Abstract
The retinoic acid receptor α gene is the target of chromosomal rearrangements in all cases of acute promyelocytic leukemia (APL). This recurrent involvement of RARα in the pathogenesis of APL is likely to reflect an important role played by this receptor during the differentiation of immature myeloid cells to neutrophils. RARα is a negative regulator of promyelocyte differentiation when not complexed with RA, and stimulates this differentiation when bound to RA. Since RARs are dispensable for the generation of mature neutrophils, their role thus appears to be to modulatory, rather than obligatory, for the control of neutrophil differentiation. In vitro, retinoic acid is also a potent inducer of neutrophil cell fate, suggesting that it might play a role in the commitment of pluripotent hematopoietic progenitors to the neutrophil lineage. Thus, the APL translocations target an important regulator of myeloid cell differentiation.
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References
Altucci L, Rossin A, Raffelsberger W, Reitmair A, Chomienne C, Gronemeyer H . 2001 Nature Med. 7: 680–686
Ayer DE, Eisenman RN . 1993 Genes Dev. 7: 2110–2119
Bauer A, Mikulits W, Lagger G, Stengl G, Brosch G, Beug H . 1998 EMBO J. 17: 4291–4303
Boehm MF, Zhang L, Zhi L, McClurg MR, Berger E, Wagoner M, Mais DE, Suto CM, Davies JA, Heyman RA . 1995 J. Med. Chem. 38: 3146–3155
Breitman TR, Selonick SE, Collins SJ . 1980 Proc. Natl. Acad. Sci. USA 77: 2936–2940
Chambon P . 1996 FASEB J. 10: 940–954
Chiba H, Clifford J, Metzger D, Chambon P . 1997 Mol. Cell Biol. 17: 3013–3020
Chih DY, Chumakov AM, Park DJ, Silla AG, Koeffler HP . 1997 Blood 90: 2987–2994
Cultraro CM, Bino T, Segal S . 1997 Mol. Cell Biol. 17: 2353–2359
Dilworth FJ, Fromental-Ramain C, Yamamoto K, Chambon P . 2000 Mol. Cell 6: 1049–1058
Dinnen RD, White SR, Elsayed S, Yeh YI, Ebisuzaki K . 1994 Cell Growth Differ. 5: 855–861
Drach J, McQueen T, Engel H, Andreeff M, Robertson KA, Collins SJ, Malavasi F, Mehta K . 1994 Cancer Res. 54: 1746–1752
Du C, Redner RL, Cooke MP, Lavau C . 1999 Blood 94: 793–802
Fajas L, Fruchart JC, Auwerx J . 1998 Curr. Opin. Cell. Biol. 10: 165–173
Foley KP, McArthur GA, Queva C, Hurlin PJ, Soriano P, Eisenman RN . 1998 EMBO J. 17: 774–785
Fraichard A, Chassande O, Plateroti M, Roux JP, Trouillas J, Dehay C, Legrand C, Gauthier K, Kedinger M, Malaval L, Rousset B, Samarut J . 1997 EMBO J. 16: 4412–4420
Ghyselinck NB, Dupe V, Dierich A, Messaddeq N, Garnier JM, Rochette-Egly C, Chambon P, Mark M . 1997 Int. J. Dev. Biol. 41: 425–447
Glass CK, Rosenfeld MG . 2000 Genes Dev. 14: 121–141
Gratas C, Menot ML, Dresch C, Chomienne C . 1993 Leukemia 7: 1156–1162
Griep AE, Westphal H . 1988 Proc. Natl. Acad. Sci. USA 85: 6806–6810
Grignani F, De Matteis S, Nervi C, Tomassoni L, Gelmetti V, Cioce M, Fanelli M, Ruthardt M, Ferrara FF, Zamir I, Seiser C, Lazar MA, Minucci S, Pelicci PG . 1998 Nature 391: 815–818
Guidez F, Ivins S, Zhu J, Soderstrom M, Waxman S, Zelent A . 1998 Blood 91: 2634–2642
Hashimoto H, Curty F, Borges P, Lee CE, Abel ED, Elmquist JK, Cohen RN, Wondisdorf F . 2001 Proc. Natl. Acad. Sci. USA 98: 3998–4003
He LZ, Guidez F, Tribioli C, Peruzzi D, Ruthardt M, Zelent A, Pandolfi PP . 1998 Nat. Genet. 18: 126–135
