, Elliott PJ . 2000 Invest. New Drugs 18: 109–121
Ahmed NN, Franke TF, Bellacosa A, Datta K, Gonzalez-Portal ME, Taguchi T, Testa JR, Tsichlis PN . 1993 Oncogene 8: 1957–1963
Altucci L, Rossin A, Raffelsberger W, Reitmair A, Chomienne C, Gronemeyer H . 2001 Nat. Med. 7: 680–686
Anthoney DA, McIlwrath AJ, Gallagher WM, Edlin AR, Brown R . 1996 Cancer Res. 56: 1374–1381
Ashkenazi A, Dixit V . 1998 Science 281: 1305–1308
Ashkenazi A, Dixit VM . 1999 Curr. Opin. Cell Biol 11: 255–260
Ashkenazi A, Pai RC, Fong S, Leung S, Lawrence DA, Marsters SA, Blackie C, Chang L, McMurtrey AE, Hebert A, DeForge L, Koumenis IL, Lewis D, Harris L, Bussiere J, Koeppen H, Shahrokh Z, Schwall RH . 1999 J. Clin. Invest. 104: 155–162
Bai RY, Ouyang T, Miething C, Morris SW, Peschel C, Duyster J . 2000 Blood 96: 4319–4327
Banker DE, Radich J, Becker A, Kerkof K, Norwood T, Willman C, Appelbaum FR . 1998 Clin. Cancer Res. 4: 3051–3062
Barkett M, Dooher JE, Lemonnier L, Simmons L, Scarpati JN, Wang Y, Gilmore TD . 2001 Biochim. Biophys. Acta 1526: 25–36
Belich MP, Salmeron A, Johnston LH, Ley SC . 1999 Nature 397: 363–368
Bergmann L, Miething C, Maurer U, Brieger J, Karakas T, Weidmann E, Hoelzer D . 1997 Blood 90: 1217–1225
Bladergroen BA, Strik MC, Bovenschen N, van Berkum O, Scheffer GL, Meijer CL, Hack CE, Kummer JA . 2001 J. Immunol. 166: 3218–3225
Borlado LR, Redondo C, Alvarez B, Jimenez C, Criado LM, Flores J, Marcos MA, Martinez AC, Balomenos D, Carrera AC . 2000 FASEB J. 14: 895–903
Boultwood J . 2001 J. Clin. Pathol. 54: 512–516
Brimmell M, Mendiola R, Mangion J, Packham G . 1998 Oncogene 16: 1803–1812
Britos-Bray M, Ramirez M, Cao W, Wang X, Liu PP, Civin CI, Friedman AD . 1998 Blood 92: 4344–4352
Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, Anderson MJ, Arden KC, Blenis J, Greenberg ME . 1999 Cell 96: 857–868
Cabannes E, Khan G, Aillet F, Jarrett RF, Hay RT . 1999 Oncogene 18: 3063–3070
Campos L, Roualult J-P, Sabido O, Roubi N, Vasselon C, Archimbaud E, Magaud J-P, Guyotat D . 1993 Blood 81: 3091–3096
Cardone M, Roy N, Stennicke H, Salvesen G, Franke T, Stanbridge E, Frisch S, Reed J . 1998 Science 282: 1318–1321
Chai J, Du C, Wu JW, Kyin S, Wang X, Shi Y . 2000 Nature 406: 855–862
Chang BS, Minn AJ, Muchmore SW, Fesik SW, Thompson CB . 1997 EMBO J. 16: 968–977
Cheng E, Clem R, Ravi R, Kirsch D, Kastan M, Bedi A, Ueno K, Hardwick J . 1997 Science 278: 1966–1968
Cheng J, Zhou T, Liu C, Shapiro JP, Brauer MJ, Kiefer MC, Barr PJ, Mountz JD . 1994 Science 263: 1759–1762
Cryns V, Yuan Y . 1999 Genes Dev. 12: 1551–1570
