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Function of RARα during the maturation of neutrophils

Abstract

The retinoic acid receptor α gene is the target of chromosomal rearrangements in all cases of acute promyelocytic leukemia (APL). This recurrent involvement of RARα in the pathogenesis of APL is likely to reflect an important role played by this receptor during the differentiation of immature myeloid cells to neutrophils. RARα is a negative regulator of promyelocyte differentiation when not complexed with RA, and stimulates this differentiation when bound to RA. Since RARs are dispensable for the generation of mature neutrophils, their role thus appears to be to modulatory, rather than obligatory, for the control of neutrophil differentiation. In vitro, retinoic acid is also a potent inducer of neutrophil cell fate, suggesting that it might play a role in the commitment of pluripotent hematopoietic progenitors to the neutrophil lineage. Thus, the APL translocations target an important regulator of myeloid cell differentiation.

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References

  • Altucci L, Rossin A, Raffelsberger W, Reitmair A, Chomienne C, Gronemeyer H . 2001 Nature Med. 7: 680–686

  • Ayer DE, Eisenman RN . 1993 Genes Dev. 7: 2110–2119

  • Bauer A, Mikulits W, Lagger G, Stengl G, Brosch G, Beug H . 1998 EMBO J. 17: 4291–4303

  • Boehm MF, Zhang L, Zhi L, McClurg MR, Berger E, Wagoner M, Mais DE, Suto CM, Davies JA, Heyman RA . 1995 J. Med. Chem. 38: 3146–3155

  • Breitman TR, Selonick SE, Collins SJ . 1980 Proc. Natl. Acad. Sci. USA 77: 2936–2940

  • Chambon P . 1996 FASEB J. 10: 940–954

  • Chiba H, Clifford J, Metzger D, Chambon P . 1997 Mol. Cell Biol. 17: 3013–3020

  • Chih DY, Chumakov AM, Park DJ, Silla AG, Koeffler HP . 1997 Blood 90: 2987–2994

  • Cultraro CM, Bino T, Segal S . 1997 Mol. Cell Biol. 17: 2353–2359

  • Dilworth FJ, Fromental-Ramain C, Yamamoto K, Chambon P . 2000 Mol. Cell 6: 1049–1058

  • Dinnen RD, White SR, Elsayed S, Yeh YI, Ebisuzaki K . 1994 Cell Growth Differ. 5: 855–861

  • Drach J, McQueen T, Engel H, Andreeff M, Robertson KA, Collins SJ, Malavasi F, Mehta K . 1994 Cancer Res. 54: 1746–1752

  • Du C, Redner RL, Cooke MP, Lavau C . 1999 Blood 94: 793–802

  • Fajas L, Fruchart JC, Auwerx J . 1998 Curr. Opin. Cell. Biol. 10: 165–173

  • Foley KP, McArthur GA, Queva C, Hurlin PJ, Soriano P, Eisenman RN . 1998 EMBO J. 17: 774–785

  • Fraichard A, Chassande O, Plateroti M, Roux JP, Trouillas J, Dehay C, Legrand C, Gauthier K, Kedinger M, Malaval L, Rousset B, Samarut J . 1997 EMBO J. 16: 4412–4420

  • Ghyselinck NB, Dupe V, Dierich A, Messaddeq N, Garnier JM, Rochette-Egly C, Chambon P, Mark M . 1997 Int. J. Dev. Biol. 41: 425–447

  • Glass CK, Rosenfeld MG . 2000 Genes Dev. 14: 121–141

  • Gratas C, Menot ML, Dresch C, Chomienne C . 1993 Leukemia 7: 1156–1162

  • Griep AE, Westphal H . 1988 Proc. Natl. Acad. Sci. USA 85: 6806–6810

  • Grignani F, De Matteis S, Nervi C, Tomassoni L, Gelmetti V, Cioce M, Fanelli M, Ruthardt M, Ferrara FF, Zamir I, Seiser C, Lazar MA, Minucci S, Pelicci PG . 1998 Nature 391: 815–818

  • Guidez F, Ivins S, Zhu J, Soderstrom M, Waxman S, Zelent A . 1998 Blood 91: 2634–2642

  • Hashimoto H, Curty F, Borges P, Lee CE, Abel ED, Elmquist JK, Cohen RN, Wondisdorf F . 2001 Proc. Natl. Acad. Sci. USA 98: 3998–4003

  • He LZ, Guidez F, Tribioli C, Peruzzi D, Ruthardt M, Zelent A, Pandolfi PP . 1998 Nat. Genet. 18: 126–135

  • Hong SH, David G, Wong CW, Dejean A, Privalsky ML . 1997 Proc. Natl. Acad. Sci. USA 94: 9028–9033

  • Hurlin PJ, Queva C, Koskinen PJ, Steingrimsson E, Ayer DE, Copeland NG, Jenkins NA, Eisenman RN . 1995 EMBO J. 14: 5646–5659

