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All trans retinoic acid in acute promyelocytic leukemia

Oncogene volume 20, pages 7140–7145 (2001)Cite this article

Abstract

All trans retinoic acid (ATRA) is able to induce complete remission (CR) in almost all patients with acute promyelocytic leukemia (APL) through in vivo differentiation of APL blasts. However, it cannot eliminate the leukemic clone and to be effective must be used in combination with anthracycline-based chemotherapy. Experience accumulated over the last 10 years has clearly shown that the combination of ATRA and chemotherapy gives better survival in newly diagnosed APL than chemotherapy alone because of fewer relapses and a higher CR rate experienced by these patients. It is also strongly suggested that maintenance treatment with ATRA, and possibly in combination with low-dose chemotherapy, can further reduce the incidence of relapse. Overall, more than 90% of patients with newly diagnosed APL can achieve CR and about 75% can be cured by the combination of ATRA and chemotherapy.

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Abbreviations

APL:

acute promyelocytic leukemia

ATRA:

all trans retinoic acid

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Authors and Affiliations

  1. Institut Universitaire d'Hématologie, Saint Louis Hospital (AP-HP) 1, avenue Claude Vellefaux, Paris, 75010, France

    Laurent Degos

  2. Shanghaï Institute of Hematology, Rui-Jin Hospital Shanghaï Second Medical University, 197 Rui-Jin Er Road, Shanghaï, PR China

    Zhen Yi Wang

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Correspondence to Laurent Degos.

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Degos, L., Wang, Z. All trans retinoic acid in acute promyelocytic leukemia. Oncogene 20, 7140–7145 (2001). https://doi.org/10.1038/sj.onc.1204763

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