Dalton WS, Jove JR . 1999 Sem. Oncol. 26: 23–27
Datta S, Brunet A, Greenberg M . 1999 Genes Dev. 13: 2905–2927
de Groot RP, Raaijmakers JA, Lammers JW, Koenderman L . 2000 Mol. Cell. Biol. Res. Commun. 3: 299–305
Degterev A, Lugovskoy A, Cardone M, Mulley B, Wagner G, Mitchison T, Yuan J . 2001 Nature Cell Biol. 3: 173–182
Deveraux Q, Reed J . 1999 Genes Dev. 13: 239–252
Deveraux QL, Takahashi R, Salvesen GS, Reed JC . 1997 Nature 388: 300–304
Druker BJ, Sawyers CL, Kantarjian H, Resta DJ, Reese SF, Ford JM, Capdeville R, Talpaz M . 2001a N. Engl. J. Med. 344: 1038–1042
Druker BJ, Talpaz M, Resta DJ, Peng B, Buchdunger E, Ford JM, Lydon NB, Kantarjian H, Capdeville R, Ohno-Jones S, Sawyers CL . 2001b N. Engl. J. Med. 344: 1031–1037
Du C, Fang M, Li Y, Li L, Wang X . 2000 Cell 102: 33–42
Dyck J, Maul G, Miller W, Chen J, Kakizuka A, Evans R . 1994 Cell 76: 333–343
Emmerich F, Meiser M, Hummel M, Demel G, Foss HD, Jundt F, Mathas S, Krappmann D, Scheidereit C, Stein H, Dorken B . 1999 Blood 94: 3129–3134
Ergin M, Denning MF, Izban KF, Amin HM, Martinez RL, Saeed S, Alkan S . 2001 Exp. Haematol. 29: 1082–1090
Evan G, Littlewood T . 1998 Science 281: 1317–1322
Fang G, Kim CN, Perkins CL, Ramadevi N, Winton E, Wittmann S, Bhalla KN . 2000 Blood 96: 2246–2253
Fisher GH, Rosenberg FJ, Straus SE, Dale JK, Middelton LA, Lin AY, Strober W, Lenardo MJ, Puck JM . 1995 Cell 81: 935–946
Foster B, Coffey H, Morin M, Rastinejad F . 1999 Science 286: 2507–2510
Frisch SM, Ruoslahti E . 1997 Curr. Opin. Cell Biol 9: 701–706
Fu TB, Virgilio L, Narducci MG, Facchiano A, Russo G, Croce CM . 1994 Cancer Res. 54: 6297–6301
Gascoyne RD, Adomat SA, Krajewski S, Krajewska M, Horsman DE, Tolcher AM, O'Reilly SE, Coldman AJ, Reed JC, Connors JM . 1997 Blood 90: 244–251
Gauwerky CE, Hoxie J, Nowell PC, Croce CM . 1988 Oncogene 2: 431–435
Ge NL, Rudikoff S . 2000 Oncogene 19: 4091–4095
Gesbert FG . 2000 Blood 96: 2269–2276
Gil J, Yamamoto H, Zapata JM, Reed JC, Perucho M . 1999 Cancer Res. 59: 2034–2037
Gill S, Broni J, Jefferies S, Osin P, Kovacs G, Maitland NJ, Eeles R, Edwards SM, Dyer MJ, Willis TG, Cooper CS . 1999 Br. J. Cancer 80: 1565–1568
Gilmore TD . 1999 Oncogene 18: 6925–6937
Goke R, Goke A, Goke B, Chen Y . 2000 Cell Immunol. 201: 77–82
Graeber TG, Osmanian C, Jacks T, Housman DE, Koch CJ, Lowe SW, Giaccia AJ . 1996 Nature 379: 88–91
Graubert TA, DiPersio JP, Russell JH, Ley TJ . 1997 J. Clin. Invest. 100: 904–911
Green DR, Reed JC . 1998 Science 281: 1309–1312
Grignani F, Ferrucci PF, Testa U, Talamo G, Fagioli M, Alcalay M, Mencarelli A, Peschle C, Nicoletti I . 1993 Cell 74: 423–431