  • Imai T, Jiang M, Chambon P, Metzger D . 2001a Proc. Natl. Acad. Sci. USA 98: 224–228

  • Imai T, Jiang M, Kastner P, Chambon P, Metzger D . 2001b Proc. Natl. Acad. Sci. USA 98: 4581–4586

  • Jiang H, Lin J, Su ZZ, Collart FR, Huberman E, Fisher PB . 1994 Oncogene 9: 3397–3406

  • Kastner P, Grondona JM, Mark M, Gansmuller A, LeMeur M, Decimo D, Vonesch JL, Dolle P, Chambon P . 1994 Cell 78: 987–1003

  • Kastner P, Lawrence HJ, Waltzinger C, Ghyselinck N, Chambon P, Chan S . 2001 Blood 97: 1314–1320

  • Kastner P, Mark M, Chambon P . 1995 Cell 83: 859–869

  • Kastner P, Mark M, Ghyselinck N, Krezel W, Dupe V, Grondona JM, Chambon P . 1997 Development 124: 313–326

  • Kastner P, Mark M, Leid M, Gansmuller A, Chin W, Grondona JM, Decimo D, Krezel W, Dierich A, Chambon P . 1996 Genes Dev. 10: 80–92

  • Kastner P, Perez A, Lutz Y, Rochette-Egly C, Gaub MP, Durand B, Lanotte M, Berger R, Chambon P . 1992 EMBO J. 11: 629–642

  • Krezel W, Dupe V, Mark M, Dierich A, Kastner P, Chambon P . 1996 Proc. Natl. Acad. Sci. USA 93: 9010–9014

  • Krezel W, Ghyselinck N, Samad TA, Dupe V, Kastner P, Borrelli E, Chambon P . 1998 Science 279: 863–867

  • Kuwata T, Wang IM, Tamura T, Ponnamperuma RM, Levine R, Holmes KL, Morse HC, De Luca LM, Ozato K . 2000 Blood 95: 3349–3356

  • Labbaye C, Valtieri M, Testa U, Giampaolo A, Meccia E, Sterpetti P, Parolini I, Pelosi E, Bulgarini D, Cayre YE . 1994 Blood 83: 651–656

  • Labrecque J, Allan D, Chambon P, Iscove NN, Lohnes D, Hoang T . 1998 Blood 92: 607–615

  • Lane MD, Tang QQ, Jiang MS . 1999 Biochem. Biophys. Res. Commun. 266: 677–683

  • Lawson ND, Berliner N . 1999 Exp. Hematol. 27: 1355–1367

  • Lawson ND, Zain M, Zibello T, Picciotto MR, Nairn AC, Berliner N . 1999 Exp. Hematol. 27: 1682–1690

  • Leroy P, Krust A, Zelent A, Mendelsohn C, Garnier JM, Kastner P, Dierich A, Chambon P . 1991 EMBO J. 10: 59–69

  • Li M, Indra AK, Warot X, Brocard J, Messaddeq N, Kato S, Metzger D, Chambon P . 2000 Nature 407: 633–636

  • Lin RJ, Nagy L, Inoue S, Shao W, Miller Jr WH, Evans RM . 1998 Nature 391: 811–814

  • Liu M, Lavarone A, Freedman LP . 1996a J. Biol. Chem. 271: 31723–31728

  • Liu M, Lee MH, Cohen M, Bommakanti M, Freedman LP . 1996b Genes Dev. 10: 142–153

  • Liu TX, Zhang JW, Tao J, Zhang RB, Zhang QH, Zhao CJ, Tong JH, Lanotte M, Waxman S, Chen SJ, Mao M, Hu GX, Zhu L, Chen Z . 2000 Blood 96: 1496–1504

  • Lohnes D, Kastner P, Dierich A, Mark M, LeMeur M, Chambon P . 1993 Cell 73: 643–658

  • Lohnes D, Mark M, Mendelsohn C, Dolle P, Dierich A, Gorry P, Gansmuller A, Chambon P . 1994 Development 120: 2723–2748

  • Lufkin T, Lohnes D, Mark M, Dierich A, Gorry P, Gaub MP, LeMeur M, Chambon P . 1993 Proc. Natl. Acad. Sci. USA 90: 7225–7229

  • Mascrez B, Mark M, Dierich A, Ghyselinck NB, Kastner P, Chambon P . 1998 Development 125: 4691–4707

  • Mascrez B, Mark M, Krezel W, Dupé V, Lemeur M, Ghyselinck N, Chambon P . 2001 Development 128: 2049–2062

  • Matikainen S, Ronni T, Hurme M, Pine R, Julkunen I . 1996 Blood 88: 114–123

  • Mehta K, McQueen T, Manshouri T, Andreeff M, Collins S, Albitar M . 1997 Blood 89: 3607–3614