Hong SH, David G, Wong CW, Dejean A, Privalsky ML . 1997 Proc. Natl. Acad. Sci. USA 94: 9028–9033
Hurlin PJ, Queva C, Koskinen PJ, Steingrimsson E, Ayer DE, Copeland NG, Jenkins NA, Eisenman RN . 1995 EMBO J. 14: 5646–5659
Imai T, Jiang M, Chambon P, Metzger D . 2001a Proc. Natl. Acad. Sci. USA 98: 224–228
Imai T, Jiang M, Kastner P, Chambon P, Metzger D . 2001b Proc. Natl. Acad. Sci. USA 98: 4581–4586
Jiang H, Lin J, Su ZZ, Collart FR, Huberman E, Fisher PB . 1994 Oncogene 9: 3397–3406
Kastner P, Grondona JM, Mark M, Gansmuller A, LeMeur M, Decimo D, Vonesch JL, Dolle P, Chambon P . 1994 Cell 78: 987–1003
Kastner P, Lawrence HJ, Waltzinger C, Ghyselinck N, Chambon P, Chan S . 2001 Blood 97: 1314–1320
Kastner P, Mark M, Chambon P . 1995 Cell 83: 859–869
Kastner P, Mark M, Ghyselinck N, Krezel W, Dupe V, Grondona JM, Chambon P . 1997 Development 124: 313–326
Kastner P, Mark M, Leid M, Gansmuller A, Chin W, Grondona JM, Decimo D, Krezel W, Dierich A, Chambon P . 1996 Genes Dev. 10: 80–92
Kastner P, Perez A, Lutz Y, Rochette-Egly C, Gaub MP, Durand B, Lanotte M, Berger R, Chambon P . 1992 EMBO J. 11: 629–642
Krezel W, Dupe V, Mark M, Dierich A, Kastner P, Chambon P . 1996 Proc. Natl. Acad. Sci. USA 93: 9010–9014
Krezel W, Ghyselinck N, Samad TA, Dupe V, Kastner P, Borrelli E, Chambon P . 1998 Science 279: 863–867
Kuwata T, Wang IM, Tamura T, Ponnamperuma RM, Levine R, Holmes KL, Morse HC, De Luca LM, Ozato K . 2000 Blood 95: 3349–3356
Labbaye C, Valtieri M, Testa U, Giampaolo A, Meccia E, Sterpetti P, Parolini I, Pelosi E, Bulgarini D, Cayre YE . 1994 Blood 83: 651–656
Labrecque J, Allan D, Chambon P, Iscove NN, Lohnes D, Hoang T . 1998 Blood 92: 607–615
Lane MD, Tang QQ, Jiang MS . 1999 Biochem. Biophys. Res. Commun. 266: 677–683
Lawson ND, Berliner N . 1999 Exp. Hematol. 27: 1355–1367
Lawson ND, Zain M, Zibello T, Picciotto MR, Nairn AC, Berliner N . 1999 Exp. Hematol. 27: 1682–1690
Leroy P, Krust A, Zelent A, Mendelsohn C, Garnier JM, Kastner P, Dierich A, Chambon P . 1991 EMBO J. 10: 59–69
Li M, Indra AK, Warot X, Brocard J, Messaddeq N, Kato S, Metzger D, Chambon P . 2000 Nature 407: 633–636
Lin RJ, Nagy L, Inoue S, Shao W, Miller Jr WH, Evans RM . 1998 Nature 391: 811–814
Liu M, Lavarone A, Freedman LP . 1996a J. Biol. Chem. 271: 31723–31728
Liu M, Lee MH, Cohen M, Bommakanti M, Freedman LP . 1996b Genes Dev. 10: 142–153
Liu TX, Zhang JW, Tao J, Zhang RB, Zhang QH, Zhao CJ, Tong JH, Lanotte M, Waxman S, Chen SJ, Mao M, Hu GX, Zhu L, Chen Z . 2000 Blood 96: 1496–1504
Lohnes D, Kastner P, Dierich A, Mark M, LeMeur M, Chambon P . 1993 Cell 73: 643–658
Lohnes D, Mark M, Mendelsohn C, Dolle P, Dierich A, Gorry P, Gansmuller A, Chambon P . 1994 Development 120: 2723–2748
Lufkin T, Lohnes D, Mark M, Dierich A, Gorry P, Gaub MP, LeMeur M, Chambon P . 1993 Proc. Natl. Acad. Sci. USA 90: 7225–7229
Mascrez B, Mark M, Dierich A, Ghyselinck NB, Kastner P, Chambon P . 1998 Development 125: 4691–4707
Mascrez B, Mark M, Krezel W, Dupé V, Lemeur M, Ghyselinck N, Chambon P . 2001 Development 128: 2049–2062
Matikainen S, Ronni T, Hurme M, Pine R, Julkunen I . 1996 Blood 88: 114–123
Mehta K, McQueen T, Manshouri T, Andreeff M, Collins S, Albitar M . 1997 Blood 89: 3607–3614