Grimwade D, Walker H, Oliver F, Wheatley K, Harrison C, Harrison G, Rees J, Hann I, Stevens R, Burnett A, Goldstone A . 1998 Blood 92: 2322–2333
Gronbaek K, Straten PT, Ralfkiaer E, Ahrenkiel V, Andersen MK, Hansen NE, Zeuthen J, Hou-Jensen K, Guldberg P . 1998 Blood 92: 3018–3024
Gross A, McDonnell J, Korsmeyer S . 1999 Genes Dev. 13: 1899–1911
Hague A, Diaz-Gómez G, Hicks D, Krajewski S, Reed J, Paraskeva C . 1997 Int. J. Cancer 72: 898–905
Hakem R, Hakem A, Duncan GS, Henderson JT, Woo M, Soengas MS, Elia A, de la Pompa JL, Kagi D, Khoo W, Potter J, Yoshida R, Kaufman SA, Lowe SW, Penninger JM, Mak TW . 1998 Cell 94: 339–352
Hay BA . 2000 Cell Death Differ. 7: 1045–1056
Heisterkamp N, Stam K, Groffen J, de Klein A, Grosveld G . 1985 Nature 315: 758–761
Hermine O, Haioun C, Lepage E, d'Agay M-F, Briere J, Lavignac C, Fillet G, Salles G, Marolleau J-P, Diebold J, Reyes F, Gaulard P . 1996 Blood 87: 265–272
Hess J, Korsmeyer S . 1998 Nat. Genet. 20: 220–222
Hewitt SM, Hamada S, McDonnell TJ, Rauscher FJ, Saunders GF . 1995 Cancer Res. 55: 5386–5389
Hill ME, MacLennan KA, Cunningham DC, Hudson BV, Burke M, Clarke P, DiStefano F, Anderson L, Hudson GV, Mason D, Selby P, Linch DC . 1996 Blood 88: 1046–1051
Hockenbery D, Nunez G, Milliman C, Schreiber R, Korsmeyer S . 1990 Nature 348: 334–336
Holmes-McNary M, Baldwin ASJ . 2000 Cancer Res. 60: 3477–3483
Houldsworth J, Mathew S, Rao PH, Dyomina K, Louie DC, Parsa N, Offit K, Chaganti RS . 1996 Blood 87: 25–29
Huang MT, Ho CT, Wang ZY, Ferraro T, Lou YR, Stauber K, Ma W, Georgiadis C, Laskin JD, Conney AH . 1994 Cancer Res. 54: 701–708
Inoue K, Kohno T, Takakura S, Hayashi Y, Mizoguchi H, Yokota J . 2000 Leuk. Res. 24: 255–262
Ito Y, Pandey P, Place A, Sporn MB, Gribble GW, Honda T, Kharbanda S, Kufe D . 2000 Cell Growth Differ. 11: 261–267
Itoh N, Yonehara S, Ishii A, Yonehara M, Mizushima S-I, Sameshima M, Hase A, Seto Y, Nagata S . 1991 Cell 66: 233–243
Joza N, Susin SA, Daugas E, Stanford WL, Cho SK, Li CY, Sasaki T, Elia AJ, Cheng H-YA, Ravagnan L, Ferri KF, Zamzami N, Wakeham A, Hakem R, Yoshida H, Kong Y-Y, Mak TW, Zúñiga-Pflücker JC, Kroemer G, Penninger JM . 2001 Nature 410: 549–554
Juo P, Kuo CJ, Yuan J, Blenis J . 1998 Curr. Biol. 8: 1001–1008
Kakizuka A, Miller W, Umesono K, Warrell R, Frankel S, Murty V, Dmitrovsky E, Evans R . 1991 Cell 66: 663–674
Kamihira S, Yamada Y, Tomonaga M, Sugahara K, Tsuruda K . 1999 Br. J. Haematol. 107: 851–860
Karanewsky DS, Bai X, Linton SD, Krebs JF, Wu J, Pham B, Tomaselli KJ . 1998 Bioorg. Med. Chem. Letters 8: 2757–2762