  • Mehta K, McQueen T, Neamati N, Collins S, Andreeff M . 1996 Cell Growth Differ. 7: 179–186

  • Melnick A, Licht JD . 1999 Blood 93: 3167–3215

  • Mendelsohn C, Lohnes D, Decimo D, Lufkin T, LeMeur M, Chambon P, Mark M . 1994 Development 120: 2749–2771

  • Metz T, Graf T . 1992 Oncogene 7: 597–605

  • Minucci S, Pelicci PG . 1999 Semin. Cell. Dev. Biol. 10: 215–225

  • Monczak Y, Trudel M, Lamph WW, Miller Jr WH . 1997 Blood 90: 3345–3355

  • Nagpal S, Friant S, Nakshatri H, Chambon P . 1993 EMBO J. 12: 2349–2360

  • Nagpal S, Zelent A, Chambon P . 1992 Proc. Natl. Acad. Sci. USA 89: 2718–2722

  • Nagy L, Kao HY, Chakravarti D, Lin RJ, Hassig CA, Ayer DE, Schreiber SL, Evans RM . 1997 Cell 89: 373–380

  • Niederreither K, Subbarayan V, Dolle P, Chambon P . 1999 Nat. Genet. 21: 444–448

  • Onodera M, Kunisada T, Nishikawa S, Sakiyama Y, Matsumoto S . 1995 Oncogene 11: 1291–1298

  • Pandolfi PP, Alcalay M, Fagioli M, Zangrilli D, Mencarelli A, Diverio D, Biondi A, Lo Coco F, Rambaldi A, Grignani F . 1992 EMBO J. 11: 1397–1407

  • Park DJ, Chumakov AM, Vuong PT, Chih DY, Gombart AF, Miller Jr WH, Koeffler HP . 1999 J. Clin. Invest. 103: 1399–1408

  • Paul CC, Mahrer S, Tolbert M, Elbert BL, Wong I, Ackerman SJ, Baumann MA . 1995 Blood 86: 3737–3744

  • Pulverer B, Sommer A, McArthur GA, Eisenman RN, Luscher B . 2000 J. Cell. Physiol. 183: 399–410

  • Purton LE, Bernstein ID, Collins SJ . 1999 Blood 94: 483–495

  • Purton LE, Bernstein ID, Collins SJ . 2000 Blood 95: 470–477

  • Rochette-Egly C, Chambon P . 2001 Histol. Histopathol. 16: 902–922

  • Rodriguez-Pena A . 1999 J. Neurobiol. 40: 497–512

  • Subbarayan V, Kastner P, Mark M, Dierich A, Gorry P, Chambon P . 1997 Mech. Dev. 66: 131–142

  • Sucov HM, Dyson E, Gumeringer CL, Price J, Chien KR, Evans RM . 1994 Genes Dev. 8: 1007–1018

  • Taneja R, Rochette-Egly C, Plassat JL, Penna L, Gaub MP, Chambon P . 1997 EMBO J. 16: 6452–6465

  • Tocci A, Parolini I, Gabbianelli M, Testa U, Luchetti L, Samoggia P, Masella B, Russo G, Valtieri M, Peschle C . 1996 Blood 88: 2878–2888

  • Tsai S, Bartelmez S, Sitnicka E, Collins S . 1994 Genes Dev. 8: 2831–2841

  • Tsai S, Collins SJ . 1993 Proc. Natl. Acad. Sci. USA 90: 7153–7157

  • Ueno H, Kizaki M, Matsushita H, Muto A, Yamato K, Nishihara T, Hida T, Yoshimura H, Koeffler HP, Ikeda Y . 1998 Leuk. Res. 22: 517–525

  • van Bockstaele DR, Lenjou M, Snoeck HW, Lardon F, Stryckmans P, Peetermans ME . 1993 Ann. Hematol. 66: 61–66

  • Yamanaka R, Barlow C, Lekstrom-Himes J, Castilla LH, Liu PP, Eckhaus M, Decker T, Wynshaw-Boris A, Xanthopoulos KG . 1997 Proc. Natl. Acad. Sci. USA 94: 13187–13192

  • Zauli G, Visani G, Vitale M, Gibellini D, Bertolaso L, Capitani S . 1995 Br. J. Haematol. 90: 274–282

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Acknowledgements

The work of our laboratory was supported by the Association pour la Recherche sur le Cancer, the Centre National pour la Recherche Scientifique, the Institut National de la Santé et de la Recherche Médicale, the Hôpital Universitaire de Strasbourg, the Collège de France and Bristol-Myers Squibb.

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Correspondence to Susan Chan.

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Kastner, P., Chan, S. Function of RARα during the maturation of neutrophils. Oncogene 20, 7178–7185 (2001). https://doi.org/10.1038/sj.onc.1204757

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