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Id proteins in cell cycle control and cellular senescence

Oncogene volume 20, pages 8317–8325 (2001)Cite this article

Abstract

The Id family of helix–loop–helix (HLH) proteins are thought to affect the balance between cell growth and differentiation by negatively regulating the function of basic–helix–loop–helix (bHLH) transcription factors. Although it has been suggested for some time that Id is involved in cell cycle regulation, little is known about the molecular mechanism of this control. Recent studies, however, have revealed that Id binds to important cell cycle regulatory proteins other than bHLH proteins. Two such proteins, pRB (retinoblastoma tumour suppressor protein) family proteins and Ets-family transcription factors are known to play key roles in cell cycle regulation, transformation and tumour suppression. Through the characterization of these pathways we will begin to understand the mechanisms by which Id controls normal and abnormal cell cycle progression.

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Acknowledgements

We thank Drs G Peters, TJ Huot, N Ohtani, M Sugimoto, I Palmero, M Serrano, J Campisi and N Jones for valuable discussion. This work was supported by United Kingdom Cancer Research Campaign.

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  1. CRC Cell Cycle Group, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Wilmslow Road, Manchester, M20 4BX, UK

    Zoe Zebedee & Eiji Hara

  2. Department of Biomolecular Sciences, University of Manchester Institute of Science & Technology (UMIST), Manchester, M60, 1QD, UK

    Eiji Hara

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Correspondence to Eiji Hara.

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Zebedee, Z., Hara, E. Id proteins in cell cycle control and cellular senescence. Oncogene 20, 8317–8325 (2001). https://doi.org/10.1038/sj.onc.1205092

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