Karnolsky IN . 2000 Folia Medica (Plovdiv.) 42: 5–10
Kaufmann S, Brunet G, Talbot B, Lamarr D, Dumas C, Shaper J, Poirier G . 1991 Exp. Cell. Res. 192: 524–535
Kaufmann S, Karp J, Svingen P, Krajewski S, Burke P, Gore S, Reed J . 1998 Blood 91: 991–1000
Kitada S, Andersen J, Akar S, Zapata JM, Takayama S, Krajewski S, Wang H-G, Zhang X, Bullrich F, Croce CM, Rai K, Hines J, Reed JC . 1998 Blood 91: 3379–3389
Klampfer L, Zhang J, Zelenetz AO, Uchida H, Nimer SD . 1996 Proc. Natl. Acad. Sci. USA 93: 14059–14064
Komarov P, Komarova E, Kondratov R, Christov-Tselkov K, Coon J, Chernov M, Gudkov A . 1999 Science 285: 1733–1737
Kornblau SM, Vu HT, Ruvolo P, Estrov Z, O'Brien S, Cortes J, Kantarjian H, Andreeff M, May WS . 2000 Clin. Can. Res. 6: 1401–1409
Krammer PH . 2000 Nature 407: 789–795
Kuida K, Haydar TF, Kuan C-Y, Gu Y, Taya C, Karasuyama H, Su MS-S, Rakic P, Flavell RA . 1998 Cell 94: 325–337
Kupper M, Joos S, von Bonin F, Daus H, Pfreundschuh M, Lichter P, Trumper L . 2001 Br. J. Heamatol. 112: 768–775
Landowski TH, Wu N, Buyuksal I, Painter JS, Dalton WS . 1997 Blood 90: 4266–4270
Lee HH, Dadgostar H, Cheng Q, Shu J, Cheng G . 1999 Proc. Natl. Acad. Sci. USA 96: 9136–9141
Lengauer C, Kinzler K, Vogelstein B . 1998 Nature 396: 643–649
Li H, Zhu H, Xu C, Yuan J . 1998a Cell 94: 491–501
Li LY, Luo X, Wang X . 2001 Nature 412: 95–99
Li Y, Lin B, Agadir A, Liu R, Dawson MI, Reed JC, Fontana JA, Bost F, Hobbs PD, Zheng Y, Ghen G-Q, Shroot B, Mercola D, Zhang X-K . 1998b Mol. Cell. Biol 18: 4719–4731
Liu T-C, Lin P-M, Chang J-G, Lee J-P, Chen T-P, Sue Y-C, Lin S-F . 2000 Br. J. Haematol. 109: 250–252
Locksley RM, Killeen N, Lenardo MJ . 2001 Cell 102: 487–501
Look AT . 1997 Science 278: 1059–1064
Lowin B, Peitsch MC, Tschopp J . 1995 Curr. Top. Microbiol. Immunol. 198: 1–24
Luo X, Budihardjo I, Zou H, Slaughter C, Wang X . 1998 Cell 94: 481–490
Makin G, Hickmann JA . 2000 Cell Tissue Res. 301: 143–
Mancini M, Machamer CE, Roy S, Nicholson DW, Thornberry NA, Casciola-Rosen LA, Rosen A . 2000 J. Cell Biol. 149: 603–612
Mandal M, Kumar R . 1996 Cell Growth Differ. 7: 311–318
Masuyama N, Oishi K, Mori Y, Uneo T, Takahama Y, Gotoh Y . 2001 J. Biol. Chem. 276: 32799–32805
Mayo MW, Wang CY, Drouin SS, Madrid LV, Marshall AF, Reed JC, Weissman BE, Baldwin AS . 1999 EMBO J. 18: 3990–4003
McConkey DJ, Chandra J, Wright S, Plunkett W, McDonnell TJ, Reed JC, Keating M . 1996 J. Immunol. 156: 2624–2630
Medh RD, Thompson EB . 2000 Cell Tissue Res. 301: 101–
