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Identification of a prostate-specific G-protein coupled receptor in prostate cancer

Oncogene volume 20, pages 5903–5907 (2001)Cite this article

Abstract

Membrane receptors coupled to heterotrimeric G-proteins play an essential role in the transmission of signals from the extracellular environment to the cytoplasm of the cell. A wide variety of external stimuli, including neurotransmitters, hormones, phospholipids, photons, odorants, taste ligands, and growth factors, can activate specific members of the G-protein coupled receptors (GPCRs). Besides essential functions in fully differentiated cells and tissues, GPCRs are also involved in embryogenesis, tissue regeneration, cell growth stimulation, and cell proliferation. In this study, we identified a novel prostate-specific G-protein coupled receptor that interacts with Gα12 in our yeast two-hybrid assays. The expression of the receptor protein is highly restricted to human prostate tissues using multiple-tissue Northern blot analysis, and tissue expression array. Furthermore, the expression of prostate-specific receptor is increased significantly in prostate tumors in comparison with the matched normal prostate tissues using PCR and Southern blot analysis, suggesting a potential role of this tissue-specific G-protein coupled receptor in prostate cancer development.

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References

  • Abe K, Kusakabe Y, Tanemura K, Emori Y, Arai S . 1993 J. Biol. Chem. 268: 12033–12039

  • Allen LF, Lefkowitz RJ, Caron MG, Cotecchia S . 1991 Proc. Natl. Acad. Sci. USA 88: 11354–11358

  • Chan AM, Fleming TP, McGovern ES, Chedid M, Miki T, Aaronson SA . 1993 Mol. Cell. Biol. 13: 762–768

  • Collins LR, Ricketts WA, Olefsky JM, Brown JH . 1997 Oncogene 15: 595–600

  • Crespo P, Xu N, Simonds WF, Gutkind JS . 1994 Nature 369: 418–420

  • Dermott JM, Reddy MR, Onesime D, Reddy EP, Dhanasekaran N . 1999 Oncogene 18: 7185–7189

  • Dhanasekaran N, Dermott JM . 1996 Cell Signal 8: 235–245

  • Dhanasekaran N, Heasley LE, Johnson GL . 1995 Endocr. Rev. 16: 259–270

  • Edwards SW, Tan CM, Limbird LE . 2000 Trends Pharmacol. Sci. 21: 304–308

  • Gohla A, Offermanns S, Wilkie TM, Schultz G . 1999 J. Biol. Chem. 274: 17901–17907

  • Gutkind JS . 1998a Oncogene 17: 1331–1342

  • Gutkind JS . 1998b J. Biol. Chem. 273: 1839–1842

  • Gutkind JS, Novotny EA, Brann MR, Robbins KC . 1991 Proc. Natl. Acad. Sci. USA 88: 4703–4707

  • Hart MJ, Jiang X, Kozasa T, Roscoe W, Singer WD, Gilman AG, Sternweis PC, Bollag G . 1998 Science 280: 2112–2114

  • Jiang H, Wu D, Simon MI . 1993 FEBS Lett. 330: 319–322

  • Jiang Y, Ma W, Wan Y, Kozasa T, Hattori S, Huang XY . 1998 Nature 395: 808–813

  • Jones TL, Gutkind JS . 1998 Biochemistry 37: 3196–3202

  • Julius DLT, Jessell TM, Axel R . 1989 Science 244: 1057–1062

  • Kozasa T, Jiang X, Hart MJ, Sternweis PM, Singer WD, Gilman AG, Bollag G, Sternweis PC . 1998 Science 280: 2109–2111

  • Landis CA, Masters SB, Spada A, Pace AM, Bourne HR, Vallar L . 1989 Nature 340: 692–696

  • Lin X, Voyno-Yasenetskaya TA, Hooley R, Lin CY, Orlowski J, Barber DL . 1996 J. Biol. Chem. 271: 22604–22610

  • Lopez-Ilasaca M, Crespo P, Pellici PG, Gutkind JS, Wetzker R . 1997 Science 275: 394–397

  • Lyons JLC, Harsh G, Vallar L, Grunewald K, Feichtinger H, Duh QY, Clark OH, Kawasaki E, Bourne HR, et al . 1990 Science 249: 655–659

  • Marinissen MJ, Chiariello M, Pallante M, Gutkind JS . 1999 Mol. Cell. Biol. 19: 4289–4301

  • Radhika V, Dhanasekaran N . 2001 Oncogene 20: 1607–1614

  • Rhee SG, Choi KD . 1992 Adv. Sec. Mess. Phosphopro. Res. 26: 35–61

  • Simon MI, Strathmann MP, Gautam N . 1991 Science 252: 802–808

  • Voyno-Yasenetskaya TA, Faure MP, Ahn NG, Bourne HR . 1996 J. Biol. Chem. 271: 21081–21087

  • Wess J . 1997 FASEB J. 11: 346–354

  • Whitehead IP, Zohn IE, Der CJ . 2001 Oncogene 20: 1547–1555

  • Xu LL, Stackhouse BG, Florence K, Zhang W, Shanmugam N, Sesterhenn IA, Zou Z, Srikantan V, Augustus M, Roschke V, Carter K, McLeod DG, Moul JW, Soppett D, Srivastava S . 2000 Cancer Res. 60: 6568–6572

  • Xu N, Bradley L, Ambdukar I, Gutkind JS . 1993 Proc. Natl. Acad. Sci. USA 90: 6741–6745

  • Xu N, Voyno-Yasenetskaya T, Gutkind JS . 1994 Biochem. Biophys. Res. Commun. 201: 603–609

  • Young D, Waitches G, Birchmeier C, Fasano O, Wigler M . 1986 Cell 45: 711–719

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Acknowledgements

This work was supported in part by a Scientist Development Grant from American Heart Association National and the Basil O'Connor Starter Scholar Award from March of Dimes Foundation (to M Liu).

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Authors and Affiliations

  1. Center for Cancer Biology and Nutrition, Institute of Biosciences and Technology Houston, TX 77030, Texas, USA

    Chunzhi Xia, Wenbin Ma, Fen Wang & Mingyao Liu

  2. Department of Medical Biochemistry and Genetics, Texas A&M University System Health Science Center, Houston, TX 77030, Texas, USA

    Chunzhi Xia & Mingyao Liu

  3. Genetastix Corporation, 780 Montague Expressway, Suite 303, San José, California, CA 95131, USA

    Shao-bing Hua

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  1. Chunzhi Xia
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Correspondence to Mingyao Liu.

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Xia, C., Ma, W., Wang, F. et al. Identification of a prostate-specific G-protein coupled receptor in prostate cancer. Oncogene 20, 5903–5907 (2001). https://doi.org/10.1038/sj.onc.1204803

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