Mehta K, McQueen T, Neamati N, Collins S, Andreeff M . 1996 Cell Growth Differ. 7: 179–186
Melnick A, Licht JD . 1999 Blood 93: 3167–3215
Mendelsohn C, Lohnes D, Decimo D, Lufkin T, LeMeur M, Chambon P, Mark M . 1994 Development 120: 2749–2771
Metz T, Graf T . 1992 Oncogene 7: 597–605
Minucci S, Pelicci PG . 1999 Semin. Cell. Dev. Biol. 10: 215–225
Monczak Y, Trudel M, Lamph WW, Miller Jr WH . 1997 Blood 90: 3345–3355
Nagpal S, Friant S, Nakshatri H, Chambon P . 1993 EMBO J. 12: 2349–2360
Nagpal S, Zelent A, Chambon P . 1992 Proc. Natl. Acad. Sci. USA 89: 2718–2722
Nagy L, Kao HY, Chakravarti D, Lin RJ, Hassig CA, Ayer DE, Schreiber SL, Evans RM . 1997 Cell 89: 373–380
Niederreither K, Subbarayan V, Dolle P, Chambon P . 1999 Nat. Genet. 21: 444–448
Onodera M, Kunisada T, Nishikawa S, Sakiyama Y, Matsumoto S . 1995 Oncogene 11: 1291–1298
Pandolfi PP, Alcalay M, Fagioli M, Zangrilli D, Mencarelli A, Diverio D, Biondi A, Lo Coco F, Rambaldi A, Grignani F . 1992 EMBO J. 11: 1397–1407
Park DJ, Chumakov AM, Vuong PT, Chih DY, Gombart AF, Miller Jr WH, Koeffler HP . 1999 J. Clin. Invest. 103: 1399–1408
Paul CC, Mahrer S, Tolbert M, Elbert BL, Wong I, Ackerman SJ, Baumann MA . 1995 Blood 86: 3737–3744
Pulverer B, Sommer A, McArthur GA, Eisenman RN, Luscher B . 2000 J. Cell. Physiol. 183: 399–410
Purton LE, Bernstein ID, Collins SJ . 1999 Blood 94: 483–495
Purton LE, Bernstein ID, Collins SJ . 2000 Blood 95: 470–477
Rochette-Egly C, Chambon P . 2001 Histol. Histopathol. 16: 902–922
Rodriguez-Pena A . 1999 J. Neurobiol. 40: 497–512
Subbarayan V, Kastner P, Mark M, Dierich A, Gorry P, Chambon P . 1997 Mech. Dev. 66: 131–142
Sucov HM, Dyson E, Gumeringer CL, Price J, Chien KR, Evans RM . 1994 Genes Dev. 8: 1007–1018
Taneja R, Rochette-Egly C, Plassat JL, Penna L, Gaub MP, Chambon P . 1997 EMBO J. 16: 6452–6465
Tocci A, Parolini I, Gabbianelli M, Testa U, Luchetti L, Samoggia P, Masella B, Russo G, Valtieri M, Peschle C . 1996 Blood 88: 2878–2888
Tsai S, Bartelmez S, Sitnicka E, Collins S . 1994 Genes Dev. 8: 2831–2841
Tsai S, Collins SJ . 1993 Proc. Natl. Acad. Sci. USA 90: 7153–7157
Ueno H, Kizaki M, Matsushita H, Muto A, Yamato K, Nishihara T, Hida T, Yoshimura H, Koeffler HP, Ikeda Y . 1998 Leuk. Res. 22: 517–525
van Bockstaele DR, Lenjou M, Snoeck HW, Lardon F, Stryckmans P, Peetermans ME . 1993 Ann. Hematol. 66: 61–66
Yamanaka R, Barlow C, Lekstrom-Himes J, Castilla LH, Liu PP, Eckhaus M, Decker T, Wynshaw-Boris A, Xanthopoulos KG . 1997 Proc. Natl. Acad. Sci. USA 94: 13187–13192
Zauli G, Visani G, Vitale M, Gibellini D, Bertolaso L, Capitani S . 1995 Br. J. Haematol. 90: 274–282
Acknowledgements
The work of our laboratory was supported by the Association pour la Recherche sur le Cancer, the Centre National pour la Recherche Scientifique, the Institut National de la Santé et de la Recherche Médicale, the Hôpital Universitaire de Strasbourg, the Collège de France and Bristol-Myers Squibb.
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Kastner, P., Chan, S. Function of RARα during the maturation of neutrophils. Oncogene 20, 7178–7185 (2001). https://doi.org/10.1038/sj.onc.1204757
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