Meijerink JP, Mensink EJ, Wang K, Sedlak TW, Sloetjes AW, de Witte T, Waksman G, Korsmeyer SJ . 1998 Blood 91: 2991–2997
Melnick A, Licht JD . 1999 Blood 93: 3167–3215
Micheau O, Lens S, Gaide O, Alevizopoulos K, Tschopp J . 2001 Mol. Cell. Biol 21: 5299–5305
Miyashita T, Reed JC . 1995 Cell 80: 293–299
Morgan J, Yin Y, Borowsky A, Kuo F, Nourmand N, Koontz J, Reynolds C, Soreng L, Griffin C, Graeme-Cook F, Harris N, Weisenburger D, Pinkus G, Fletcher J, Sklar J . 1999 Cancer Res. 59: 6205–6213
Motegi M, Yonezumi M, Suzuki H, Suzuki R, Hosokawa Y, Hosaka S, Kodera Y, Morishima Y, Nakamura S, Seto M . 2000 Am. J. Pathol. 156: 807–812
Muller S, Matunis MJ, Dejean A . 1998 EMBO J. 17: 61–70
Nagata S . 1997 Cell 88: 355–365
Nakagawa T, Zhu H, Morishima N, Ll E, Xu J, Yankner B, Yuan J . 2000 Nature 403: 98–103
Nakano K, Vousden KH . 2001 Mol. Cell. 7: 683–694
Newmeyer D, Farschon DM, Reed JC . 1994 Cell 79: 353–364
Ng FWH, Nguyen M, Kwan T, Branton PE, Nicholson DW, Cromlish JA, Shore GC . 1997 J. Cell Biol. 39: 327–338
Niitsu N, Sasaki K, Umeda M . 1999 Leukemia 13: 1434–1440
Oda E, Ohki R, Murasawa H, Nemoto J, Shibue T, Yamashita T, Tokino T, Taniguchi T, Tanaka N . 2000 Science 288: 1053–1058
Oehm A, Behrmann I, Falk W, Pawlita M, Maier G, Klas C, Li-Weber M, Richards S, Dhein J, Trauth BC, Ponstingl H, Krammer PH . 1992 J. Biol. Chem. 267: 10709–10715
Ong YL, McMullin MF, Bailie KE, Lappin TR, Jones FG, Irvine AE . 2000 Br. J. Haematol. 111: 182–189
Osorio LM, Aguilar-Santelises M, De Santiago A, Hachiya T, Mellstedt H, Jondal M . 2001 Eur. J. Haematol. 66: 342–346
Owen-Schaub LB, Zhang W, Cusack JC, Angelo LS, Santee SM, Fujiwara T, Roth JA, Deissertoth AB, Zhang WW, Kruzel E et al . 1995 Mol. Cell. Biol 15: 3032–3040
Ozes ON, Mayo LD, Gustin JA, Pfeffer SR, Pfeffer LM, Donner DB . 1999 Nature 401: 82–85
Parrish J, Li L, Klotz K, Ledwich D, Wang X, Xue D . 2001 Nature 412: 90–94
Pathan N, Marusawa H, Krajewska M, Matsuzawa S-I, Kim H, Okada K, Torii S, Kitada S, Krajewski S, Welsh K, Pio F, Godzik A, Reed JC . 2001 J. Biol. Chem. 276: 32220–32229
Pekarsky Y, Hallas C, Palamarchuk A, Koval A, Bullrich F, Hirata Y, Bichi R, Letofsky J, Croce CM . 2001 Proc. Natl. Acad. Sci. USA 98: 3690–3694
Pekarsky Y, Koval A, Hallas C, Bichi R, Tresini M, Malstrom S, Russo G, Tsichlis P, Croce CM . 2000 Proc. Natl. Acad. Sci. USA 97: 3028–3033
Pepper C, Bentley P, Hoy T . 1996 Br. J. Haematol. 95: 513–517
Pepper C, Hoy T, Bentley D . 1998a Br. J. Oncol. 76: 935–938
Pepper C, Hoy T, Bentley P . 1998b Leuk. Lymphoma 28: 355–361
Perucho M . 1996 Biol. Chem. 377: 675–684
Pettitt AR, Sherrington PD, Stewart G, Cawley JC, Taylor AM, Stankovic T . 2001 Blood 98: 814–822
Prives C . 1998 Cell 95: 5–8
Radich JP . 2001 Hematol. Oncol. North Am. 15: 21–36
Rampino N, Yamamoto H, Ionov Y, Li Y, Sawai H, Reed JC, Perucho M . 1997 Science 275: 967–969
Rao PH, Houldsworth J, Dyomina K, Parsa NZ, Cigudosa JC, Louie DC, Popplewell L, Offit K, Jhanwar SC, Chaganti RS . 1998 Blood 92: 234–240
Rayet B, Gelinas C . 1999 Oncogene 18: 6938–6947
Reed J . 1998 Oncogene 17: 3225–3236
Reed J . 1999a J. Clin. Oncol. 17: 2941
Reed J . 1999b J. Natl. Cancer Inst 91: 1099–1100
Reed J, Tanaka S . 1993 Leuk. Lymphoma 10: 157–163
Reed JC . 1997 Cell 91: 559–562
Rinkenberger J, Korsmeyer S . 1997 Curr. Opin. Genet. Develop. 7: 589–596
Rossi A, Kapahi P, Natoli G, Takahashi T, Chen Y, Karin M, Santoro MG . 2000 Nature 403: 103–108
Roy N, Deveraux QL, Takashashi R, Salvesen GS, Reed JC . 1997 EMBO J. 16: 6914–6925
Ruland J, Duncan GS, Elia A, del Barco Barrentes I, Nguyen L, Plyte S, Millar DG, Bouchard D, Wakeham A, Ohashi PS, Mak TW . 2001 Cell 104: 33–42
Sakai A, Thieblemont C, Wellmann A, Jaffe ES, Raffeld M . 1998 Blood 92: 3410–3415
Salvesen GS, Dixit VM . 1997 Cell 91: 443–446
Shikami M, Miwa H, Nishii K, Takahashi T, Sekine T, Mahmud N, Nishikawa M, Shiku H, Kamada N, Kita K . 1999 Leukemia 13: 358–368
Shinobu N, Maeda T, Aso T, Ito T, Kondo T, Koike K, Hatakeyama M . 1999 J. Biol. Chem. 274: 17003–17010
Silverman N, Maniatis T . 2001 Genes Dev. 15: 2321–2342
Simms LA, Radford-Smith G, Biden KG, Buttenshaw R, Cummings M, Jass JR, Young J, Meltzer SJ, Leggett BA . 1998 Oncogene 17: 2003–2008
Slupianek A, Nieborowska-Skorska M, Hoser G, Morrione A, Majewski M, Xue L, Morris SW, Wasik MA, Skorski T . 2001 Cancer Res. 61: 2194–2199
Snell V, Clodi K, Zhao S, Goodwin R, Thomas EK, Morris SW, Kadin ME, Cabanillas F, Andreeff M, Younes A . 1997 Br. J. Haematol. 99: 618–624
Soulier L, Pierron G, Vecchione D, Garand R, Brizard F, Sigaux F, Stern MH, Aurias A . 2001 Genes Chromosomes Cancer 31: 248–254
Srinivasula SM, Hegde R, Saleh A, Datta P, Shiozaki E, Chai J, Lee R-A, Robbins PD, Fernandes-Alnemri T, Shi Y, Alnermi ES . 2001 Nature 410: 112–116
Stambolic V, Mak TW, Woodgett JR . 1999 Oncogene 18: 6094–6103
Stamkovic T, Taylor AM, Yuille MR, Vorechovsky I . 2001 Blood 97: 1517–1518
Strasser A, Huang DCS, Vaux DL . 1997 Biochim. Biophys. Acta 1333: F151–F178
Stroka DM, Badrichani AZ, Bach FH, Ferran C . 1999 Blood 93: 3803–3810
Suh N, Wang Y, Williams CR, Risingsong R, Gilmer T, Willson TM, Sporn M.B . 1999 Cancer Res. 59: 5671–5673
Susin S, Lorenzo H, Zamzami N, Marzo I, Snow B, Brothers G, Mangion J, Jacotot E, Costantini P, Loeffler M, Larochette N, Goodlett D, Aebersold R, Siderovski D, Penninger J, Kroemer G . 1999 Nature 397: 441–446
Suzuki Y, Imai Y, Nakayama H, Takahashi K, Takio K, Takahashi R . 2001 Mol. Cell. 8: 613–621
Takahashi T, Tanaka M, Brannan CI, Jenkins NA, Copeland NG, Suda T, Nagata S . 1994 Cell 76: 969–976
Takayama S, Reed JC . 2001 Nature Cell Biol. 3: E237–E241
Takita J, Yang HW, Chen YY, Hanada R, Yamamoto K, Teitz T, Kidd V, Hayashi Y . 2001 Oncogene 20: 4424–4432
Tanaka S, Louie D, Kant J, Reed J . 1992 Blood 79: 229–237
Tang D, Lahti JM, Kidd VJ . 2000 J. Biol. Chem. 275: 9303–9307
Teitz T, Wei T, Valentine MB, Vanin EF, Grenet J, Valentine VA, Behm FG, Look AT, Lahti JM, Kidd VJ . 2000 Nat. Med. 6: 529–535
Thornberry N, Lazebnik Y . 1998 Science 281: 1312–1316
Thornberry N, Rano T, Peterson E, Rasper D, Timkey T, Garcia-Calvo M, Houtzager V, Nordstrom P, Roy S, Vaillancourt J, Chapman K, Nicholson D . 1997 J. Biol. Chem. 272: 17907–17911
Torii S, Egan DA, Evans RA, Reed JC . 1999 EMBO J. 18: 6037–6049
Tschopp J, Martinon F, Hofmann K . 1999 Curr. Biol. 9: R381–R384
Tsujimoto Y, Croce C . 1986 Proc. Natl. Acad. Sci. USA 83: 5214–5218
Tzung S, Kim KM, Basanez G, Giedt CD, Simon J, Zimmerberg J, Zhang KYJ, Hockenbery DM . 2001 Nature Cell Biol. 3: 183–192
Uren AG, O'Rourke K, Aravind L, Pisabarro MT, Seshagirl S, Koonin EV, Dixit VM . 2000 Mol. Cell. 6: 961–967
Varfolomeev E, Schuchmann M, Luria V, Chiannilkulchai N, Beckmann J, Mett I, Rebrikov D, Brodianski V, Kemper O, Kollet O, Lapidot T, Soffer D, Sobe T, Avraham K, Goncharov T, Holtmann H, Lonai P, Wallach D . 1998 Immunity 9: 267–276
Vaux DL, Strasser A . 1996 Proc. Natl. Acad. Sci. USA 93: 2239–2244
Verhagen AM, Ekert PG, Pakusch M, Silke J, Connolly LM, Reid GE, Moritz RL, Simpson RJ, Vaux DL . 2000 Cell 102: 43–53
Vogelstein B, Lane D, Levine AJ . 2000 Nature 408: 307–310
Wallach D, Varfolomeev EE, Malinin NL, Goltsev YV, Kovalenko AV, Boldin MP . 1999 Ann. Rev. Immunol. 17: 331–367
Wang C, Mayo M, Korneluk R, Goeddel D, Baldwin A . 1998a Science 281: 1680–1683
Wang J, Zheng L, Lobito A, Chan FK, Dale J, Sneller M, Yao X, Puck JM, Straus SE, Lenardo MJ . 1999 Cell 98: 47–58
Wang J-L, Liu D, Zhang Z-J, Shan S, Han X, Srinivascula AM, Croce CM, Alnemri ES, Huang Z . 2000 Proc. Natl. Acad. Sci. USA 97: 7124–7129
Wang JY . 2000 Oncogene 19: 5643–5650
Wang Z-G, Ruggero D, Ronchetti S, Zhong S, Gaboli M, Rivi R, Pandolfi P . 1998b Nat. Genet. 20: 266–272
Watanabe-Fukunaga R, Brannan CI, Copeland NG, Jenkins NA, Nagata S . 1992 Nature 356: 314–317
Weiss LM, Warnke RA, Sklar J, Cleary ML . 1987 N. Engl. J. Med. 317: 1185–1189
Willis T, Jadayel D, Peng H, Perry A, Rauf-Abdul M, Price H, Karran L, Majekodunmi O, Wlodarska I, Pan L, Crook T, Hamoudi R, Isaacson P, Dyer M . 1999 Cell 96: 35–45
Wu GS, Burns TF, McDonald ERR, Jiang W, Meng R, Krantz ID, Kao G, Gan DD, Zhou JY, Muschel R, Hamilton SR, Spinner NB, Markowitz S, Wu G, El-Deiry WS . 1997 Nat. Genet. 17: 141–143
Wuchter C, Krappmann D, Cai Z, Ruppert V, Scheidereit C, Dorken B, Ludwig WD, Karawajew L . 2001 Leukemia 15: 921–928
Wyllie AH . 1997a Eur. J. Cell Biol. 73: 189–197
Wyllie AH . 1997b British Medical Bulletin 53: 451–465
Xiao G, Harhaj EW, Sun S-C . 2001 Mol. Cell. 7: 401–409
Yan M, Lee J, Schilbach S, Goddard A, Dixit V . 1999 J. Biol. Chem. 275: 10287–10292
Yang Y, Fang S, Jensen J, Weissman A, Ashwell J . 2000 Science 288: 874–877
Yin C, Knudson CM, Korsmeyer SJ, Van Dyke T . 1997 Nature 385: 637–640
Yoneda T, Imaizumi K, Oono K, Yui D, Gomi F, Katayama T, Tohyama M . 2001 J. Biol. Chem. 276: 13935–13940
Yu J, Zhang L, Hwang PM, Kinzler KW, Vogelstein B . 2001 Mol. Cell. 7: 673–682
Yuan J . 1997 Curr. Opin. Cell Biol 9: 247–251
Yuille MR, Houlston RS, Catovsky D . 1998 Leukemia 12: 1696–1698
Zapata JM, Krajewska M, Krajewski S, Kitada S, Welsh K, Monks A, McCloskey N, Gordon J, Kipps T, Goscoyne RD, Shabaik A, Reed JC . 2000 J. Immunol. 165: 5084–5096
Zhang H, Xu Q, Krajewski S, Krajewska M, Xie Z, Fuess S, Kitada S, Pawloski K, Godzik A, Reed JC . 2000 Proc. Natl. Acad. Sci. USA 97: 2597–2602
Zheng TS, Hunot S, Kuida K, Momoi T, Srinivasan A, Nicholson DW, Lazebnik Y, Flavell RA . 2000 Nat. Med. 6: 1241–1247
Zhong S, Salomoni P, Ronchetti S, Guo A, Ruggero D, Pandolfi PP . 2000 J. Exp. Med. 191: 631–639
Zhou Q, Snipas S, Orth K, Muzio M, Dixit VM, Salvesen GS . 1997 J. Biol. Chem. 272: 7797–7800
Acknowledgements
We thank R Cornell and A Sawyer for manuscript preparation, and gratefully acknowledge the generous support of the National Cancer Institute (NCI), American Society of Hematology, and Canadian Institute of Health Research.
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Kitada, S., Pedersen, I., Schimmer, A. et al. Dysregulation of apoptosis genes in hematopoietic malignancies. Oncogene 21, 3459–3474 (2002). https://doi.org/10.1038/sj.onc.1205327
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DOI: https://doi.org/10.1038/sj.onc.1205327
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